DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Plap and plaa

DIOPT Version :10

Sequence 1:NP_524666.2 Gene:Plap / 43978 FlyBaseID:FBgn0024314 Length:787 Species:Drosophila melanogaster
Sequence 2:NP_997855.1 Gene:plaa / 324855 ZFINID:ZDB-GENE-030826-13 Length:798 Species:Danio rerio


Alignment Length:838 Identity:295/838 - (35%)
Similarity:446/838 - (53%) Gaps:116/838 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 DNYKLSCELLGHSMDVRAVAVGPPTPEGRQTILSGSRDKSTKVWKPHGNE---YLESLTLQDHKN 67
            ::|:|...|..|.||||.:| ....|:|  ..:|.|||::.:||.|:.:|   :.|...:..|.|
Zfish     5 NSYRLRSSLPAHDMDVRGLA-AVAFPDG--AFVSVSRDRTARVWVPNPSENQSFTEMHCMNGHSN 66

  Fly    68 FISYICFLE-SERW----ICTASNDATICIYKQDGFVPLLTLKGHESTVCALSAGLEPRSLISGS 127
            |:|.:|.:. :|.:    ..|..:|..||::..|...||.|||||::|||.|||| :..:::|||
Zfish    67 FVSCVCIISPNETYPRGLTATGGHDNNICVFSLDRPDPLFTLKGHKNTVCTLSAG-KFGTILSGS 130

  Fly   128 WDKTARVWTISEAGDVSFVALEGHEAAVWAVATLKEQRKYVTGGADRNIYYWNAKGEKLRLLKGH 192
            ||.||:||    .|:...:.|:||.||||||..|.||...::|.||:.|..|.| |...:...||
Zfish   131 WDTTAKVW----LGEKCMMTLQGHTAAVWAVLILPEQGLMLSGSADKTIKLWKA-GRCEKTYTGH 190

  Fly   193 TDCVRGVMGLDANTLLSCGNDAVLRFWNEDGECVREMNGHSNYIYSMARNEALGDQVVVSCGEDS 257
            .|.|||:..::.....||.|||.:|.|...||||:...||:|||||:|......|  .:|.|||.
Zfish   191 EDSVRGLAVINDVEFFSCSNDASIRRWMVTGECVQVYYGHTNYIYSIAVFPNGKD--FISTGEDR 253

  Fly   258 TLRMWNVITGDELGAPIIHPGISVWSVTCLQNGDIVTGCSDGVVRVFSHVPARQASEAVLKAFDL 322
            |||:|.   ..|....|..|..|||....|.||||..|.|||::|||:....|.||...|:||:.
Zfish   254 TLRVWK---EGECSQTIRLPAQSVWCCCILPNGDIAVGASDGIIRVFTESEDRVASAQDLQAFED 315

  Fly   323 VVATRKSQINE---EIGGVKKTDLPGPEALLSNGTREGQTKMVRHADGS-VKCYTWTL--GNWNL 381
            .::  |:.|:.   ::|.:|..:|||.|.|...|.|:|||::::  :|| |:.|.|::  |.|..
Zfish   316 ELS--KAVIDPKTGDLGDIKIEELPGREHLDEPGNRDGQTRLIK--EGSNVEAYQWSMSDGRWMK 376

  Fly   382 VGDVTGATGGTQSNSGKKLHEGKEYDFVFSVDISDTEPPIKLPYNRSDDPWQAAQTFIHRHSLPQ 446
            :|||.|  |.:|.:|.:.::|||||||||::|:::..||:|||||.:||||..|..|:.::.|..
Zfish   377 IGDVVG--GSSQQSSKRVMYEGKEYDFVFTIDVNEGGPPMKLPYNVTDDPWLVAHNFLQKNDLSP 439

  Fly   447 AYLDQVANFIIKNSEGPVLMEQAP-------------------TGYQ---DPFTGGSRYVPGSSN 489
            .:|||||||||:|::|..| ..||                   .|.|   |||||..||:|||.:
Zfish   440 MFLDQVANFIIENTKGHTL-GAAPASAADPFTGAGRYIPGSGGNGQQFGADPFTGAGRYIPGSGS 503

  Fly   490 TNMGSGGNVDPFTGASSYSTASSNAQSQVDVNFVRSGDKHFPVSNYRIFDTCDAKKVLEKMIEFN 554
            |.....|..|||||.|:||:.|. .:|..::        .||.::..:|:..:..::|.|:.|.|
Zfish   504 TGTAPSGGADPFTGGSAYSSPSL-PKSTTNI--------FFPNTDGVMFEQSNTAQILGKLRELN 559

  Fly   555 GKLSLP-DGRVGE---EVLLAVIKLADQSPELDLTSLEALAILLK---WPASMQFPVLDILRLAV 612
              .|.| |.::.:   :.|..::.|..:.|.|:..:.|.:.:|.:   ||..:.|||||||||||
Zfish   560 --TSAPADHKLSDAALDCLEKLLNLVTELPNLEQPTAEQITVLWRACHWPEDIVFPVLDILRLAV 622

  Fly   613 RNEAIFSVLNNSH------------NFLATVIPQLSGSAPNQLMVVRCLANIMSHAAGRQNVMSR 665
            |:..:     |:|            :.|..:.|:  |.|.||::.:|.|.|..:.:.||..::.:
Zfish   623 RHPEV-----NAHLCGGTEGASLCNHLLGLMSPE--GKAANQMLALRTLCNCFTASHGRALLLGQ 680

  Fly   666 LAEIIDLVGAIKT-GSANLQIAVATFYLNLT---ISQTLDVAKSEVCHVVTSGIVELLKWAKDLE 726
            ...::...|.::| .:.|:.:|:||..||..   ..|..::.....|..|.|..:|::   :|.|
Zfish   681 RDAVLSRAGDLRTVCNKNIHVALATLVLNYAGRLYGQPAEIEAKAQCLSVASTALEVV---QDKE 742

  Fly   727 ACYRSMQAIGNLTTTSCGQETIAQVVSVDYVMDKLRELTITPQDKNFSKVN---SVGQ 781
            |.:|.:.|:|   ||..|..|         ..|..|.|.:..|...:::|:   .||:
Zfish   743 AVFRLLVALG---TTVSGDST---------AKDLARSLGVNSQISKYARVSEPAKVGE 788

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlapNP_524666.2 WD40 10..305 CDD:238121 124/302 (41%)
WD40 repeat 23..64 CDD:293791 12/43 (28%)
WD40 repeat 70..106 CDD:293791 12/40 (30%)
WD40 repeat 111..149 CDD:293791 16/37 (43%)
WD40 repeat 156..190 CDD:293791 13/33 (39%)
WD40 repeat 196..230 CDD:293791 14/33 (42%)
WD40 repeat 236..277 CDD:293791 15/40 (38%)
WD40 repeat 284..304 CDD:293791 10/19 (53%)
PFU 353..462 CDD:462670 53/111 (48%)
PUL 531..781 CDD:462428 71/275 (26%)
plaaNP_997855.1 WD40 9..297 CDD:238121 123/301 (41%)
WD40 repeat 69..110 CDD:293791 12/40 (30%)
WD40 repeat 113..149 CDD:293791 18/40 (45%)
WD40 repeat 154..188 CDD:293791 14/34 (41%)
WD40 repeat 195..228 CDD:293791 13/32 (41%)
WD40 repeat 234..268 CDD:293791 14/38 (37%)
PFU 346..457 CDD:462670 54/114 (47%)
PUL 536..791 CDD:462428 72/277 (26%)

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