Protein Alignment SoxN and SOX8

DIOPT Version :10

• Sequence 1: NP_001260269.1
• Gene: SoxN / 44275
• FlyBaseID: FBgn0029123
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: NP_055402.2
• Gene: SOX8 / 30812
• HGNCID: 11203
• Length: 446
• Species: Homo sapiens
• Alignment Length: 472
• Identity: 124/472 - (26%)
• Similarity: 172/472 - (36%)
• Gaps: 140/472 - (29%)

  Fly    68 AASQSPNPLSSLQSSMANTLNGSQVGQQQQQQQQQQSSPLHSSSE-LSPTQSSIG--------SH 123
            |.||.|...|...|||::.           :.....:.|..:.|| |.....::|        :.
Human     7 ARSQPPCSPSGTASSMSHV-----------EDSDSDAPPSPAGSEGLGRAGVAVGGARGDPAEAA 60

  Fly   124 HMTSPVSHQQHTQQQQHGQQQHL-------GAGSALSSLTGGSSNNNNNSATANKNQQHADRVKR 181
            ....|...:....|...|....|       |.|.||                  |.:.|   |||
Human    61 DERFPACIRDAVSQVLKGYDWSLVPMPVRGGGGGAL------------------KAKPH---VKR 104

  Fly   182 PMNAFMVWSRGQRRKMASDNPKMHNSEISKRLGAQWKDLSESEKRPFIDEAKRLRAVHMKEHPDY 246
            ||||||||::..|||:|...|.:||:|:||.||..|:.|||||||||::||:|||..|.|:||||
Human   105 PMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLSESEKRPFVEEAERLRVQHKKDHPDY 169

  Fly   247 KYRPRRKTKTLTKTKEK--------YPMGGLM----------------PGQTVGGGAPGEPVTPT 287
            ||:|||:........:.        :|.||.:                .|||  .|.|..|.||.
Human   170 KYQPRRRKSAKAGHSDSDSGAELGPHPGGGAVYKAEAGLGDGHHHGDHTGQT--HGPPTPPTTPK 232

  Fly   288 RVQGQPGQNQSLNGSGGSAAAAA----------AAAAAAAQQARQDMYQMNAPNGYMPNGYMMHA 342
            ....|.|....|...|.....:.          .:..::......|.:.::..:.|:|.|.....
Human   233 TELQQAGAKPELKLEGRRPVDSGRQNIDFSNVDISELSSEVMGTMDAFDVHEFDQYLPLGGPAPP 297

  Fly   343 DPAGAAAYQTSYMGQHYAAQRYDMG--HMYNNGYAMYQTVSGGQTSP--------------YGSS 391
            :|           ||.|....:..|  .::.:..|...:.|..:|.|              ||.
Human   298 EP-----------GQAYGGAYFHAGASPVWAHKSAPSASASPTETGPPRPHIKTEQPSPGHYGD- 350

  Fly   392 LQQPGSPSPYGGSSLQQQ--PGSPT-PYGGGGGGGGQVSCQS------------------HSPSD 435
             |..|||. ||..|.|..  |.:|. |:.|..|..|.:...|                  |||
Human   351 -QPRGSPD-YGSCSGQSSATPAAPAGPFAGSQGDYGDLQASSYYGAYPGYAPGLYQYPCFHSP-- 411

  Fly   436 SSIKSEPVSPSPSAIAL 452
               :....||..:.:||
Human   412 ---RRPYASPLLNGLAL 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SoxN	NP_001260269.1	HMG-box_SoxB	177..252	CDD:438790	47/74 (64%)
SOX8	NP_055402.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..58		13/61 (21%)
		Sox_N	18..89	CDD:463586	12/81 (15%)
		Dimerization (DIM). /evidence=ECO:0000303|PubMed:31194875	58..100		9/59 (15%)
		HMG-box_SoxE	101..175	CDD:438840	48/76 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	155..259		30/105 (29%)
		Transactivation domain (TAM). /evidence=ECO:0000303|PubMed:31194875	224..298		12/73 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	318..378		17/62 (27%)
		Transactivation domain (TAC). /evidence=ECO:0000303|PubMed:31194875	335..446		24/99 (24%)
		9aaTAD. /evidence=ECO:0000269|PubMed:34342803	400..408		0/7 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	425..446		1/1 (100%)