DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Plap and DOA1

DIOPT Version :10

Sequence 1:NP_524666.2 Gene:Plap / 43978 FlyBaseID:FBgn0024314 Length:787 Species:Drosophila melanogaster
Sequence 2:NP_012709.1 Gene:DOA1 / 853667 SGDID:S000001696 Length:715 Species:Saccharomyces cerevisiae


Alignment Length:798 Identity:240/798 - (30%)
Similarity:373/798 - (46%) Gaps:124/798 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 YKLSCELLGHSMDVR-AVAVGPPTPEGRQTILSGSRDKSTKVWKPHGNEYLESLTLQDHKNFISY 71
            |:||..|.||..||| .|||..      ..:.|.|||.:.::|. ..:::|.:: :...:.|::.
Yeast     3 YQLSATLKGHDQDVRDVVAVDD------SKVASVSRDGTVRLWS-KDDQWLGTV-VYTGQGFLNS 59

  Fly    72 ICFLESERWICTASNDATI---CIYKQDGFVPLLTLKGHESTVCALSAGLEPRSLISGSWDKTAR 133
            :|:...:..:.....|..|   .::...|..||.||.||:..||:||  .:...:|||||||||:
Yeast    60 VCYDSEKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLS--FQDGVVISGSWDKTAK 122

  Fly   134 VWTISEAGDVSFVALEGHEAAVWAVATLK-EQRKYVTGGADRNIYYWNAKGEKLRLLKG-HTDCV 196
            ||   :.|.:.: .|:.|.|:||....:. .:.|::|..||:.|..|. ..:.::...| |.|.|
Yeast   123 VW---KEGSLVY-NLQAHNASVWDAKVVSFSENKFLTASADKTIKLWQ-NDKVIKTFSGIHNDVV 182

  Fly   197 RGVMGLDANTLLSCGNDAVLRFWN-EDGECVREMNGHSNYIYSMARNEALGDQVVVSCGEDSTLR 260
            |.:..:|....:||.||.:::..: ..|:.:|...||.:::|.:   :.|.:..:||||||.|:|
Yeast   183 RHLAVVDDGHFISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCI---KLLPNGDIVSCGEDRTVR 244

  Fly   261 MWNVITGDELGAPIIHPGISVWSVTCLQNGDIVTGCSDGVVRVFSHVPARQASEAVLKAFDLVVA 325
            :|:...| .|...|..|.||:|||.|:.||||:.|.||.:||:||...:|.|||..:.  :|...
Yeast   245 IWSKENG-SLKQVITLPAISIWSVDCMSNGDIIVGSSDNLVRIFSQEKSRWASEDEIN--ELSTQ 306

  Fly   326 TRKSQINEEIGGVKKTDLPGPEALLSNGTREGQTKMVRHADGSVKCYTWTLGNWNLVGDVTGATG 390
            ..||.|:.:.....::.|...|.|.|.|.:|||..:|:...|:::.:.::..:|..||||.||  
Yeast   307 VEKSTISSKTIEFDESKLSPYEILQSPGRKEGQIVVVKSPQGTIEAHQFSNSSWKKVGDVVGA-- 369

  Fly   391 GTQSNSGKKLHEGKEYDFVFSVDISDTEPPIKLPYNRSDDPWQAAQTFIHRHSLPQAYLDQVANF 455
            |...|..|...|||.||:||.|||.|.:||:|||.|.||:|:.||..|:.|:.||.:|.|||..|
Yeast   370 GATGNDKKIEFEGKTYDYVFDVDIEDGKPPLKLPINVSDNPYTAADNFLARYELPMSYRDQVVQF 434

  Fly   456 IIKNSEGPVLMEQAPTGYQDPFTGGSRYVPGSSNTNMGSGGNVDPFTGASSYSTASSNAQSQVDV 520
            |:||:.| :.::|                   .|.|                  |||:|.|....
Yeast   435 ILKNTNG-ISLDQ-------------------PNDN------------------ASSSAVSPSKT 461

  Fly   521 NFVRSGDKHFPVSNYRIFDTCDAKKVLEKMIEFNG--KLSLPDGRVGEEVLLAV---IKLADQSP 580
            :.:    |..||..|.|.:..:...:      |||  |::..:....:|:|..:   :...|:|.
Yeast   462 SVM----KVLPVKQYLIMENYNPDTI------FNGIVKINSNEKTFDDEILAQIGGALHDIDESW 516

  Fly   581 ELDLTSLEALAILLKWPASMQFPVLDILRLAVR--------NEAIFSVLNNSHNFLATVIPQLSG 637
            ||.|:.  |..|...|  .::.|..||:||.|:        .:.|...|.|.:..|.        
Yeast   517 ELLLSF--ANTIRSNW--EIKTPAYDIVRLIVKKLPYSSDIKDYIEEGLGNKNITLT-------- 569

  Fly   638 SAPNQLMVVRCLANIMSH------AAGRQNVMSRLAEIID--LVGAIKTGSANLQIAVATFYLNL 694
                 ::.||.|.|..::      ......|...:.|.||  ...|....|.||.|||:|...|.
Yeast   570 -----MLTVRILVNCFNNENWGVKLLESNQVYKSIFETIDTEFSQASAKQSQNLAIAVSTLIFNY 629

  Fly   695 TISQTLDVAKSEVCHVVTSGI----VELLKWAKDLEACYRSMQAIGNLTTTSCGQETIAQVV-SV 754
            :...|...:..|:..:|...|    ..|.::.:..||.||...|.|||.|.   :.|:.|.. ||
Yeast   630 SALVTKGNSDLELLPIVADAINTKYGPLEEYQECEEAAYRLTVAYGNLATV---EPTLRQFANSV 691

  Fly   755 DYVMDKLRELTITPQDKN 772
            .::.:..|.....|:.|:
Yeast   692 TWLANIKRSYGNVPRFKD 709

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlapNP_524666.2 WD40 10..305 CDD:238121 99/301 (33%)
WD40 repeat 23..64 CDD:293791 9/40 (23%)
WD40 repeat 70..106 CDD:293791 8/38 (21%)
WD40 repeat 111..149 CDD:293791 16/37 (43%)
WD40 repeat 156..190 CDD:293791 7/34 (21%)
WD40 repeat 196..230 CDD:293791 9/34 (26%)
WD40 repeat 236..277 CDD:293791 14/40 (35%)
WD40 repeat 284..304 CDD:293791 11/19 (58%)
PFU 353..462 CDD:462670 50/108 (46%)
PUL 531..781 CDD:462428 66/268 (25%)
DOA1NP_012709.1 WD40 5..288 CDD:238121 99/301 (33%)
WD40 repeat 58..97 CDD:293791 8/38 (21%)
WD40 repeat 102..134 CDD:293791 16/37 (43%)
WD40 repeat 142..175 CDD:293791 6/33 (18%)
WD40 repeat 182..217 CDD:293791 9/34 (26%)
WD40 repeat 223..260 CDD:293791 14/40 (35%)
WD40 repeat 267..287 CDD:293791 11/19 (58%)
PFU 333..443 CDD:462670 51/112 (46%)
PUL 468..712 CDD:462428 66/268 (25%)

Return to query results.
Submit another query.