Protein Alignment trbl and Melk

DIOPT Version :10

• Sequence 1: NP_524672.1
• Gene: trbl / 43999
• FlyBaseID: FBgn0028978
• Length: 484
• Species: Drosophila melanogaster
• Sequence 2: NP_001382535.1
• Gene: Melk / 362510
• RGDID: 1308974
• Length: 643
• Species: Rattus norvegicus
• Alignment Length: 353
• Identity: 91/353 - (25%)
• Similarity: 142/353 - (40%)
• Gaps: 74/353 - (20%)

  Fly   140 LRCVDIFTGEQFLCRIVNE-----PLHKVQRAYFQLQQHDEELRRSTIYGHPLIRPVHDIIPLTK 199
            |.| .|.|||....:|:::     .|.:|:.....|    :.||      |..|..::.::. ||
  Rat    27 LAC-HILTGEMVAIKIMDKNALGSDLPRVKTEIDAL----KNLR------HQHICQLYHVLE-TK 79

  Fly   200 DRTYILIAPVPQERDSTGGVTGVYENLHTYIRHAKRLCETEARAIFHQICQTVQVCHRNGIILRD 264
            ::.::::...|      ||      .|..||....||.|.|.|.||.||...|...|..|...||
  Rat    80 NKIFMVLEYCP------GG------ELFDYIISQDRLSEEETRVIFRQILSAVAYVHSQGYAHRD 132

  Fly   265 LKLKRFYFIDEARTKLQYESLEGSMILD---------GEDDTLSDKIGCPLYTAPELLCPQQTYK 320
            ||.:...|.:..:.||          :|         .:|..|....|...|.||||: ..::|.
  Rat   133 LKPENLLFDENHKLKL----------IDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI-QGKSYL 186

  Fly   321 GKPADMWSLGVILYTMLVGQYPFYEKANCNLITVIRHGNVQIPLTLSKSVRWLLLSLLRKDYTER 385
            |..||:||:|::||.::.|..||.:.....|...|..|..::|..||.|...||..:|:.|...|
  Rat   187 GSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVDPKRR 251

  Fly   386 MTASHIFLTPWLREQRPFHMYLPVDVEVAEDWSDAEEDEGTAADAMDDDEEGLCPLGDKHEYEDI 450
            ::..::...||:.:          |.....:|.       :.|.....||:.:..|...|.....
  Rat   252 ISMKNLLNHPWILQ----------DYSCPIEWQ-------SKASLTHLDEDCITELSVHHRNSRQ 299

  Fly   451 GVEPL------DYTRST--LQMAQNANG 470
            .:|.|      |:..:|  |.:|:.|.|
  Rat   300 TMEDLISSWQYDHLTATYLLLLAKKARG 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trbl	NP_524672.1	Protein Kinases, catalytic domain	131..397	CDD:473864	75/270 (28%)
Melk	NP_001382535.1	STKc_MELK	7..263	CDD:270980	75/270 (28%)
		UBA_MELK	281..332	CDD:270526	12/47 (26%)
		MELK_C	547..641	CDD:213383