Protein Alignment wit and TGFBR1

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_001293139.1
• Gene: TGFBR1 / 7046
• HGNCID: 11772
• Length: 507
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 145/496 - (29%)
• Similarity: 219/496 - (44%)
• Gaps: 96/496 - (19%)

  Fly    94 CWKDN----TDRTSICSQSECTSS----------------------APTSKTSSL---YYCCCSG 129
            |.|||    ||.....|.:|.|..                      ||:|||.|:   |  ||:.
Human    41 CTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTY--CCNQ 103

  Fly   130 GVCNAQYSVVEPAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGIFLAVQYC- 193
            ..|| :..:....|..:.|:.|...:...|.              :||.:..:.|.:.|.|..|
Human   104 DHCN-KIELPTTGPFSVKSSPGLGPVELAAV--------------IAGPVCFVCISLMLMVYICH 153

  Fly   194 -RTAKEKPEP-EESP-------------------LAPSGPGYSSNL---RNV-DNMNLIGMLGSG 233
             ||......| ||.|                   :..||.|....|   |.: ..:.|...:|.|
Human   154 NRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKG 218

  Fly   234 KYGTVMKGLLHDQEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRMEYQ- 297
            ::|.|.:|....:||||||:.....:.:..|..||...::....:|.:...|.:   |.....|
Human   219 RFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNK---DNGTWTQL 280

  Fly   298 -LVLSLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRNVL 361
             ||......|.|.|:|...|:|......:..|...|::|||.|: :|.|.||.:||||:.::|:|
Human   281 WLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEI-VGTQGKPAIAHRDLKSKNIL 344

  Fly   362 VQADLSCCIADFGFALKVFGSKYEYKGEVAMAETKSI---NEVGTLRYMAPELLEGAVNLRDCET 423
            |:.:.:|||||.|.|::          ..:..:|..|   :.|||.||||||:|:.::|::..|
Human   345 VKKNGTCCIADLGLAVR----------HDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFE- 398

  Fly   424 SLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFP 488
            |.|:.|:||:|||.||:|.|||    .|.....|:.||...|.|.||.::|:.:|...|.||..|
Human   399 SFKRADIYAMGLVFWEIARRCS----IGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIP 459

  Fly   489 TGWGGGAAAKVVRDTCEDCWDHDADARLTSLCAEERMQEMS 529
            ..|....|.:|:.....:||..:..||||:|..::.:.::|
Human   460 NRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLS 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	20/72 (28%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	102/304 (34%)
TGFBR1	NP_001293139.1	TFP_LU_ECD_ALK5	35..108	CDD:467067	20/69 (29%)
		TGF_beta_GS	180..207	CDD:462503	5/26 (19%)
		STKc_TGFbR1_ACVR1b_ACVR1c	213..500	CDD:271045	102/305 (33%)