Protein Alignment Rs1 and DRS1

DIOPT Version :10

• Sequence 1: NP_651970.1
• Gene: Rs1 / 44087
• FlyBaseID: FBgn0021995
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_013093.1
• Gene: DRS1 / 850652
• SGDID: S000003931
• Length: 752
• Species: Saccharomyces cerevisiae
• Alignment Length: 782
• Identity: 286/782 - (36%)
• Similarity: 440/782 - (56%)
• Gaps: 128/782 - (16%)

  Fly     1 MGATK--NLDLIGTI---EDDAEVENLSEDSDAEVEYQPTKLR-----HKKVTE----------- 44
            :|..|  |||.:.||   |||..:.:.|:|...|.: :.||.|     .|||:|
Yeast     3 VGTKKYSNLDFVPTISDSEDDVPILDSSDDEKVEAK-KTTKKRKGKNNKKKVSEGDNLDEDVHED 66

  Fly    45 FEKGFEF-------VSSVKEYN-----QDTWDDLMKYVKRKARTKTDDKIAARLQKRGGAEAVA- 96
            .:.||:|       .|:.:.:|     :...||...:||:....   |||   ::::||...:|
Yeast    67 LDAGFKFDLDADDTTSNFQGWNFLAEGESNKDDAEAFVKKDVDL---DKI---IRRKGGLVKMAH 125

  Fly    97 -----AEQSDGSEI----DLSEDELKHDNLRL---------REKKESKKKKKKAGEEDEEDEGEK 143
                 .|:::..::    |..::||..|...:         .:.:|.:::::|..||:||:|.|:
Yeast   126 IDSKQEEETEKEKVEKENDSDDEELAMDGFGMGAPMNNGDENQSEEEEEEEEKEEEEEEEEEQEE 190

  Fly   144 MQ-----------------------FADTVEANEQITSFYQ----MNLSRPLMRAIGVLGYIYPT 181
            |.                       :|...|.:|.....|:    ::||||:::.:..|||:.|:
Yeast   191 MTLEKGGKDDEIDEEDDSEEAKADFYAPETEGDEAKKQMYENFNSLSLSRPVLKGLASLGYVKPS 255

  Fly   182 PIQASTIPVALLGRDICGCAATGTGKTAAYMLPTLERLLYRPLNNKAITRVLVLVPTRELGAQVY 246
            |||::|||:||||:||...|.||:|||||:|:|.:|||||:|. ..|.|||:||:|||||..||.
Yeast   256 PIQSATIPIALLGKDIIAGAVTGSGKTAAFMIPIIERLLYKPA-KIASTRVIVLLPTRELAIQVA 319

  Fly   247 QVTKQLCQFTT-IDVGLAIGGLDVKAQEAVLRQNPDIVIATPGRLIDHIKNTPSFTLDSIEVLIL 310
            .|.||:.:|.: |..|||:|||:::.||.:|:..||||||||||.||||:|:.||.:||:|:|::
Yeast   320 DVGKQIARFVSGITFGLAVGGLNLRQQEQMLKSRPDIVIATPGRFIDHIRNSASFNVDSVEILVM 384

  Fly   311 DEADRMLDEYFAEQMKEIINSCCKTRQTMLFSATMSEQVKDLAAVSLDKPIKVFVNNNQQVAFNL 375
            |||||||:|.|.:::.||:......||.:||||||:.::|.|.::||.||:::.::..::.|..|
Yeast   385 DEADRMLEEGFQDELNEIMGLLPSNRQNLLFSATMNSKIKSLVSLSLKKPVRIMIDPPKKAATKL 449

  Fly   376 RQEFIRIREDKEGDREPILASLICR---TFHDHCMVFVQTKKQAHRLHILLGLLGVRAGELHGNL 437
            .|||:|||: ::..:..:|.:||.:   |.....:|||..|:.||||.|::||||:..|||||:|
Yeast   450 TQEFVRIRK-RDHLKPALLFNLIRKLDPTGQKRIVVFVARKETAHRLRIIMGLLGMSVGELHGSL 513

  Fly   438 TQQQRLESLKKFKEEQIDVLIATDVAARGLDIVGVKTVINFVMPITTEHYIHRVGRTARAGRAGI 502
            ||:|||:|:.|||..::.|||.||:|:|||||..::.|||:.||.:.|.|:|||||||||||.|.
Yeast   514 TQEQRLDSVNKFKNLEVPVLICTDLASRGLDIPKIEVVINYDMPKSYEIYLHRVGRTARAGREGR 578

  Fly   503 SVSLAGE--KERKIVKDIIKNAE---STIKNRIIPPEI----IEKYRNKLTSLEPEIQNILDEEQ 558
            ||:..||  ::|.||:..||:.|   |..:.:.:...:    ||:....:.|:...|::||.||:
Yeast   579 SVTFVGESSQDRSIVRAAIKSVEENKSLTQGKALGRNVDWVQIEETNKLVESMNDTIEDILVEEK 643

  Fly   559 AERQLAKTEQQLSKTERKLLG----QTNERRGWFQTKQQREAEKDRLALTTGDEDKASGGKGKGK 619
            .|:::.:.|.||.|.|..|..    |...||.|||::..::..|...||:.  ..|.:..|
Yeast   644 EEKEILRAEMQLRKGENMLKHKKEIQARPRRTWFQSESDKKNSKVLGALSR--NKKVTNSK---- 702

  Fly   620 TAGKRKRPEYGGDGEDGPPVKDLEAKRNKKKKEEPRKKTPEQLAKERAMKEIEKVSLVRAKMAKL 684
               ||||.|...||         ...|:.:|     .||.....:||..|:.:..:..:.|..|.
Yeast   703 ---KRKREEAKADG---------NGARSYRK-----TKTDRIADQERTFKKQKSTNSNKKKGFKS 750

  Fly   685 RK 686
            |:
Yeast   751 RR 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rs1	NP_651970.1	SrmB	156..576	CDD:440279	205/436 (47%)
DRS1	NP_013093.1	SrmB	232..674	CDD:440279	206/443 (47%)