Protein Alignment wit and acvr2a

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_017952544.1
• Gene: acvr2a / 100216172
• XenbaseID: XB-GENE-484012
• Length: 521
• Species: Xenopus tropicalis
• Alignment Length: 516
• Identity: 167/516 - (32%)
• Similarity: 262/516 - (50%)
• Gaps: 77/516 - (14%)

  Fly    67 RTCPDGYTF----------CFTIWNQTANGARVVKQGCWKDNTDRTSIC-SQSECTSSAPTSKTS 120
            :|.|:|...          ||..|...:....:||||||.|:.:    | .:|:||.   ..::.
 Frog    41 KTNPNGTEICYGDNDKRRHCFATWKNISGSIEIVKQGCWLDDMN----CYDKSDCTE---RKESP 98

  Fly   121 SLYYCCCSGGVCNAQY------SVVEPAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGL 179
            .:::|||.|..||.::      .|.:|.     ||...|           :..|.:|:|.....:
 Frog    99 DVFFCCCEGNTCNERFYHSPEMEVTQPT-----SNPVPT-----------KPPLFNTLLYSLVPI 147

  Fly   180 TALTIGIFLAVQYCRTAKEKPEPEESP--------LAPSGPGYSSNLRNVDNMNLIGMLGSGKYG 236
            ..:.:.:..:....|..|....|...|        :...||...|.|..:..:.|:.:...|::|
 Frog   148 MVVAVIVLFSFWMYRHHKLAYPPVLVPTQHAFHIMIEDPGPPPPSPLLGLKPLQLLEVKARGRFG 212

  Fly   237 TVMKGLLHDQEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCT-MDGRMEYQLVL 300
            .|.|..|.::.|||||:|.:....:.||..||.||.|:...:|.:.|.::|.| :|  .:..|:.
 Frog   213 CVWKAQLLNETVAVKIFPIQDKLSWQNEYEIYNLPGMKHENILQFIGAEKRGTNLD--TDLWLIT 275

  Fly   301 SLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTEL-RLGDQHKPCVAHRDINTRNVLVQA 364
            :....|.|.|:|.||.::::|.|.:..::.||:::||.:: .|.|.|||.||||||.::|:|::.
 Frog   276 AFHEKGSLTDYLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAVAHRDIKSKNILLKN 340

  Fly   365 DLSCCIADFGFALKVFGSKYEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNL-RDCETSLKQM 428
            .|:.||||||.|||.         |...:...:..:|||.||||||:||||:|. ||   :..::
 Frog   341 SLTACIADFGLALKF---------EAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRD---AFLRI 393

  Fly   429 DVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGWGG 493
            |:||.||||||:|:||:....|   ...|..|:|:|||.|||.:.||.:||..|.||:....|..
 Frog   394 DMYAFGLVLWELASRCTASDGP---VDEYMLPFEEEVGQHPSLEDMQEVVVHKKKRPILRECWQK 455

  Fly   494 GAAAKVVRDTCEDCWDHDADARLTSLCAEERMQEMSTLRPRAQAQPSSPLLNTNNLVASPT 554
            .|...::.:|.|:||||||:|||::.|.|||:.:|..|         :.::.|.::|...|
 Frog   456 HAGMAMLCETIEECWDHDAEARLSAGCVEERIIQMQKL---------TNIITTEDIVTVVT 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	23/87 (26%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	122/302 (40%)
acvr2a	XP_017952544.1	TFP_LU_ECD_ACVR2A	25..119	CDD:467151	23/84 (27%)
		STKc_ACVR2a	204..493	CDD:271043	123/305 (40%)