Protein Alignment wit and BMPR2

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_001195.2
• Gene: BMPR2 / 659
• HGNCID: 1078
• Length: 1038
• Species: Homo sapiens
• Alignment Length: 1049
• Identity: 291/1049 - (27%)
• Similarity: 446/1049 - (42%)
• Gaps: 263/1049 - (25%)

  Fly     3 WAIYLLLALISLGRATPVPNRQYSCM---SYQEDDNSFHDDDGDQDSSGELQEQQVESTPIPSEP 64
            |..:.:| |:|...|:  .|::..|.   .||:|                   ..:..:.|..|.
Human    13 WLPWTIL-LVSTAAAS--QNQERLCAFKDPYQQD-------------------LGIGESRISHEN 55

  Fly    65 HRRTCPDGYTFCFTIWNQTANGARVVKQGCWKDNTDRTSICSQSEC--TSSAPTSKTSSLYYCCC 127
            ....|..|.| |:.:|.::.....:||||||....|... |...||  |::.|:.:..:..:|||
Human    56 GTILCSKGST-CYGLWEKSKGDINLVKQGCWSHIGDPQE-CHYEECVVTTTPPSIQNGTYRFCCC 118

  Fly   128 SGGVCNAQYSVVEPAPLEL------GSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALT--- 183
            |..:||..::...|.|...      ..|...|.|...|:    .|.||..::.|..|...||
Human   119 STDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALAS----VSVLAVLIVALCFGYRMLTGDR 179

  Fly   184 -IGIFLAVQYCRTAKEKPEPEESPLAPSGPGYSSNLRNVDNMNLIGMLGSGKYGTVMKGLLHDQE 247
             .|:. ::.....|..:|.                 .::||:.|:.::|.|:||.|.||.|.::.
Human   180 KQGLH-SMNMMEAAASEPS-----------------LDLDNLKLLELIGRGRYGAVYKGSLDERP 226

  Fly   248 VAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRMEYQLVLSLAPLGCLQDWL 312
            ||||::...:.|.::||:|||.:||||...:..:...|||.|.||||||.||:...|.|.|..:|
Human   227 VAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYL 291

  Fly   313 IANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRNVLVQADLSCCIADFGFAL 377
            ..:|..:...|.:..|:|||:::|||||..||.:||.::|||:|:|||||:.|.:|.|:|||.::
Human   292 SLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSM 356

  Fly   378 KVFGSKYEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNLRDCETSLKQMDVYALGLVLWEVAT 442
            ::.|::....||   .:..:|:||||:||||||:|||||||||||::|||:|:|||||:.||:..
Human   357 RLTGNRLVRPGE---EDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFM 418

  Fly   443 RCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGW-GGGAAAKVVRDTCED 506
            ||:|.: ||::.|.|:..::.|||:||:|:.||.||.|.|.||.||..| ....|.:.:::|.||
Human   419 RCTDLF-PGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIED 482

  Fly   507 CWDHDADARLTSLCAEERMQEM-----------STLRPRAQAQPSSPLLNTNNLV---------- 550
            |||.||:||||:.||||||.|:           .|:.|.:.|..:...|:.|..|
Human   483 CWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYS 547

  Fly   551 ASPTAEQGINIIATTTTAAAVHHQMSSDTTGLIQPPPNQQIPLAALEREKNHLSYPQQQLQ---- 611
            :|...|..|:...:.....:..|.|||             .||...|:.:|.::|.:||.|
Human   548 SSSYIEDSIHHTDSIVKNISSEHSMSS-------------TPLTIGEKNRNSINYERQQAQARIP 599

  Fly   612 ---------------------------------PYQGRNPCQERNLAPLTMRTP----------- 632
                                             ||.........|:|.....||
Human   600 SPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDETNLHTTNVAQSIGPTPVCLQLTEEDLE 664

  Fly   633 -----PVLVERSKKHSFQTQPQENSLSCLEHDVSVEELIASHQHQQQKNTIVSTG-------GNG 685
                 |..|:::.|.|......|:||........:....:|..:...|..:.:||       .||
Human   665 TNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEATGQQDFTQTANG 729

  Fly   686 NSCLGQG--------FPKQQN-----TDQKLRGWHGVRALIHKKLFRKEHAEELCRQLQLGEEKS 737
            .:||...        .|||||     |...|...:..:.  .:..|..:|...| :|::.|..|.
Human   730 QACLIPDVLPTQIYPLPKQQNLPKRPTSLPLNTKNSTKE--PRLKFGSKHKSNL-KQVETGVAKM 791

  Fly   738 NLVTA-------------------------------------------------------LRRPN 747
            |.:.|                                                       :....
Human   792 NTINAAEPHVVTVTMNGVAGRNHSVNSHAATTQYANGTVLSGQTTNIVTHRAQEMLQNQFIGEDT 856

  Fly   748 NLDLNPRLDKPPPDQLRSAEQRMGTPAHIVPRSLSSSLIKHINGTTNNNSIQSHG-SELQTL--- 808
            .|::|...|:..|  |...||:.|....::.|.:.........|.||:|:..|:. ||...|
Human   857 RLNINSSPDEHEP--LLRREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQDVLAQG 919

  Fly   809 ----------TRPASKRRPGHLRTNSLMATTGQGPPTEQQMRRQHSLEVFREVFSGR-GSSERLR 862
                      ::|...:||..|..::.....|.            |:::......|: ||.|:::
Human   920 VPSTAADPGPSKPRRAQRPNSLDLSATNVLDGS------------SIQIGESTQDGKSGSGEKIK 972

  Fly   863 DPSERVKTP 871
               :|||||
Human   973 ---KRVKTP 978

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	29/117 (25%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	147/300 (49%)
BMPR2	NP_001195.2	TFP_LU_ECD_BMPR2	32..131	CDD:467134	29/119 (24%)
		STKc_BMPR2_AMHR2	207..504	CDD:270956	147/300 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	593..626		2/32 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	746..770		7/25 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	872..972		22/111 (20%)