Protein Alignment msn and Nrk

DIOPT Version :10

• Sequence 1: NP_524679.3
• Gene: msn / 44030
• FlyBaseID: FBgn0010909
• Length: 1504
• Species: Drosophila melanogaster
• Sequence 2: XP_006528613.1
• Gene: Nrk / 27206
• MGIID: 1351326
• Length: 1512
• Species: Mus musculus
• Alignment Length: 1690
• Identity: 475/1690 - (28%)
• Similarity: 722/1690 - (42%)
• Gaps: 413/1690 - (24%)

  Fly    21 DLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTE------------------ 67
            ||..|.||.|||.|.:.:|.||||:::.|.|.|||.|.|:|||...:
Mouse    14 DLGQLPDPTGIFSLDKAIGLGTYGRIFLGIHEKTGSLVAVKVMSARKTPLPEIGRRVRVNKYQKS 78

  Fly    68 ------DEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKS 126
                  ||||:::.|:|:|:|||.|:||.|:||||.|.:|||...|||:|||.|.||||||:|:.
Mouse    79 VGWRYSDEEEDLRTELNLLRKYSFHKNIVTFYGAFFKLNPPGHQHQLWMVMELCAAGSVTDVVRM 143

  Fly   127 TKGQSLKEEWIAYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGR 191
            |:.|||||:||||||||||:||::||:::||||||||||||||.:||||:||||||||:.||.||
Mouse   144 TRNQSLKEDWIAYICREILQGLAHLHAHQVIHRDIKGQNVLLTHDAEVKIVDFGVSAQVSRTNGR 208

  Fly   192 RNTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNS 256
            ||:|||||||||||||.|||:|..:||.|||:||:||||:||||..||||.|.|:.||.:|.|.:
Mouse   209 RNSFIGTPYWMAPEVIHCDEDPRCSYDYRSDVWSVGITAIEMAEGAPPLCKLQPLEALCVILREA 273

  Fly   257 PPRLKSKKWSKKFHGFIDTVLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQ 321
            .|::||..||:||..|::..::|::..||.:.|:|.|.|:.|...:|:|...|..|:....::::
Mouse   274 APKVKSSGWSRKFQNFMENCMIKNFLFRPTSGNMLLHPFVHDIKNERRVVESLTKHLTGIIQKRE 338

  Fly   322 EK-----------EREDY---RYSGSDNDDDEPQLAGEHSSIVQAPGGDTLRRNFQQIQEGRLAA 372
            :|           .:|.|   |:.|       |....|...:..:.....||....:..:.|...
Mouse   339 KKGIPVAFEGEEAAKEQYITRRFRG-------PSCTPELLRVPTSSRCRPLRVLHGEPPQPRWLP 396

  Fly   373 EQQQQHHLMAQAQAQAAAAHAAAQAQ---AQLQQQQQQAAAAAAAAA----------HAAQQAQQ 424
            :|:.......|...:||.......:|   ::|..:|.:.|.....||          .|..|..:
Mouse   397 DQEDPQDQELQQLQKAAGVFMPLHSQDNTSKLFPKQVEVAPYLRGAAQVVMPVLVQVEAPPQVSK 461

  Fly   425 AAQQAQAQQPQANRQPKPPSR------QQVEEPGPPARPPQRLIVVPDPPHANRPLPPTPKCGEP 483
            |||..::...|.|:...|..:      ||.:........|:.|..||:........|..|:
Mouse   462 AAQMLKSLPTQDNKATSPEVQAPVAEGQQAQHEALETEQPKDLDQVPEEFQGQDRAPEQPR---- 522

  Fly   484 AGQTPQQQQRNSQNNFKPSLPP---RRPEP---QPQTAAGGQGSQQQAQPEA------------- 529
            .||..:|||   .:|..|..||   |.||.   |.:.....|...:..:||.
Mouse   523 QGQAAEQQQ---IHNPVPEQPPEEDREPEQAEVQEEAVEPPQAEIEDKEPEVVQVHAQVLLPLLS 584

  Fly   530 -------PPRNNRQ--------------SSGLSSSGGSASGG-----GGSSKPAAALPQQSNNHL 568
                   |...:||              :.........|.|.     .|.|:.....|   |..:
Mouse   585 QNRHVLLPLHLDRQLLIPVGEQNEEVPRAQAWDLEASRAVGAVQALIEGLSRDLLRAP---NAFV 646

  Fly   569 GQPVNPLDP-LDSSDSD---SEPDEPNDRARNDGTLLASDPPKPL-------PGLGPVSE----D 618
            .:|:.||.. |::..:|   :|| ||..:.::....|.....|.|       ..|..:.:    |
Mouse   647 TKPLGPLQIFLENLSTDGFYTEP-EPTQKKKSKVASLRKAIAKRLRPKRFRAKALWRLEDFEFSD 710

  Fly   619 ANTTTPLSHGSGGPPNRPLPPTPDDDDQAGDRTLIMKRKLEQNINRLQKSASTSQANVTPSRRGD 683
            ..|:....|                            |:.|...|:.::     |.....:.|.|
Mouse   711 VETSRRRRH----------------------------RRWEDIFNQHEE-----QLRRVENDRED 742

  Fly   684 ESNLLRDWDFDRFF----------PKNANGPRGS---GRGSPTTTASLSRSSQLSTLKVDTKLQR 735
            :|:     |.|..|          |..|| |.|:   .|.:| ...:.:|:.::. .......:.
Mouse   743 DSS-----DNDEVFHSIQAEVQIEPHAAN-PAGNEVHERSAP-MPCNRNRTHRVK-FSPSVGEEE 799

  Fly   736 ASVAEAITRPVPRGYQPLKAEPSASQSIAKEQGSASGSGSGSGSASGSGSGGSTNSPAHKRQDS- 799
            .|:.||  :|..:..||:...|   ::....|...:.|.|.|...|......|.:||.:...|.
Mouse   800 PSLEEA--QPQQQQQQPMNIRP---RNCLNPQNFQAQSDSSSEEDSPVTRRKSQSSPPYSTIDQK 859

  Fly   800 ---DSRLPTNFERGFRRENSDFFPLAKRYSAVFSGASASGSTAGSPSAQALQRSSAVYQRNSIYS 861
               |..:|..|:.|                                     :.|..||..|....
Mouse   860 LLIDIHVPDGFKVG-------------------------------------KISPPVYLTNEWVG 887

  Fly   862 SSISSKSKEND--VPGAPGAAAAGTATASAKPGPAAATTTATKGAAPKTSKSLANFHFLRPRREK 924
            .:..|:...:|  :|..|       |....:.|.......|...|  ...:.:||..:..||
Mouse   888 YNALSEIFWDDWIMPTRP-------ARPPEEDGDYVELYDADANA--NGDEEVANGAYEDPR--- 940

  Fly   925 TESVIVLQNAAVRAQRLQQLQQQQQQQQLQQQQQQQN--RGGGGGGGGGGGGGGSSGVGADGTGL 987
                                ........:..|..|.|  .|.|..|..||..||:.|...:|...
Mouse   941 --------------------DGANGHDDMNNQLDQANGYEGHGAAGYNGGDVGGNHGAAFNGPRA 985

  Fly   988 GTPGTRTSSVLPDLLSQASPATPPRHDKSSSEEYQAAISSSVHS---------------TPSKSF 1037
            ..|                               :|.|..:.|:               ..:::|
Mouse   986 NYP-------------------------------RAGILKNGHNDGRALNRGAFGVFGDNAARAF 1019

  Fly  1038 IASSGSGGLGLGGGTVVGGVIISSNHSPQSTISLASSSSNSRQNSPKNSISKTRSSSSITNLLHK 1102
            ..::|..|...|            ||        .::..|.|.|..:.:..:...:.:.....|.
Mouse  1020 HGAAGEAGAAFG------------NH--------GANRGNGRGNRNREANGRNEENGAFGRDQHV 1064

  Fly  1103 SASSSSANLHHLTPCSSTSSASISNPLPPHAYALQQ---KQRSFLTFGFGAGGSGPSRRE--SHV 1162
            .....    |..:...:.:|.||:  |...::..:|   :..|..|.||..|.|.|...:  |.:
Mouse  1065 FPEFE----HEESDRGTETSDSIA--LEITSFDGEQNSGRPVSSTTMGFPIGRSSPRGSDFGSDI 1123

  Fly  1163 NVNVTPTSHEAANDTPEIRKYKKRFNSEILCAALWGVNLLIGTENGLMLLDRSGQGKVYQLISRR 1227
            :.|           :|.:..|:|.|:||:.|.:|||||||:||::.|.|:||||:.::.:||.||
Mouse  1124 SYN-----------SPILHVYEKDFSSEVYCGSLWGVNLLLGTQSHLYLMDRSGKAEIVKLIKRR 1177

  Fly  1228 RFQQMEVLEGQNILVTISGKKNRVRVYYLSWLKSKILRTDGLSDQVE-----RRNGWINVGDLQG 1287
            .|:|::|:|..|:|:||||||||:|||:||||::|||..|..|.:.:     :......:..|.|
Mouse  1178 PFRQIQVVEQLNLLITISGKKNRLRVYHLSWLRNKILNNDPKSKKRQKAMRKKEEACKAIDKLIG 1242

  Fly  1288 AVHFKIVKYERIKFLVIALKDSIEIYAWAPKPYHKFMA--------------------------- 1325
            ..||.::::|...::.:|:|.||.::|||||.:.:..|
Mouse  1243 CEHFSVLQHEETTYIAVAVKSSIHLFAWAPKSFDENTAIKVLCIDQSADSEGDYMSYEAYIRILA 1307

  Fly  1326 ----------FKNFGELEH------------RPLLVDLTIEDQSRLKVIYGSAEGFHAVDLDSAE 1368
                      ||...||.|            :||.|||.:..:..||:.:.||.|:|.:|.:|..
Mouse  1308 KIQAADPANRFKRPDELLHLLKLKVFPTRDLKPLTVDLAVGSEKTLKIFFSSANGYHIIDAESEV 1372

  Fly  1369 VYDIYLPKHTQGAIIPHCIVALPNSNGMQLLLCYDNEGVYVNTVGRVSKNIVLQWGEMPTSVAYI 1433
            :.::.||.::...|||..:|.||:..|:.::|..:.|........::.|.|:..|.::|:|||:.
Mouse  1373 MSEVTLPNNSLEIIIPQNVVILPDCLGLGVMLSLNAEAASEEANEQLLKKILDVWKDIPSSVAFE 1437

  Fly  1434 GTGQIMGWGNKAIEIRSVESGHLDGVFMHKKAQRLKFLCERNDKVFFSSAKGASSCQIYFMTLNK 1498
            .|.:|.||..||||:||::|..|:.....:..::|:|||.|.||:||:|.......::|.|:|.|
Mouse  1438 CTKRITGWDQKAIEVRSLQSTILENELKRRSIKKLRFLCARGDKMFFASTLSNDHSRVYLMSLGK 1502

  Fly  1499  1498
            Mouse  1503  1502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	166/294 (56%)
		CNH	1183..1484	CDD:214481	124/354 (35%)
Nrk	XP_006528613.1	Protein Kinases, catalytic domain	14..313	CDD:473864	168/298 (56%)
		rne	<430..578	CDD:236766	36/154 (23%)
		CNH	1147..1478	CDD:459938	111/330 (34%)