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Protein Alignment sns and NECTIN1

DIOPT Version :10

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_002846.3	Gene:	NECTIN1 / 5818	HGNCID:	9706	Length:	517	Species:	Homo sapiens

Alignment Length:	545	Identity:	109/545 - (20%)
Similarity:	173/545 - (31%)	Gaps:	166/545 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   612 WWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLY 676
            ||  |:.: |:.....||:....       |.|...|.|.:.|                  ||:.
Human    13 WW--GLAL-GLTAFFLPGVHSQV-------VQVNDSMYGFIGT------------------DVVL 49

  Fly   677 RPKFVPPPSSTAV-------GVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRI------ 728
            ...|..|..|..:       ...|....|::.   ||:.        |.::......|:
Human    50 HCSFANPLPSVKITQVTWQKSTNGSKQNVAIY---NPSM--------GVSVLAPYRERVEFLRPS 103

  Fly   729 FADGGSLNFTRLHRDDAGIYSCSASNSQGG---ATLNITVVVEYGTTIKSVSENIVVNPGED--- 787
            |.| |::..:||..:|.|:|.|..:....|   :.||:||:.:....|:.....:....|:|
Human   104 FTD-GTIRLSRLELEDEGVYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKV 167

  Fly   788 AMLSCT-VEGKPLTEEHVKWERVGYDMTVKTSTTF-----ANGT----SYLHIKDAKREDVGNFR 842
            .:.:|| ..|||  ...|.||     ..:|....:     .|||    |...:..::.....:..
Human   168 LVATCTSANGKP--PSVVSWE-----TRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLA 225

  Fly   843 CVADNRVDNPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGR----LPCRAQGS-PKPQFIWRQ 902
            |:.:..:|. ....:.|.|::.||:.     :....|.....|    |.|:|..: |..::.|..
Human   226 CIVNYHMDR-FKESLTLNVQYEPEVT-----IEGFDGNWYLQRMDVKLTCKADANPPATEYHWTT 284

  Fly   903 DKKDLP-----INRTYKYEVEERKIDSLTYESTLIVDKVAPADY---GAYECVARNELGEAVETV 959
            ....||     .|||..::                    .|.:|   |.|.|.|.|.:|.....|
Human   285 LNGSLPKGVEAQNRTLFFK--------------------GPINYSLAGTYICEATNPIGTRSGQV 329

  Fly   960 RLEITS---QPDP--------PLSLNILNVTHDTVTLAWTPGFDGGLKASYRVRYR--MADREQY 1011
            .:.||.   .|.|        |:...|:.....::.|...  ..||:..:.|.|..  ..|....
Human   330 EVNITEFPYTPSPPEHGRRAGPVPTAIIGGVAGSILLVLI--VVGGIVVALRRRRHTFKGDYSTK 392

  Fly  1012 KYI-------DGLPNSHKLTIGGLRMNTLYLFSVMSWNELGQSSYLPDLARAETKEAPPPSHPAS 1069
            |::       .|:|..|.                    .:.|:...||.:..|.|..|
Human   393 KHVYGNGYSKAGIPQHHP--------------------PMAQNLQYPDDSDDEKKAGP------- 430

  Fly  1070 SLGGGP-PTTSQTPLGGTSGMLLVG 1093
             |||.. ....:...||..|...||
Human   431 -LGGSSYEEEEEEEEGGGGGERKVG 454

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.