DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trbl and Prkaa2

DIOPT Version :9

Sequence 1:	NP_524672.1	Gene:	trbl / 43999	FlyBaseID:	FBgn0028978	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_076481.1	Gene:	Prkaa2 / 78975	RGDID:	620893	Length:	552	Species:	Rattus norvegicus

Alignment Length:	295	Identity:	83/295 - (28%)
Similarity:	134/295 - (45%)	Gaps:	48/295 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 TGEQFLCRIVN-------EPLHKVQRAYFQLQQHDEELRRSTIYGHPLIRPVHDIIPLTKDRTYI 204
            ||.:...:|:|       :.:.|::|          |::...::.||.|..::.:|....| .::
  Rat    38 TGHKVAVKILNRQKIRSLDVVGKIKR----------EIQNLKLFRHPHIIKLYQVISTPTD-FFM 91

  Fly   205 LIAPVPQERDSTGGVTGVYENLHTYIRHAKRLCETEARAIFHQICQTVQVCHRNGIILRDLKLKR 269
            ::..|      :||      .|..||....|:.|.|||.:|.||...|..|||:.::.||||.:.
  Rat    92 VMEYV------SGG------ELFDYICKHGRVEEVEARRLFQQILSAVDYCHRHMVVHRDLKPEN 144

  Fly   270 FYFIDEARTKLQYESLEGSMILDGEDDTLSDKIGCPLYTAPELLCPQQTYKGKPADMWSLGVILY 334
            .....:...|:....| .:|:.|||  .|....|.|.|.|||:: ..:.|.|...|:||.|||||
  Rat   145 VLLDAQMNAKIADFGL-SNMMSDGE--FLRTSCGSPNYAAPEVI-SGRLYAGPEVDIWSCGVILY 205

  Fly   335 TMLVGQYPFYEKANCNLITVIRHGNVQIPLTLSKSVRWLLLSLLRKDYTERMTASHIFLTPWLRE 399
            .:|.|..||.::....|...||.|...||..|::|:..||:.:|:.|..:|.|...|....|.::
  Rat   206 ALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSIATLLMHMLQVDPLKRATIKDIREHEWFKQ 270

  Fly   400 QRPFHMYLPVDVEVAEDWSDAEEDEGTAADAMDDD 434
            ..|.:::              .||....|:.:||:
  Rat   271 DLPSYLF--------------PEDPSYDANVIDDE 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trbl	NP_524672.1	PKc_like	131..397	CDD:328722	76/256 (30%)
Prkaa2	NP_076481.1	STKc_AMPK_alpha	13..268	CDD:270981	76/256 (30%)
		S_TKc	16..268	CDD:214567	76/256 (30%)
		UBA_AID_AAPK2	285..349	CDD:270587	3/7 (43%)
		AIS. /evidence=ECO:0000250	291..376		0/1 (0%)
		AMPKA2_C	395..550	CDD:213385
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..520
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910