DRSC/TRiP Functional Genomics Resources

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Protein Alignment: sls and Muc6

Sequence 1:NP_001261304.1 Gene:sls FlyBaseID:FBgn0086906 Length:18468 Species:Drosophila melanogaster
Sequence 2:NP_001355882.1 Gene:Muc6 MGIID:2663233 Length:2813 Species:Mus musculus

Alignment Length:1950 Identity:380/1950 (19%)
Similarity:606/1950 (31%) Gaps:575/1950 (29%)


  Fly  7685 SETTIQCEQKE-----------------TLAHETSAELPQSETLEQIEESLSTYETLPIQNLSKD 7732
            :|....|.|.|                 ||...|:...|.:||....|...||....|       
Mouse  1175 TEGCYNCSQNEYFDHSEGTCVPCAPPTTTLPPTTTGSQPTTETTISTEFHSSTSANTP------- 1232

  Fly  7733 TLQTVAVSVTTELSTPSPTASRVQEEI---------------LPQKVLAINEEVLPLDEFGLRKE 7782
                ||.|....|.||.|:|....||:               .||..:|......|.....:.|.
Mouse  1233 ----VAPSYLPGLPTPPPSAPSSTEELTVWTTPKESTVSSGEYPQTTMAATPPTSPWPPTSIPKS 1293

  Fly  7783 SPRPKENKLTENIEVRLKHALNVSHAKTAESSKELPSKIPKSVKAQRKMKESRSLVVEAPNAEEA 7847
            :|       ||         |.|:.|    :||...|.:..|.|...::.||.::         .
Mouse  1294 TP-------TE---------LPVTQA----TSKPTASSLSSSTKTTAELTESTTV---------T 1329

  Fly  7848 IEDLKPLKAVSQEVQSDILFSHEITEEQHQA----LETIEKLKPTSAIED-----TVQQKLLSQE 7903
            :..|.|..:.||...|....:      |||:    |.||.|. ||:.:.|     |......|..
Mouse  1330 LLTLMPGMSTSQGKTSASYTT------QHQSTSFHLTTISKW-PTNGVSDTPGVHTSSGTPSSSH 1387

  Fly  7904 ELIIAEVLPSETVGRDVTDVRPP-GETIS-----PRLTPNMSLCITECQPEDSIGEMQQA-AKER 7961
            ...|....|::.|........|| |.::.     |.|:...:..:|   |...:.....| ..|.
Mouse  1388 ATHITYTPPTQVVSSITHSTGPPLGTSVQTTINFPTLSAPQTSLVT---PHPGLSSSSTALTSEI 1449

  Fly  7962 METPSMSVTESKAVGGQELEVLENVDH-------------MPLITQPTKGLADYTIKAEEVPVQV 8013
            ::||    |.|:.|.....:.:.:..|             .||||..|..:           .|.
Mouse  1450 LKTP----TSSQMVSSASPQTIFSSIHPKTTLEATTPQHTAPLITSITSSI-----------TQA 1499

  Fly  8014 QEIITFDSLERETVAKTQTAKSNALELFELSEGLVSSTADSHSPIAEDLPIFEKDVKEATIDMQM 8078
            |...:.|        ||.|::.:.           .||..:|.  :..||......| :|:.:..
Mouse  1500 QSSFSTD--------KTYTSQHSQ-----------PSTMTAHQ--SRSLPTVTTSTK-STMGLTG 1542

  Fly  8079 QHHV-TTSETVSNENAVKDLKAVDTPKMAEGTLGQSSALTIGETQQMNLVETTVELIEPNVEST- 8141
            ...| |||.|.|:.         .||:    |....|.:.:..|:     .||...:|.:|::| 
Mouse  1543 TPPVHTTSGTTSSP---------QTPR----TTHPFSTVAVSNTK-----HTTGVSLETSVQTTI 1589

  Fly  8142 -KPAKGALTEAYGT----AESNEETLLESLGLVPDDNRKIEQGKVNISEGEYVAKVQTTTVTDTE 8201
             .|...|...:..|    :.::..|....:.:.|.....:.....:.:.|    .:..||:..|.
Mouse  1590 ASPTPSAPQTSLATHLPFSSTSSVTPTSEVIITPTPQHTLSSASTSTTTG----NILPTTIGQTG 1650

  Fly  8202 GEFVSVAPKLVNPKFDFVEQSALQIKQDTTVEKEEILSSNIELAPQLATSNMFPAELKVTSIYEV 8266
            ....|| |.:      :...:..|.|...:.::....:|    ||.|       :|....:.::.
Mouse  1651 SPHTSV-PVI------YTTSAITQTKTSFSTDRTSTPTS----APHL-------SETSAVTAHQS 1697

  Fly  8267 QPGLTSSDIITEQTKSVSANQVFETMSIGVTSKPDMLESTSHIDAFQHPEFKTGDTILDENQQPL 8331
            .|...|::.| :.|.|.:...|..|.| |.||.|....:|       ||.               
Mouse  1698 TPTAVSANSI-KPTMSSTGTPVVHTTS-GTTSSPQTPRTT-------HPS--------------- 1738

  Fly  8332 EVTNVQITESSTDIIDVLPNQKLTKAETVTDGFKYAEG-----LVVLPMESTIDKTEDTKPTAVN 8391
              |.|.:  |.|.....||:.  |...|.|: |....|     ...||:.||:..|..|:  .:|
Mouse  1739 --TTVAV--SGTVHTTGLPSG--TSVHTTTN-FPTHSGPQSSLSTHLPLFSTLSVTPTTE--GLN 1794

  Fly  8392 ADISMHQQFGTDVREQEPLESTL-TRTEDLKP--------QTQTTESQFGLLQSLETSSCVTLEG 8447
            ...|.|..  :......||.:.| |..|..:|        .|.|..:|.....|.:.:|...|..
Mouse  1795 TPTSPHSL--SVASTSMPLMTVLPTTLEGTRPPHTSVPVTYTTTAATQTKSSFSTDRTSAPHLSQ 1857

  Fly  8448 ESVLSVKERHPEQSAAI--GTSSALQVANI--TRPQHMESLDRLDEQKVPYYQANVNIGEITLPN 8508
            .|.::     |.||..|  .|:|.:....:  |.|.|..|                  |..:.| 
Mouse  1858 PSTVT-----PTQSTPIPATTNSLMTTGGLTGTPPVHTTS------------------GTTSSP- 1898

  Fly  8509 VEKIDSFDVLSDLNTPDYNKSSKGRVQLIESTTSLKTTTAVVSESTEELKDLNITQPVHIKPKPY 8573
                         .||        |.....||.::..||.....|.|......|..|....|   
Mouse  1899 -------------QTP--------RTTHPFSTVAVSNTTHTTGVSLETSVQTTIASPTPSAP--- 1939

  Fly  8574 ESDQKISISEQTNVLEHV--SSLNPVLPALETIQSSIKSLHEINVRETDILEKEESLKDVDHISG 8636
                      ||::..|:  ||.:.|.|..|.|.:.... |.::...|                 
Mouse  1940 ----------QTSLATHLPFSSTSSVTPTSEVIITPTPQ-HTLSSAST----------------- 1976

  Fly  8637 RLAKIILDCTTG------IAQVRQEETLEHEEDLKAPLIPLEKAIPASSELHRLPLTEYVQEQQG 8695
                   ..|||      |.:.....|       ..|:|....||                    
Mouse  1977 -------STTTGNILPTTIGKTGSPHT-------SVPVIYTTSAI-------------------- 2007

  Fly  8696 TSDMTDFKVSNKCASPNIDHLYET------KSSEMIVYDSSINSVDSEFPAGIV---------PQ 8745
            |...|.|.......|.:..||.||      :|:...|..:||....|.....:|         ||
Mouse  2008 TQTKTSFSTDRTSTSTSAPHLSETSAVTAHQSTPTAVSANSIKPTMSSTGTPVVHTTSGTTSSPQ 2072

  Fly  8746 KSLVPFRHTMVTENVAFNASENFEILSADQQIATNV--------QDSLSQSIIAEDQIAF-ETEQ 8801
            ..    |.|..:..||.:.:.:...|.:...:.|..        |.|||..:.....::. .|.:
Mouse  2073 TP----RTTHPSTTVAVSGTVHTTGLPSGTSVHTTTNFPTHSGPQSSLSTHLPLFSTLSVTPTTE 2133

  Fly  8802 NLGLETTP-------------THKPKLLKDDQNLHAKLVDEATVYEAMGQEQKVDKYNIQQAEIT 8853
            .|...|:|             |..|..|:..:..|..:   ...|......|....::..:....
Mouse  2134 GLNTPTSPHSLSAASTSMPLMTVLPTTLEGTRPPHTSV---PVTYTTTAATQTKSSFSTDRTSTP 2195

  Fly  8854 HDLPQVYATDLQQTFEAEKEITTREQSYVAATTDIIPSRLGLAMTTKTHPVEGIDVLLSSP---- 8914
            |         |.|:    ..:|..:.:.:.|||:...:.:||..|...|...|...:..:|    
Mouse  2196 H---------LSQS----STVTPTQPTPIPATTNSPMTTVGLTGTPVVHTPSGTSSIAHTPHTTH 2247

  Fly  8915 --PKPSLAQTNYEETQHEVRVRE-------TQAIEESEELTDGRLLPVSAVESIDSTFKVTSDSQ 8970
              |..:.:.|.. .|..:.|..|       |.:..::..:|.   ||..:..|:..|.::...|.
Mouse  2248 SLPTAASSSTTL-STAPQFRTSEQSTTTFPTPSAPQTSLVTS---LPPFSTSSVSPTDEIHITST 2308

  Fly  8971 QPPVFDKELSIPTVSPLEARAKPSLNLLQGTTTFDVIPLESSVLLKDTHV--------AVQKAQQ 9027
            .|         .|||.: :.::|...:||.|......|..|:.:...|..        :.::...
Mouse  2309 NP---------HTVSSV-SMSRPVSTILQTTIEVTTPPNTSTPVTHSTSATTEAQGSFSTERTST 2363

  Fly  9028 EYVAQVESNKVHVQMDNLVMHKEDIFENAEIENFCKPITEGTQLETVVIEVVPIDNVGGIHLAPQ 9092
            .|::...|..||                   ::...|:....:....|....|:....|...:||
Mouse  2364 SYLSHPSSTTVH-------------------QSTAGPVITSIKSTMGVTGTPPVHTTSGTTSSPQ 2409

  Fly  9093 PSTLLATLTSTDIVNQSHVIDTQVPLEMESEAQAPLDNIAQARIKSAEDHVHTNV-SEVNVYEQT 9156
            .......:::..|...:.:..|.....|::....|..:..|..:.:......|:| |...::.  
Mouse  2410 TPHSTHPISTAAISRTTGISGTPFRTPMKTTITFPTPSSLQTSMATLFPPFSTSVMSSTEIFN-- 2472

  Fly  9157 KAIQDQNKHGLFVKVSKNSDTSKAYLTTIQSTFLKEDILPKPNILQDTAQAAADELQSLVTEEVV 9221
               ...|.|.: ...|.:...|.:..|||:.|...:..:...|....|.||.:    |..|... 
Mouse  2473 ---TPTNPHSV-SSASTSRPLSTSLPTTIKGTGTPQTPVSDINTTSATTQAHS----SFPTTRT- 2528

  Fly  9222 SVSSIQETYELKIPLQKTANLTQQTPQNSVNVCQQLAYEETPDIAFEPHALTRATT---SSVPTF 9283
                  .|..|.:|...|:.||..:...|.     |.|..||........||..|.   ||.|||
Mouse  2529 ------STSHLSLPSSMTSTLTPASRSAST-----LQYTPTPSSVSHSPLLTTPTASPPSSAPTF 2582

  Fly  9284 LKPAENATVNIYENIEGHGDFKPGTVNLT---SNSNLNSELVVSVVQEVTSVPSLGSLATVEPQE 9345
            :.|...:|| |...:.        |:::|   |:...:|..::|..:..:.||:..|.:      
Mouse  2583 VSPTAASTV-ISSALP--------TIHMTPTPSSRPTSSTGLLSTSKTTSHVPTFSSFS------ 2632

  Fly  9346 LKAMPVTKSSTNLAYSEEGGIPYVQITVEEAKLVNTRADVEENITSVTTEQPNMCIAAS----IQ 9406
                  :||:|                              .::||:||:.....:.:|    ..
Mouse  2633 ------SKSTT------------------------------AHLTSLTTQAATSGLLSSTMGMTN 2661

  Fly  9407 LPAIEEKKLENALQTPQFASESILKTSPQISRNAHFETRTHEEEYSTTTESLVTTQALRDDIDST 9471
            ||:.....:.:..:.|   ..|.|.||..:||:.           |.|..|..:|.....:.||:
Mouse  2662 LPSSGSPDINHTTRPP---GSSPLPTSAFLSRST-----------SPTGSSSPSTPVSSSNPDSS 2712

Known Domains:


GeneSequenceDomainRegion External IDIdentity
slsNP_001261304.1 I-set 87..174 CDD:254352
Ig 109..175 CDD:143165
Ig 254..334 CDD:299845
I-set 255..344 CDD:254352
I-set 372..462 CDD:254352
Ig 390..463 CDD:299845
Ig 471..561 CDD:299845
I-set 471..560 CDD:254352
I-set 618..709 CDD:254352
Ig 645..705 CDD:143165
DUF1136 715..741 CDD:284093
IG_like 762..843 CDD:214653
Ig 779..835 CDD:143165
I-set 890..982 CDD:254352
Ig 918..979 CDD:143165
DUF1136 988..1014 CDD:284093
I-set 1024..1116 CDD:254352
Ig 1058..1113 CDD:143165
I-set 1158..1250 CDD:254352
Ig 1178..1246 CDD:143165
DUF1136 1256..1282 CDD:284093
I-set 1291..1380 CDD:254352
IGc2 1304..1372 CDD:197706
DUF1136 1388..1414 CDD:284093
I-set 1424..1515 CDD:254352
Ig 1442..1513 CDD:143165
DUF1136 1522..1548 CDD:284093
I-set 1558..1645 CDD:254352
IGc2 1571..1639 CDD:197706
DUF1136 1655..1679 CDD:284093
I-set 1691..1782 CDD:254352
IGc2 1718..1772 CDD:197706
DUF1136 1788..1814 CDD:284093
I-set 1824..1916 CDD:254352
IGc2 1838..1906 CDD:197706
DUF1136 1922..1948 CDD:284093
I-set 1958..2049 CDD:254352
Ig 1985..2044 CDD:143165
I-set 2089..2181 CDD:254352
IGc2 2103..2171 CDD:197706
DUF1136 2187..2213 CDD:284093
I-set 2222..2314 CDD:254352
IGc2 2236..2304 CDD:197706
DUF1136 2320..2346 CDD:284093
I-set 2356..2448 CDD:254352
Ig 2384..2445 CDD:143165
DUF1136 2454..2480 CDD:284093
I-set 2488..2580 CDD:254352
Ig 2516..2576 CDD:143165
I-set 2622..2714 CDD:254352
IGc2 2636..2704 CDD:197706
I-set 2754..2844 CDD:254352
Ig 2771..2840 CDD:143165
IGc2 2908..2974 CDD:197706
I-set 3029..3120 CDD:254352
Ig 3057..3116 CDD:143165
I-set 3130..3220 CDD:254352
Ig 3148..3219 CDD:143165
I-set 3263..3354 CDD:254352
I-set 3401..3493 CDD:254352
Ig 3429..3490 CDD:143165
I-set 3539..3630 CDD:254352
Ig 3556..3625 CDD:143165
I-set 3676..3767 CDD:254352
IGc2 3690..3758 CDD:197706
I-set 3811..3900 CDD:254352
Ig 3828..3899 CDD:143165
I-set 3954..4046 CDD:254352
Ig 3963..4042 CDD:299845
I-set 4092..4180 CDD:254352
Ig 4102..4172 CDD:299845
I-set 4394..4483 CDD:254352
Ig 4411..4480 CDD:143165
I-set 4497..4581 CDD:254352
Ig 4519..4580 CDD:143165
I-set 4604..4693 CDD:254352
Ig 4621..4691 CDD:299845
I-set 4702..4792 CDD:254352
Ig 4702..4791 CDD:299845
COG4372 4996..>5260 CDD:226809
I-set 6536..6622 CDD:254352
Ig 6554..6622 CDD:143165
Ig 6654..6725 CDD:143165
I-set 6743..6829 CDD:254352
Ig 6760..6829 CDD:299845
I-set 6841..6928 CDD:254352
Ig 6858..6927 CDD:143165
I-set 6942..7033 CDD:254352
IGc2 6957..7023 CDD:197706
I-set 7066..7157 CDD:254352
Ig 7084..7153 CDD:143165
IGc2 7224..7289 CDD:197706
Ehrlichia_rpt 14571..15030 CDD:118064
SH3_p47phox_like 16753..16807 CDD:212790
I-set 16841..16931 CDD:254352
Ig 16858..16931 CDD:299845
I-set 16965..17060 CDD:254352
IGc2 16978..17050 CDD:197706
I-set 17068..17152 CDD:254352
Ig_2 17078..17152 CDD:290606
IG_like 17170..17253 CDD:214653
Ig 17180..17250 CDD:143165
I-set 17260..17342 CDD:254352
IGc2 17274..17331 CDD:197706
I-set 17347..17432 CDD:254352
IGc2 17367..17423 CDD:197706
I-set 17437..17521 CDD:254352
Ig <17468..17521 CDD:299845
I-set 17528..17611 CDD:254352
Ig 17553..17602 CDD:143165
I-set 17618..17708 CDD:254352
Ig 17635..17708 CDD:299845
FN3 17712..17791 CDD:238020
I-set 17813..17898 CDD:254352
Ig 17830..17894 CDD:143165
Ig 17922..17994 CDD:299845
FN3 17998..18090 CDD:238020
FN3 18098..18189 CDD:238020
FN3 18207..18298 CDD:238020
FN3 18307..18398 CDD:238020
Muc6NP_001355882.1 VWD 45..194 CDD:306577
C8 232..298 CDD:337178
TIL 303..358 CDD:334697
VWC_out 360..>404 CDD:214565
VWD 387..550 CDD:214566
C8 589..661 CDD:214843
TIL 665..722 CDD:334697
TIL 765..828 CDD:334697
VWC 830..887 CDD:327433
VWD 869..1020 CDD:306577
C8 1057..1129 CDD:214843
ROM1 1406..>1624 CDD:227709 54/276 (20%)
Herpes_BLLF1 <1553..1968 CDD:282904 111/548 (20%)
Herpes_BLLF1 <1895..2353 CDD:282904 105/579 (18%)
PHA03247 <2202..2624 CDD:223021 93/486 (19%)
CT 2729..2808 CDD:214482
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
eggNOG 1 0.900 E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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