DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Plap and ufd-3

DIOPT Version :10

Sequence 1:NP_524666.2 Gene:Plap / 43978 FlyBaseID:FBgn0024314 Length:787 Species:Drosophila melanogaster
Sequence 2:NP_496146.1 Gene:ufd-3 / 3565222 WormBaseID:WBGene00007333 Length:860 Species:Caenorhabditis elegans


Alignment Length:881 Identity:235/881 - (26%)
Similarity:375/881 - (42%) Gaps:153/881 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SLDNYKLSCELLGHSMDVRAVAVGPPTPEGRQTILSGSRDKSTKVWKPHGNEYLESLTLQDHKNF 68
            |:..|.:|..:..|..|.:|:||   |..|  .::||.||::.|.|...|.:|.::...:..|..
 Worm    15 SMPQYTISHVIEAHKSDTKALAV---TQGG--CLISGGRDETVKFWAKKGKQYTKTHAFEQPKGI 74

  Fly    69 -ISYICFLE-SERW-ICTASNDATICIYKQDGFVPLLTLKGHESTVCALSAGLEPRSLISGSWDK 130
             ::.|.:.| ::.| :.....|.||.::......|......|:..||.|....:...::|||||.
 Worm    75 TVNSIAYAELADGWRLFVGRRDGTIAVFGPSQAEPYAIFNEHKQNVCCLHINEKATHMLSGSWDS 139

  Fly   131 TARVWTISEAGDVSF----VALEGHEAAVWAVATLKE-QRKYVTGGADRNIYYWNAKGEKLRLLK 190
            ...:|.|:|....||    :...||..:|||:|:..: ...|::..||:.|..|.. ...|.:.|
 Worm   140 NVIIWPITELNSSSFTFQTIVCPGHTLSVWALASFPDLPNTYLSASADKTIRMWFG-DTTLSVFK 203

  Fly   191 GHTDCVRGVMGLDANTLLSCGNDAVLRFWN-EDGECVREMNGHSN-YIYSMARNEALGDQVVVSC 253
            ||||.||.::.|.::..||.|||..:..|: .....:|:....:: :||||    .|.|..:::.
 Worm   204 GHTDVVRALVVLSSSHFLSAGNDGHIIHWDVASASILRKFATQAHEFIYSM----TLSDSHILTT 264

  Fly   254 GEDSTLRMWNVITGDELGAPIIH------PGISVWSVTCLQNGDIVTGCSDGVVRVFSHVPARQA 312
            |||.||..|.:..|.:....|:.      |..:.|....|.|.||....|||.:.:.:....|:|
 Worm   265 GEDGTLEFWAIDGGKDGNLAIVSEAVIQLPTTNTWDAKVLLNSDIAVAGSDGRIYIMTTDKNRKA 329

  Fly   313 SEAVLKAFD------LVVATRKSQINEEIGGVKKTDLPGPEALLS----NGTREGQTKMVRHADG 367
            .:.:|.|||      |...|.:.:..|......|.|:......|:    .||..|          
 Worm   330 DDDILDAFDAEVVAKLTAKTERMKQEEHETVTIKVDIDDRPTQLNLKYKKGTDPG---------- 384

  Fly   368 SVKCYTWTLGNWNL-----------VGDVTGATGGTQSNSGKK-LHEGKEYDFVFSVDISDTEPP 420
              .|....|...||           :.|...........|||| :.:|||||:...|:....||.
 Worm   385 --LCAQEFLSENNLPIHYLEEITRFIKDRIPEARAFDLKSGKKVIVDGKEYDYALGVNFGKGEPD 447

  Fly   421 IKLPYNRSDDPWQAAQTFIHRHSLPQAYLDQVANFII----KNSEGPVLMEQAPTGYQDPFTGGS 481
            .::|:|.::.|..|||.|:.||.||.:.:..:|..|.    |.|:|..   .|.:||:|||||..
 Worm   448 KQMPFNVNESPQFAAQRFVERHQLPVSVIPSLAGMISQEMDKLSKGAA---SAQSGYEDPFTGPG 509

  Fly   482 RYVP-GSSNTNMGSGGN-VDPFTGASSYSTASSNAQSQVDVNFVRSGD----------------- 527
            |||| ||||    |||: .|||||:..|...:||: |..|..|  |||                 
 Worm   510 RYVPQGSSN----SGGHGADPFTGSGRYVPQASNS-SGFDTGF--SGDPLTGDGGYRASAPENTG 567

  Fly   528 KH------------------FPVSNYRIFDTC-DAKKVLEKMIEFNGKLSL----PDGRVGEEVL 569
            .|                  .||.::.|.... ..:|.:.|:.|.|.|...    ||...|.|.|
 Worm   568 SHAVPLSSLPQNKKKPRGPLVPVPDFYIIGLAGKGEKAIAKLKELNEKQDAFQLNPDQINGLEEL 632

  Fly   570 LAVIKLADQSPELDLTSLEALAILLKWPASMQFPVLDILRLAVRNEAI---FSVLNNSHNFLATV 631
            ..:...::.|.|:..::.|   :.|:||.....||||.||:|:.:.::   |.........:..:
 Worm   633 FVLPTSSNYSSEVTQSAFE---MSLQWPVEHLTPVLDFLRIALTHHSLNSYFCDRERGQELVGRL 694

  Fly   632 IPQLSGSAPN---QLMVVRCLANIMSHAAGR----QNVMSRLAEIIDLVGAIKTGSANLQIAVAT 689
            |..|.....:   :::|.||:||..||..||    ...:|.||.::  |..:......||::.||
 Worm   695 IAILVSDPADVALKVLVCRCIANAFSHPVGRNLFASTELSTLAPLV--VRQVLNEKTVLQMSAAT 757

  Fly   690 FYLNLTISQTLDVAKSEVC----------HVVTSGI--VELLKWAKDLEACYRSMQAIGNLTTTS 742
            ...|.:::.   :.:||.|          ..:.:||  |:...:..: :|..|.:||   |.|..
 Worm   758 ALANWSLAL---LQQSEQCEQLGPKEDLLRAILNGIESVDSFGYLGE-DAIIRLLQA---LVTVM 815

  Fly   743 CGQETIAQVV---SVDYVMDKLRELTITPQDKNFSK 775
            .|..::.::.   ::..:..:|::.......||.::
 Worm   816 WGDASVIRLAKNRNIAQIAARLKDAVSNDSGKNIAR 851

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlapNP_524666.2 WD40 10..305 CDD:238121 88/310 (28%)
WD40 repeat 23..64 CDD:293791 13/40 (33%)
WD40 repeat 70..106 CDD:293791 7/37 (19%)
WD40 repeat 111..149 CDD:293791 13/41 (32%)
WD40 repeat 156..190 CDD:293791 9/34 (26%)
WD40 repeat 196..230 CDD:293791 10/34 (29%)
WD40 repeat 236..277 CDD:293791 14/46 (30%)
WD40 repeat 284..304 CDD:293791 7/19 (37%)
PFU 353..462 CDD:462670 35/124 (28%)
PUL 531..781 CDD:462428 63/275 (23%)
ufd-3NP_496146.1 WD40 22..320 CDD:475233 88/307 (29%)
WD40 repeat 77..115 CDD:293791 7/37 (19%)
WD40 repeat 120..162 CDD:293791 13/41 (32%)
WD40 repeat 170..202 CDD:293791 8/32 (25%)
WD40 repeat 209..246 CDD:293791 10/36 (28%)
WD40 repeat 251..287 CDD:293791 14/39 (36%)
WD40 repeat 294..320 CDD:293791 9/25 (36%)
PFU <363..408 CDD:462670 10/56 (18%)
PFU <422..474 CDD:462670 23/51 (45%)
PUL 599..839 CDD:462428 58/251 (23%)

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