Protein Alignment Rs1 and Ddx10

DIOPT Version :10

• Sequence 1: NP_651970.1
• Gene: Rs1 / 44087
• FlyBaseID: FBgn0021995
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_001100290.1
• Gene: Ddx10 / 300710
• RGDID: 1308990
• Length: 874
• Species: Rattus norvegicus
• Alignment Length: 772
• Identity: 218/772 - (28%)
• Similarity: 351/772 - (45%)
• Gaps: 123/772 - (15%)

  Fly   113 KHDNLRLREKKESKKKKKKAGEEDEEDEG--EKMQFADTVEANEQITSFYQMNLSRPLMRAIGVL 175
            ||.: |..:|||.:|:.||. |...|.||  ..||..:.:..|| ||.|....||:..::.:...
  Rat    26 KHSH-RQHQKKERRKQLKKP-EWQVEREGISRLMQNYEKINVNE-ITRFSDFPLSKKTLKGLQEA 87

  Fly   176 GYIYPTPIQASTIPVALLGRDICGCAATGTGKTAAYMLPTLERLLYRPLNNKAITRVLVLVPTRE 240
            .|...|.||..||.:||.|:|:.|.|.||:|||.|:::|.||.|......:.....||::.||||
  Rat    88 QYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRE 152

  Fly   241 LGAQVYQVTKQLCQFTTIDVGLAIGGLDVKAQEAVLRQNPDIVIATPGRLIDHIKNTPSFTLDSI 305
            |..|.::|.:::.:......||.|||.|:| .||....|.:|::.|||||:.|:..|..|...::
  Rat   153 LAYQTFEVLRKVGKNHDFSAGLIIGGKDLK-HEAERINNINILVCTPGRLLQHMDETICFHATNL 216

  Fly   306 EVLILDEADRMLDEYFAEQMKEIINSCCKTRQTMLFSATMSEQVKDLAAVSLDKPIKVFVNNNQQ 370
            ::|:||||||:||..||:.|..||.:..|.|||:|||||.::.|||||.:||..|..|:|:...:
  Rat   217 QMLVLDEADRILDMGFADTMNAIIENLPKKRQTLLFSATQTKSVKDLARLSLKDPEYVWVHEKAK 281

  Fly   371 VA--FNLRQEFIRIREDKEGDREPILASLICRTFHDHCMVFVQTKKQAHRLHILLGLL--GVRAG 431
            .:  ..|.|.:| |.|..:  :..:|.|.:........:||..:.|:...|:.:...|  |:...
  Rat   282 YSTPATLEQNYI-ICELHQ--KISVLFSFLRSHLTKKSIVFFSSCKEVQYLYRVFCRLRPGISIL 343

  Fly   432 ELHGNLTQQQRLESLKKFKEEQIDVLIATDVAARGLDIVGVKTVINFVMPITTEHYIHRVGRTAR 496
            .|||...|.:|:|...:|..::..||.|||:||||||...|..|:.|..|.....||||.|||||
  Rat   344 ALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLDFPAVNWVLQFDCPEDANTYIHRAGRTAR 408

  Fly   497 AGRAGIS-VSLAGEKERKIVKDIIKNAESTIKNRIIPPEIIEKYRNKLTSLEPEIQNILDEEQAE 560
            ....|.: :.|...:|:.:|:.:::. :..:|...|.||.:...:.:|.|...:.|::  :|:|:
  Rat   409 YKEDGEALLILLPSEEQGMVQQLLQK-KVPVKEIKINPEKLIDVQKRLESFLAQDQDL--KERAQ 470

  Fly   561 R---------------------QLAKTE----------------QQLSKTERKLLG--------- 579
            |                     :|..||                |::.|...|.||
  Rat   471 RCFVSYIRSVYLMKDKEVFDVNKLPITEYALSLGLAVAPRIRFLQKMEKQPNKELGKNQVTEAIQ 535

  Fly   580 ---------QTNERRGWFQTKQQ------REAEKDRLALTTG---DEDKASGGKGKGKTAGKRKR 626
                     :..|.|.:|..|..      :..|:...:|.:|   ::|:.:..:......|:.:.
  Rat   536 PRAPSLTSDEVEEFRAYFSEKMSILHKSGKRLEETEHSLASGESEEQDEETEDEEMEDHVGQTRE 600

  Fly   627 P----------------------EYGGDGEDGPPVKDLEAKR------NKKKKEEPRKKTPEQLA 663
            |                      :...|.||||....|..||      :.|:.|...||.|   :
  Rat   601 PPTDSVPRSEEAQKVKEVPVQFLDRDDDEEDGPDADFLTVKRRDVFGLDLKENEALSKKEP---S 662

  Fly   664 KERAMKEIEKVSLVRAKMAKLRKRPGKLGAATEVHRSGASDGKPKRRGG--QSAFTNDLTDVSRG 726
            |....|::.||    |:..|:.||..|:....    :...:|:..::..  |...|||:.:....
  Rat   663 KSSVKKKLTKV----AEAKKVMKRNFKVNKKI----TFTDEGELVQQWPQIQKCATNDVEEEDDT 719

  Fly   727 GALRLRSEANRHKKMTKIAAKKKASSVKLTNKAGKNKFNKGKNFGGPRHAK-KDKKK 782
            |.:.|.....|.::..|...::....:|..::..:.|..:.:.....|.|| :|:::
  Rat   720 GGINLDKAKERLQEEDKFDKEEYRKKIKAKHRERRLKEREARREANKRQAKARDEEE 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rs1	NP_651970.1	SrmB	156..576	CDD:440279	151/461 (33%)
Ddx10	NP_001100290.1	SrmB	68..470	CDD:440279	144/408 (35%)
		DEADc_DDX10	80..277	CDD:350699	82/197 (42%)
		DUF4217	452..510	CDD:464056	9/59 (15%)
		PTZ00121	<608..>827	CDD:173412	37/180 (21%)
		PLN02316	<727..>775	CDD:215180	8/47 (17%)