Protein Alignment wit and ACVR1C

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_660302.2
• Gene: ACVR1C / 130399
• HGNCID: 18123
• Length: 493
• Species: Homo sapiens
• Alignment Length: 499
• Identity: 138/499 - (27%)
• Similarity: 214/499 - (42%)
• Gaps: 87/499 - (17%)

  Fly    76 CFTIWNQTANGARVVKQGCW--------KDNTDRTSIC-----SQSECTSSAPTSKTSSLYYCCC 127
            |..:...::|.....:..||        |:...::.:.     :|..|.||...:||.     ||
Human    28 CVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTE-----CC 87

  Fly   128 SGGVCN---AQYSVVEPAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGIFLA 189
            ....||   .......|...:||..|....||           :...:|.:|..||.      .|
Human    88 FTDFCNNITLHLPTASPNAPKLGPMELAIIIT-----------VPVCLLSIAAMLTV------WA 135

  Fly   190 VQ--YCRTAKEKPEPEESPLAP---------------------SGPGYSSNLRNVDNMNLI--GM 229
            .|  .|...|:|....|.||:.                     ||.|....::......::  .:
Human   136 CQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEI 200

  Fly   230 LGSGKYGTVMKGLLHDQEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRM 294
            :|.|::|.|..|....::|||||:.....:.:..|..||...::....:|.:...|.:   |...
Human   201 VGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNK---DNGT 262

  Fly   295 EYQ--LVLSLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINT 357
            ..|  ||......|.|.|:|..|.:|.:....:..||..|::|||.|: :|.|.||.:|||||.:
Human   263 WTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEI-VGTQGKPAIAHRDIKS 326

  Fly   358 RNVLVQADLSCCIADFGFALKVFGSKYEYKGEVAMAETKSINE---VGTLRYMAPELLEGAVNLR 419
            :|:||:...:|.|||.|.|:|          ..::..|..|.:   |||.||||||:|:..:|:.
Human   327 KNILVKKCETCAIADLGLAVK----------HDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVN 381

  Fly   420 DCETSLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKAR 484
            ..| |.|:.|:|::|||.||:|.|||    .|.....|:.||...|.|.||.::|:.:|...|.|
Human   382 IFE-SFKRADIYSVGLVYWEIARRCS----VGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFR 441

  Fly   485 PLFPTGWGGGAAAKVVRDTCEDCWDHDADARLTSLCAEERMQEM 528
            |..|..|....|.:|:.....:||..:..||||:|..::.:.::
Human   442 PSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	15/77 (19%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	102/304 (34%)
ACVR1C	NP_660302.2	TFP_LU_ECD_ALK7	24..99	CDD:467070	15/75 (20%)
		TGF_beta_GS	166..193	CDD:462503	3/26 (12%)
		STKc_TGFbR1_ACVR1b_ACVR1c	199..486	CDD:271045	102/306 (33%)