Protein Alignment Plap and Plaa

DIOPT Version :10

• Sequence 1: NP_524666.2
• Gene: Plap / 43978
• FlyBaseID: FBgn0024314
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_446318.3
• Gene: Plaa / 116645
• RGDID: 621245
• Length: 795
• Species: Rattus norvegicus
• Alignment Length: 803
• Identity: 304/803 - (37%)
• Similarity: 427/803 - (53%)
• Gaps: 86/803 - (10%)

  Fly     8 YKLSCELLGHSMDVRAV--AVGPPTPEGRQTILSGSRDKSTKVWKPH--GNEYLESLTLQDHKNF 68
            |:|||.|.||.:|||.:  .:.||     ...:|.|||::|::|.|.  ...:.|...:..|.||
  Rat     8 YRLSCSLPGHELDVRGLVCCLYPP-----GAFVSVSRDRTTRLWAPDSPNRGFTEMHCMSGHSNF 67

  Fly    69 ISYICFLES-----ERWICTASNDATICIYKQDGFVPLLTLKGHESTVCALSAGLEPRSLISGSW 128
            :|.:|.:.|     ...|.|..||..|||:..|..:||..||||:.|||:||:| :..:|:||||
  Rat    68 VSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKDTVCSLSSG-KFGTLLSGSW 131

  Fly   129 DKTARVWTISEAGDVSFVALEGHEAAVWAVATLKEQRKYVTGGADRNIYYWNAKGEKLRLLKGHT 193
            |.||:||    ..|...:.|:||.||||||..|.||...:||.||:.|..|.| |...|...||.
  Rat   132 DTTAKVW----LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTIKLWKA-GRCERTFSGHE 191

  Fly   194 DCVRGVMGLDANTLLSCGNDAVLRFWNEDGECVREMNGHSNYIYSMARNEALGDQVVVSCGEDST 258
            |||||:..|.....|||.|||.:|.|...|||:....||:|||||::......|  .|:..||.:
  Rat   192 DCVRGLAILSETEFLSCANDASIRRWQITGECLGVYYGHTNYIYSISVFPNCRD--FVTTAEDRS 254

  Fly   259 LRMWNVITGDELGAPIIHPGISVWSVTCLQNGDIVTGCSDGVVRVFSHVPARQASEAVLKAF--D 321
            ||:|.   ..|....|..|..|:|....|.|||||.|.|||::|||:....|.||...:|||  :
  Rat   255 LRIWK---HGECAQTIRLPAQSIWCCCVLDNGDIVVGASDGIIRVFTEADERTASAEEIKAFERE 316

  Fly   322 LVVATRKSQINEEIGGVKKTDLPGPEALLSNGTREGQTKMVRHADGS-VKCYTWTL--GNWNLVG 383
            |..||..|:.. ::|.:....|||.|.|...|||||||:::|  ||. |:.|.|::  |.|..:|
  Rat   317 LSQATIDSKTG-DLGDINAEQLPGREHLNEPGTREGQTRLIR--DGERVEAYQWSVSDGRWIKIG 378

  Fly   384 DVTGATGGTQSNSGKKLHEGKEYDFVFSVDISDTEPPIKLPYNRSDDPWQAAQTFIHRHSLPQAY 448
            ||.|::|..|..|||.|:||||:|:|||:|:::..|..|||||.|||||..|..|:.::.|...:
  Rat   379 DVVGSSGANQQTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNVSDDPWLVAYNFLQKNDLNPMF 443

  Fly   449 LDQVANFIIKNSEGPVLMEQAPTGYQDPFTGGSRYVPGS---SNTNM-------------GSGG- 496
            |||||.|||.|::|..| ....|.:.||||||.|||||:   |||..             ||.|
  Rat   444 LDQVAKFIIDNTKGQTL-GLGNTSFSDPFTGGGRYVPGTSGPSNTVQTADPFTGAGRYMPGSAGM 507

  Fly   497 -----NVDPFTGASSYSTASSNAQSQVDVNFVRSGDKHFPVSNYRIFDTCDAKKVLEKMIEFNG- 555
                 .||||||.|:|.:|:|..     ||.      :||......||..:..::|.|:.|.||
  Rat   508 DTTMAGVDPFTGNSAYRSAASKT-----VNI------YFPKKEALTFDQANPTQILGKLKELNGS 561

  Fly   556 -----KLSLPDGRVGEEVLLAVIKLADQSPELDLTSLEALAILLKWPASMQFPVLDILRLAVRNE 615
                 ||:..|..:.|::|..:...|.:.|...  .|:.|...:.||..:.||.||||||::::.
  Rat   562 APEEKKLTEDDLVLLEKILSLICGNASEKPTAQ--QLQVLWKAINWPEDIVFPALDILRLSIKHP 624

  Fly   616 AI---FSVLNNSHNFLATVIPQLS--GSAPNQLMVVRCLANIMSHAAGRQNVMSRLAEIIDLVGA 675
            ::   |........|.:.:|..|:  |...|||:.:|...|.....||::.:||:...::.....
  Rat   625 SVNENFCNEKEGDQFSSHLINLLNPKGKPANQLLALRTFCNCFVSQAGQKLMMSQRESLMSHAIE 689

  Fly   676 IKTGS-ANLQIAVATFYLNLTISQTLD--VAKSEVCHVVTSGIVELLKWAKDLEACYRSMQAIGN 737
            :|:|| .|:.||:||..||.::....|  :.....|..|.|.|:|::   :||||.:|.:.|:|.
  Rat   690 LKSGSNKNIHIALATLTLNYSVCFHKDHNIEGKAQCLSVISTILEVV---QDLEATFRLLVALGT 751

  Fly   738 LTTTSCGQETIAQVVSVDYVMDK 760
            |.:.......:|:.:.||..:.|
  Rat   752 LISDDSNAIQLAKSLGVDSQIKK 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plap	NP_524666.2	WD40	10..305	CDD:238121	127/303 (42%)
		WD40 repeat	23..64	CDD:293791	10/44 (23%)
		WD40 repeat	70..106	CDD:293791	14/40 (35%)
		WD40 repeat	111..149	CDD:293791	16/37 (43%)
		WD40 repeat	156..190	CDD:293791	15/33 (45%)
		WD40 repeat	196..230	CDD:293791	15/33 (45%)
		WD40 repeat	236..277	CDD:293791	12/40 (30%)
		WD40 repeat	284..304	CDD:293791	11/19 (58%)
		PFU	353..462	CDD:462670	57/111 (51%)
		PUL	531..781	CDD:462428	69/244 (28%)
Plaa	NP_446318.3	WD40	10..297	CDD:238121	126/302 (42%)
		WD 1	17..56		13/43 (30%)
		WD 2	63..107		16/43 (37%)
		WD40 repeat	69..110	CDD:293791	14/40 (35%)
		WD 3	110..148		19/42 (45%)
		WD40 repeat	115..148	CDD:293791	16/37 (43%)
		WD 4	149..188		20/39 (51%)
		WD40 repeat	155..188	CDD:293791	15/33 (45%)
		WD 5	190..227		18/36 (50%)
		WD40 repeat	194..228	CDD:293791	15/33 (45%)
		WD 6	229..268		15/43 (35%)
		WD40 repeat	234..268	CDD:293791	11/38 (29%)
		WD 7	270..307		18/36 (50%)
		WD40 repeat	274..297	CDD:293791	12/22 (55%)
		PFU	346..459	CDD:462670	58/114 (51%)
		PUL	536..789	CDD:462428	69/244 (28%)
		ARM 1	546..588		10/41 (24%)
		ARM 2	589..620		12/32 (38%)
		ARM 3	621..669		10/47 (21%)
		ARM 4	670..715		14/44 (32%)
		ARM 5	716..755		14/41 (34%)
		ARM 6	756..795		4/19 (21%)