DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sbr and ssp2

DIOPT Version :9

Sequence 1:	NP_524660.1	Gene:	sbr / 43944	FlyBaseID:	FBgn0003321	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_001287065.1	Gene:	ssp2 / 39540	FlyBaseID:	FBgn0036389	Length:	982	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	104/511 - (20%)
Similarity:	180/511 - (35%)	Gaps:	140/511 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 NGHLPDGYRLMPRVRSGIPLVAIDDAFKEKMKVTMAKRYN------IQTKALDLSRFHADPD--L 229
            |.:...||....:.|..:.|..|..|..:|...|...|.|      .:|...:..:|..|..  |
  Fly   367 NNNNKAGYTPTLKGRGDMNLSPIVGATPQKPTGTAPGRLNNTFEPVAKTAPFNGEKFVLDTMELL 431

  Fly   230 KQVFCPL---FRQNVMGAAIDIMCDNIPDLEALNLNDNSISSMEAFKGVEKRLPNLKILYLGDNK 291
            :|:..||   :...:......:.|  :.||....:      .|.|.:|.|::..|:
  Fly   432 EQIEQPLDGTYNLQMSEQHRQMQC--VMDLAEAEV------EMLAQQGDEEQFENM--------- 479

  Fly   292 IPSLAHLVVLRNLSILELVLKNNPCRSRYKDSQQFISEVRRKFPKLVKLDGETLEPQITFDLSEQ 356
               ||.|..:..|:..:|.:            |:.:..::|:|.: .:.:.|..|.::....:|:
  Fly   480 ---LAELGKVNTLNEEQLKM------------QKSLDTIKRRFHR-DEAEAEEREEELQQSAAEK 528

  Fly   357 ---GRLLETKASYLCDVAGAEVVRQFLDQYFRIFDSGNRQALLDAYHEKAMLSISMPSASQAGRL 418
               ..|.::.:|......|.|   :.|.:..|::|..|    |.|.|.....|.|..||
  Fly   529 VDTPVLNQSHSSSNSSGGGGE---RLLSRRSRLYDDVN----LSAMHGSNGSSTSTNSA------ 580

  Fly   419 NSFWKFNRNLRRLLNGEENRTRNLKYGRLACVSTLDEWPKTQ-----------------HDRRTF 466
             ||....|::.::.....:..          ....:|.||:|                 .||..|
  Fly   581 -SFIVQRRDMPQVEQPAPDPD----------PEPAEEPPKSQVTAEIDPASYKLPERRERDRDRF 634

  Fly   467 TVDLTIYNTSMMVFTVTGLFKELNDETNNPASME------LYDVRHFARTYVVVPQNNG-----F 520
            .   ||..:..|......:...::||   |..:|      :.|||:      ...|..|     .
  Fly   635 K---TIKISKEMRLQPEIIVPCIDDE---PQQLEDEQKQLVEDVRY------EEDQRQGSPPGRL 687

  Fly   521 CIRNETIFITN---------ATHEQVRE----FKRSQHQPAP-GAMPSTSSAVTSPQAGA----A 567
            ..|::|..|:|         .|:::.:|    .:|.|.|.|| .|.|:.:|.:..|::.:    .
  Fly   688 SRRDQTTAISNNADASASNYLTYKKPKEKSLIQRRPQQQEAPLLAEPAPASTLPQPRSLSRPRYI 752

  Fly   568 AGLQGRLNALGVATGPVAILSGDPLAATAPVNSGSAAISTTAVAPGAQDESTKMQM 623
            :||| :...:..||...|.|:..|          :||:.||...|...:...|..|
  Fly   753 SGLQ-KFTTVSKATSAGAGLNATP----------AAAMPTTVTVPANGNGELKSPM 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbr	NP_524660.1	Tap-RNA_bind	112..191	CDD:286271	4/17 (24%)
		leucine-rich repeat	215..255	CDD:275382	8/44 (18%)
		LRR_RI	<223..341	CDD:238064	22/122 (18%)
		LRR_8	256..315	CDD:290566	11/58 (19%)
		LRR_4	256..298	CDD:289563	8/41 (20%)
		leucine-rich repeat	256..281	CDD:275382	5/24 (21%)
		leucine-rich repeat	282..305	CDD:275382	3/22 (14%)
		leucine-rich repeat	306..336	CDD:275382	4/29 (14%)
		NTF2	372..531	CDD:238403	38/186 (20%)
		Big_3_5	<578..>614	CDD:293246	10/35 (29%)
		TAP_C	609..671	CDD:197882	3/15 (20%)
ssp2	NP_001287065.1	PHA03247	<676..965	CDD:223021	32/133 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3763
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900