Protein Alignment Pten and daf-18

DIOPT Version :10

• Sequence 1: NP_477422.2
• Gene: Pten / 43991
• FlyBaseID: FBgn0026379
• Length: 514
• Species: Drosophila melanogaster
• Sequence 2: NP_499926.1
• Gene: daf-18 / 176869
• WormBaseID: WBGene00000913
• Length: 962
• Species: Caenorhabditis elegans
• Alignment Length: 604
• Identity: 162/604 - (26%)
• Similarity: 244/604 - (40%)
• Gaps: 158/604 - (26%)

  Fly     5 ISLMSNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENH 69
            :..:.::.|..||..|.|.:.:..|||..||.|.|||:||||.. :|..|||......:.|...|
 Worm    42 VERIRHIFRTAVSSNRCRTEYQNIDLDCAYITDRIIAIGYPATG-IEANFRNSKVQTQQFLTRRH 105

  Fly    70 AQ-HYKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCK 133
            .: :.|::||.....||...|.|.|..:...||:||::||:..||.:...||:.|..:|:|||||
 Worm   106 GKGNVKVFNLRGGYYYDADNFDGNVICFDMTDHHPPSLELMAPFCREAKEWLEADDKHVIAVHCK 170

  Fly   134 AGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSSVPYSK 198
            |||||||.||||.|::.....|..:.|.:|...|||:.|||||||||||:.|:.||       .:
 Worm   171 AGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYYHKL-------RE 228

  Fly   199 VSLNVCEIRFSESSCVQNLGM-VE---------CSISV-LHDSATENAKPDRL---KT------- 242
            ..||...:|      :|.:|: ||         ..|.| :.:.:|...|||.|   |:
 Worm   229 RELNYLPLR------MQLIGVYVERPPKTWGGGSKIKVEVGNGSTILFKPDPLIISKSNHQRERA 287

  Fly   243 -------LPIDF------------QKSFVLTIKPSIP--VSGDVKFEL-----TKKSPDKIICHF 281
                   .|.:|            ::::...:....|  |.|||:.::     .||..|..|.|.
 Worm   288 TWLNNCDTPNEFDTGEQKYHGFVSKRAYCFMVPEDAPVFVEGDVRIDIREIGFLKKFSDGKIGHV 352

  Fly   282 WLNTFFVRNYSPCESDGTVN----KYIHTLSKSEIDDV---HKDSEHKRFSEEFKISIVFEAEN- 338
            |.||.|.     |  ||.:|    :|:........||.   .|:...:..:...||..  |..|
 Worm   353 WFNTMFA-----C--DGGLNGGHFEYVDKTQPYIGDDTSIGRKNGMRRNETPMRKIDP--ETGNE 408

  Fly   339 FSN--------DVQAEASEKERNENVLNFERSDYDSLSPNCYAEKKVL-----TAIVNDNTT--- 387
            |.:        .::...:|::..||..|:      .:.|..|...|:|     ..||.|:..
 Worm   409 FESPWQIVNPPGLEKHITEEQAMENYTNY------GMIPPRYTISKILHEKHEKGIVKDDYNDRK 467

  Fly   388 -----KSQT------------------IETLDHKDIVTKIQYDTSTNSKNTSTACKR-------K 422
                 ||.|                  .:..:|.......:.|.:..||:.:...|.       .
 Worm   468 LPMGDKSYTESGKSGDIRGVGGPFEIPYKAEEHVLTFPVYEMDRALKSKDLNNGMKLHVVLRCVD 532

  Fly   423 QPNSKTLLPSLNDSTKEEIKRNHIFNQPSIKKTDLI-----KW---------QNSEVHITSDTR- 472
            ..:||.:       .|.|:..|..|:..|.::...:     ||         :.:|:|.....|
 Worm   533 TRDSKMM-------EKSEVFGNLAFHNESTRRLQALTQMNPKWRPEPCAFGSKGAEMHYPPSVRY 590

  Fly   473 SINENKNINYNSYITCKQS 491
            |.|:.|   ||.  .|.::
 Worm   591 SSNDGK---YNG--ACSEN 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_477422.2	PTP_PTEN	31..189	CDD:350359	72/158 (46%)
		PTEN_C2	196..335	CDD:463081	41/192 (21%)
daf-18	NP_499926.1	PTP_PTEN	68..226	CDD:350359	72/158 (46%)
		PTEN_C2	233..>364	CDD:463081	32/143 (22%)