Protein Alignment Rs1 and ddx18

DIOPT Version :10

• Sequence 1: NP_651970.1
• Gene: Rs1 / 44087
• FlyBaseID: FBgn0021995
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_001003411.1
• Gene: ddx18 / 321127
• ZFINID: ZDB-GENE-030131-9685
• Length: 653
• Species: Danio rerio
• Alignment Length: 573
• Identity: 169/573 - (29%)
• Similarity: 296/573 - (51%)
• Gaps: 51/573 - (8%)

  Fly    14 EDDAEVENLSEDSDAEVEYQPTKLRHKKVTEFEKGFEFVSSVKEYNQDTWDDLMKYVKRKARTKT 78
            |:..||:::.::|:...:..|                  :.::|..|...|::.:..::..:.|.
Zfish    33 ENSEEVKDVLDESEVASDSAP------------------NVIEEQQQSVSDEVNETSQKPKKKKK 79

  Fly    79 DDKIAARLQKRGGAEAVAAEQS-DGSEIDLSEDELKHD-NLR-LREKKESKKKKKKAGEEDEEDE 140
            ..|:.|..:....:...|.:|| |.::....|:|.:.: ||. ::..:....:|:.:.|||.:::
Zfish    80 KRKLDATGESTTSSVKKAKKQSVDTTQASAGEEEQQEEGNLETVKCPENGNNEKEGSAEEDSDED 144

  Fly   141 GEKMQFADTVEANEQITSFYQMN--LSRPLMRAIGVLGYIYPTPIQASTIPVALLGRDICGCAAT 203
            |.::....|....::  ||..::  :|...::.:..:|:...|.||..||...|.|||:...|.|
Zfish   145 GPQLPSGLTGAFEDR--SFASLSEVVSENTLKGVKEMGFDTMTEIQHKTIRPLLEGRDVLAAAKT 207

  Fly   204 GTGKTAAYMLPTLE---RLLYRPLNNKAITRVLVLVPTRELGAQVYQVTKQLCQFTTIDVGLAIG 265
            |:|||.|:::|::|   :|.:.|.|.   |.|:||.|||||..|.|.|.|:|........||.:|
Zfish   208 GSGKTLAFLIPSIELIYKLKFMPRNG---TGVIVLSPTRELAMQTYGVLKELMTHHVHTYGLIMG 269

  Fly   266 GLDVKAQEAVLRQNPDIVIATPGRLIDHIKNTPSFTLDSIEVLILDEADRMLDEYFAEQMKEIIN 330
            |.:..|:...|....:|::||||||:||::|||.|...:::.||:|||||:|:..|.|::|:||.
Zfish   270 GSNRSAEAQKLANGVNILVATPGRLLDHLQNTPGFMFKNLQCLIIDEADRILEVGFEEELKQIIK 334

  Fly   331 SCCKTRQTMLFSATMSEQVKDLAAVSLDK-PIKVFVNNNQQVAF--NLRQEFIRIREDKEGDREP 392
            ...|.||:||||||.:.:|:|||.:||.| |:.|.|::|:..|.  .|.|.::....:|   |..
Zfish   335 LLPKKRQSMLFSATQTRKVEDLARISLKKEPLYVGVDDNKDTATVEGLEQGYVVCPSEK---RFL 396

  Fly   393 ILASLICRTFHDHCMVFVQTKKQAHRLHILLGLLGVRAGELHGNLTQQQRLESLKKFKEEQIDVL 457
            :|.:.:.:......|||..:.......:.||..:.:....:||...|.:|..:..:|......:|
Zfish   397 LLFTFLKKNRKKKLMVFFSSCMSVKFHYELLNYIDLPVMAIHGKQKQTKRTTTFFQFCNADSGIL 461

  Fly   458 IATDVAARGLDIVGVKTVINFVMPITTEHYIHRVGRTARA--GRAGISVSLAGEKERKIVKDIIK 520
            :.||||||||||..|..::.|..|...:.||||||||||.  || |.::.:...:|...:: .:|
Zfish   462 LCTDVAARGLDIPEVDWIVQFDPPDDPKEYIHRVGRTARGINGR-GHALLILRPEELGFLR-FLK 524

  Fly   521 NAESTIKNRIIPPEIIEKYRNKLTSLEPEIQNILDEEQAERQLAKTEQQLSKT 573
            .|:       :|....|....|::.::.::..::::..   .|.|:.|:..|:
Zfish   525 QAK-------VPLSEFEFSWTKISDIQSQLDKLIEKNY---YLHKSAQEAYKS 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rs1	NP_651970.1	SrmB	156..576	CDD:440279	144/428 (34%)
ddx18	NP_001003411.1	DEADc_DDX18	172..369	CDD:350700	85/199 (43%)
		SF2_C_DEAD	382..512	CDD:350174	42/133 (32%)
		DUF4217	544..601	CDD:464056	4/27 (15%)