Protein Alignment wit and Acvr1b

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_031421.1
• Gene: Acvr1b / 11479
• MGIID: 1338944
• Length: 505
• Species: Mus musculus
• Alignment Length: 451
• Identity: 129/451 - (28%)
• Similarity: 198/451 - (43%)
• Gaps: 78/451 - (17%)

  Fly   123 YYC----------CCSGGVCNAQYSVVEPAPLELGSNEGRTSITNRATEKQHQSFLAST-MLGLA 176
            :||          ||....||         .::|....|...      |..|.|..... ::|:.
Mouse    82 FYCLSSEDLRNTHCCYIDFCN---------KIDLRVPSGHLK------EPAHPSMWGPVELVGII 131

  Fly   177 GG----LTALTIGIFLAVQY-----------------CRTAKEKPEPEES---PLAPSGPGYSSN 217
            .|    |..:.|.:||.:.|                 |.....|.:..:.   .|:.||.|....
Mouse   132 AGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLP 196

  Fly   218 L---RNV-DNMNLIGMLGSGKYGTVMKGLLHDQEVAVKIYPEEHHQYYVNERNIYALPLMECPAL 278
            |   |.| ..:.|..::|.|::|.|.:|.....:|||||:.....:.:..|..||...::....:
Mouse   197 LFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENI 261

  Fly   279 LSYFGYDERCTMDGRMEYQ--LVLSLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELR 341
            |.:...|.:   |.....|  ||......|.|.|:|...|:|......:..|...|::|||.|:
Mouse   262 LGFIAADNK---DNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEI- 322

  Fly   342 LGDQHKPCVAHRDINTRNVLVQADLSCCIADFGFALKVFGSKYEYKGEVAMAETKSI---NEVGT 403
            :|.|.||.:||||:.::|:||:.:..|.|||.|.|::          ..|:.:|..|   ..|||
Mouse   323 VGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVR----------HDAVTDTIDIAPNQRVGT 377

  Fly   404 LRYMAPELLEGAVNLRDCETSLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSH 468
            .||||||:|:..:|::..: |.|..|:||||||.||:|.||:.    |.....|:.||...|.|.
Mouse   378 KRYMAPEVLDETINMKHFD-SFKCADIYALGLVYWEIARRCNS----GGVHEDYQLPYYDLVPSD 437

  Fly   469 PSFDQMQALVVRHKARPLFPTGWGGGAAAKVVRDTCEDCWDHDADARLTSLCAEERMQEMS 529
            ||.::|:.:|...|.||..|..|....|.:|:.....:||..:..||||:|..::.:.::|
Mouse   438 PSIEEMRKVVCDQKLRPNVPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLS 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	6/24 (25%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	100/304 (33%)
Acvr1b	NP_031421.1	TFP_LU_ECD_ALK4	30..102	CDD:467066	4/19 (21%)
		GS	177..207	CDD:197743	7/29 (24%)
		STKc_TGFbR1_ACVR1b_ACVR1c	211..498	CDD:271045	100/305 (33%)