Protein Alignment wb and NetB

DIOPT Version :10

• Sequence 1: NP_723870.1
• Gene: wb / 43946
• FlyBaseID: FBgn0261563
• Length: 3375
• Species: Drosophila melanogaster
• Sequence 2: NP_511155.1
• Gene: NetB / 32400
• FlyBaseID: FBgn0015774
• Length: 793
• Species: Drosophila melanogaster
• Alignment Length: 595
• Identity: 130/595 - (21%)
• Similarity: 195/595 - (32%)
• Gaps: 202/595 - (33%)

  Fly   132 GGGALRLLKTEDVYSSSFSGGLYPPLFNVVPRAQISVNATCGQNGAEEYCKQVGAKPCGICNAHS 196
            |..|..:...:..|.........|...|......:..::.||....|.||:.:.....|.|.:..
  Fly    22 GSSAAGISSNDPCYFEGKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYCELLRDGNAGECRSCE 86

  Fly   197 SDRAKQRSIQSLISSGSGSGSGSGFEEGWWQS-----PTLQGGRQFEYVTILLDLKQTFQIFSVW 256
            ..|....::..|.:..:.:         .|:|     |........:.||:.|.|.:.:::..:.
  Fly    87 QQRYGPAALTDLNNPSNVT---------CWRSGAVNVPHDPDSAPPDNVTLTLSLGKKYELTYIS 142

  Fly   257 LK-SANSPRPASWILEKSLD-GINFEPWQYFGLSDADCQRRWNLSGQNGKYVFQNDTEIIC-STQ 318
            |. ...||||.|..:.||.| |..::|:|::   .:.||:.:. .....|....|:.|..| ::|
  Fly   143 LSFCPRSPRPDSLAIFKSSDFGQTWQPFQFY---SSQCQKFYG-RPDRAKISKFNEQEARCINSQ 203

  Fly   319 FSKPGPLENGVLHASLLKNRPGAT--DQSPELMKFITTRYIRIRLQGMH--------STAN---- 369
            ....|..:....:.  |:.||.|.  |.|..|..::|...||:....:.        ..||
  Fly   204 HDTGGAAQRFAFNT--LEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAFSD 266

  Fly   370 -----------------------------QDNS------------------------LDWLLDSP 381
                                         |||.                        ||:..|..
  Fly   267 EMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGE 331

  Fly   382 SL------------EKH-------------------------------------------SFYSL 391
            |:            |||                                           ..|::
  Fly   332 SVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHYAV 396

  Fly   392 SQLKVSARLDCNGHAN--------------------RSHESPDDP----------------LMQC 420
            |...|..|..|||||:                    :..::|..|                .|.|
  Fly   397 SDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMTC 461

  Fly   421 ICQHNTCGAQCEQCCPLFQDRPY-----QMGGECEICQCYGHAESCTYDPFLDK-------GICQ 473
            .|:|||.|.:||:|.|.:.|||:     ....||::|||.|||..|.::..|.|       |:|.
  Fly   462 ACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLELYKLSGRVSGGVCY 526

  Fly   474 SCSNNTAGIECEFCEMGFYRELDAPLTDP-----CLPCSCNPARSTG-GCQSDGGSCNCLEGFQG 532
            :|.::|.|..|.:|..|:||:...|   |     |..|.|:|..||| .|....|.|.|.||..|
  Fly   527 NCQHDTTGRYCHYCREGYYRDATKP---PNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTG 588

  Fly   533 KNCEECAPGY 542
            ..|..||.||
  Fly   589 LTCNRCARGY 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	153..398	CDD:459653	63/374 (17%)
		EGF_Lam	401..450	CDD:238012	22/89 (25%)
		EGF_Lam	505..552	CDD:238012	18/39 (46%)
		Laminin_EGF	550..597	CDD:395007
		Laminin_B	660..813	CDD:459652
		EGF_Lam	851..900	CDD:238012
		Laminin_EGF	<943..971	CDD:395007
		Laminin_EGF	974..1018	CDD:395007
		EGF_Lam	1017..1065	CDD:238012
		Laminin_EGF	1065..>1105	CDD:395007
		EGF_Lam	1150..1197	CDD:238012
		Laminin_EGF	1199..1247	CDD:395007
		EGF_Lam	1247..1292	CDD:238012
		Laminin_EGF	1294..1342	CDD:395007
		Laminin_EGF	1340..1392	CDD:395007
		Laminin_B	1486..1626	CDD:459652
		EGF_Lam	1669..1716	CDD:238012
		Laminin_EGF	1718..1767	CDD:395007
		EGF_Lam	1772..1819	CDD:238012
		YhaN	<1907..2141	CDD:443752
		SMC_prok_B	<2123..>2390	CDD:274008
		Laminin_II	2279..2400	CDD:368703
		LamG	2399..>2492	CDD:473984
		LamG	2586..2753	CDD:238058
		Laminin_G_2	2804..2944	CDD:460494
		LamG	3018..3167	CDD:238058
		LamG	3192..3347	CDD:238058
NetB	NP_511155.1	LamNT	37..261	CDD:214532	48/238 (20%)
		EGF_Lam	<458..484	CDD:238012	13/25 (52%)
		EGF_Lam	498..555	CDD:238012	21/59 (36%)
		EGF_Lam	560..608	CDD:238012	18/39 (46%)
		NTR_netrin-1_like	661..791	CDD:239634