Protein Alignment Pten and tns3

DIOPT Version :10

• Sequence 1: NP_477422.2
• Gene: Pten / 43991
• FlyBaseID: FBgn0026379
• Length: 514
• Species: Drosophila melanogaster
• Sequence 2: XP_031760312.1
• Gene: tns3 / 100492216
• XenbaseID: XB-GENE-1011198
• Length: 1408
• Species: Xenopus tropicalis
• Alignment Length: 562
• Identity: 133/562 - (23%)
• Similarity: 232/562 - (41%)
• Gaps: 127/562 - (22%)

  Fly    25 EKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKF 89
            |:.|:||||||.:.||::.:|.....|....| |:||..:|:..|...|.:.|| ||:.|:::|.
 Frog     6 EECYELDLTYITERIISVSFPRSSSEEAYIHN-LQDVTCMLKSKHGDSYLVLNL-SEKRYELSKL 68

  Fly    90 RGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKK 154
            ...|....:.|.:.|.::.:...|..::.||..|..:||.:||:..:||.|.:|.:|:.|:.|..
 Frog    69 NTEVMDVGWPDFHAPPLDKMCTICKAMESWLNSDPLHVVVIHCRGERGRIGVVISSYMHFTNISA 133

  Fly   155 SADEALAWYDEKRTKDRKGVTI---PSQRRYVQYFSKLVCSSVPYSKVSLNVCEI------RFSE 210
            |||:||..:..|:..|.| |::   |||:|||.:.::|:......:.:.|.:..:      .|..
 Frog   134 SADQALDRFAMKKFIDDK-VSVLLQPSQKRYVNFLNELLSGLEKMNVMPLFLHSVILHGIPNFDS 197

  Fly   211 SSCVQNLGMVECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKKSPD 275
            :...|....:..::..::.|......|:.        |....:.|:|:..:.||:..:....|..
 Frog   198 ADRCQFFLKIYIAMQPVYTSGIYLVGPEN--------QGKIYIEIEPAQLIKGDIMLKCYHPSVT 254

  Fly   276 K-IICHFWLNTFFVRNYSP--CESDGTVNKYIHTLSKSEIDDVHKDSEHKRFSEEFKISIVFEA- 336
            : ::.....:|..:.::..  |:.|         |..:.|||        ||.|..:|.:||..
 Frog   255 RDLVFRLQFHTGAIHSHRVIFCKED---------LDHANIDD--------RFPEYGRIELVFSGG 302

  Fly   337 -----ENFSNDVQAEASEKERNENV-LNFERSD----YDS-----------------LSPNCYAE 374
                 |||.|           |:.| :::..||    :||                 |..:.||.
 Frog   303 PEKNPENFYN-----------NQGVTIDYNTSDPLIRWDSYENTNIVSEGFSHTQGPLDGSLYAR 356

  Fly   375 -KKVLTAIVNDNTTKSQT----IETLDHKDIVTKIQYDT--STNS-KNTSTACKRKQPNSKTLLP 431
             :|..|:  |..||.:.:    ..:.||.:....:..|:  ||.| ||..||.|....:.|.|.|
 Frog   357 VRKKSTS--NGITTVAGSGFPLTRSPDHSEHSLSVSSDSGHSTASIKNRVTAEKSGSISKKGLSP 419

  Fly   432 SLN------------DSTKEEIK------------------RNHIFNQPSIK--KTDLI--KWQN 462
            ...            :||...:|                  |.::.....:|  :||::  :..|
 Frog   420 QEKVELDQLLSGFGVESTMCSLKNIADGQSNYGGVERMISARIYVNGDAKLKDRETDILDDEMTN 484

  Fly   463 SEVHITSD--TRSINENKNINYNSYITCKQSSPKFNCGTEDG 502
            ::::....  |.|.:|..:.|.....:|.:||.  |....||
 Frog   485 NDLNSVDSLGTLSSSEGHHFNNIGNFSCHESSQ--NSLLSDG 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_477422.2	PTP_PTEN	31..189	CDD:350359	55/160 (34%)
		PTEN_C2	196..335	CDD:463081	23/147 (16%)
tns3	XP_031760312.1	PTP_tensin-3	12..170	CDD:350409	55/160 (34%)
		PTEN_C2	177..300	CDD:463081	23/147 (16%)
		SH2_Tensin_like	1132..1248	CDD:198181
		PTB_tensin	1272..1402	CDD:269924