Protein Alignment trbl and TRIB2

DIOPT Version :10

• Sequence 1: NP_524672.1
• Gene: trbl / 43999
• FlyBaseID: FBgn0028978
• Length: 484
• Species: Drosophila melanogaster
• Sequence 2: NP_067675.1
• Gene: TRIB2 / 28951
• HGNCID: 30809
• Length: 343
• Species: Homo sapiens
• Alignment Length: 350
• Identity: 121/350 - (34%)
• Similarity: 181/350 - (51%)
• Gaps: 61/350 - (17%)

  Fly   111 SAQPS-----HISAAVAAKTPASYRHLVDLTASNL-----------RCVDIFTGEQFLCRIVNEP 159
            ||:||     ::.:....:|| :..|.|......|           |.|.:.:||:.:|::
Human    32 SAEPSQSFSPNLGSPSPPETP-NLSHCVSCIGKYLLLEPLEGDHVFRAVHLHSGEELVCKV---- 91

  Fly   160 LHKVQRAYFQLQQHDEELRRS-TIYGHPLIRPVHDIIPLTKDRTYILIAPVPQERDSTGGVTGVY 223
                    |.:..:.|.|... .:..|..|..:.:|| |.:.:.|:..     ||.        |
Human    92 --------FDISCYQESLAPCFCLSAHSNINQITEII-LGETKAYVFF-----ERS--------Y 134

  Fly   224 ENLHTYIRHAKRLCETEARAIFHQICQTVQVCHRNGIILRDLKLKRFYFIDEARTKLQYESLEGS 288
            .::|:::|..|:|.|.||..:|:||...|..||..|::||||||::|.|.||.||:::.||||.:
Human   135 GDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDA 199

  Fly   289 MILDGEDDTLSDKIGCPLYTAPELLCPQQTYKGKPADMWSLGVILYTMLVGQYPFYEKANCNLIT 353
            .||.|:||:||||.|||.|.:||:|....:|.||.||:|||||:|||||||:|||::....:|.:
Human   200 YILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFS 264

  Fly   354 VIRHGNVQIPLTLSKSVRWLLLSLLRKDYTERMTASHIFLTPWLREQRPFHMYLPVDVEVAEDWS 418
            .||.|...||.|||...:.|:.|:||::.:||:|:..|...||          ...|..|:....
Human   265 KIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPW----------FSTDFSVSNSAY 319

  Fly   419 DAEEDEGTAADAMDDD---EEGLCP 440
            .|:|    .:|.:..|   ||.|.|
Human   320 GAKE----VSDQLVPDVNMEENLDP 340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trbl	NP_524672.1	Protein Kinases, catalytic domain	131..397	CDD:473864	104/277 (38%)
TRIB2	NP_067675.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..50		4/17 (24%)
		PK_TRB2	67..308	CDD:270924	102/276 (37%)