Protein Alignment trbl and PRKAA2

DIOPT Version :10

• Sequence 1: NP_524672.1
• Gene: trbl / 43999
• FlyBaseID: FBgn0028978
• Length: 484
• Species: Drosophila melanogaster
• Sequence 2: NP_006243.2
• Gene: PRKAA2 / 5563
• HGNCID: 9377
• Length: 552
• Species: Homo sapiens
• Alignment Length: 295
• Identity: 84/295 - (28%)
• Similarity: 133/295 - (45%)
• Gaps: 48/295 - (16%)

  Fly   147 TGEQFLCRIVN-------EPLHKVQRAYFQLQQHDEELRRSTIYGHPLIRPVHDIIPLTKDRTYI 204
            ||.:...:|:|       :.:.|::|          |::...::.||.|..::.:|....| .::
Human    38 TGHKVAVKILNRQKIRSLDVVGKIKR----------EIQNLKLFRHPHIIKLYQVISTPTD-FFM 91

  Fly   205 LIAPVPQERDSTGGVTGVYENLHTYIRHAKRLCETEARAIFHQICQTVQVCHRNGIILRDLKLKR 269
            ::..|      :||      .|..||....|:.|.|||.:|.||...|..|||:.::.||||.:.
Human    92 VMEYV------SGG------ELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPEN 144

  Fly   270 FYFIDEARTKLQYESLEGSMILDGEDDTLSDKIGCPLYTAPELLCPQQTYKGKPADMWSLGVILY 334
            .........|:....| .:|:.|||  .|....|.|.|.|||:: ..:.|.|...|:||.|||||
Human   145 VLLDAHMNAKIADFGL-SNMMSDGE--FLRTSCGSPNYAAPEVI-SGRLYAGPEVDIWSCGVILY 205

  Fly   335 TMLVGQYPFYEKANCNLITVIRHGNVQIPLTLSKSVRWLLLSLLRKDYTERMTASHIFLTPWLRE 399
            .:|.|..||.::....|...||.|...||..|::||..||:.:|:.|..:|.|...|....|.::
Human   206 ALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270

  Fly   400 QRPFHMYLPVDVEVAEDWSDAEEDEGTAADAMDDD 434
            ..|.:::              .||....|:.:||:
Human   271 DLPSYLF--------------PEDPSYDANVIDDE 291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trbl	NP_524672.1	Protein Kinases, catalytic domain	131..397	CDD:473864	77/256 (30%)
PRKAA2	NP_006243.2	STKc_AMPK_alpha	13..268	CDD:270981	77/256 (30%)
		UBA_AID_AAPK2	285..349	CDD:270587	3/7 (43%)
		AIS. /evidence=ECO:0000250|UniProtKB:Q13131	291..376		0/1 (0%)
		AMPKA2_C	395..550	CDD:213385
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..521