DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and CHRNA6

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_004189.1	Gene:	CHRNA6 / 8973	HGNCID:	15963	Length:	494	Species:	Homo sapiens

Alignment Length:	368	Identity:	79/368 - (21%)
Similarity:	147/368 - (39%)	Gaps:	44/368 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 WFYDCGFDGYGSEIAPIVKEETKTEKLLSHLN---IQAENASMPANLSSISFHFQ---TRSLAYE 251
            |.  |.|..:.........||....||.||.|   ...||.|.|     ::.||:   |:....:
Human    17 WL--CVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDP-----VTVHFEVAITQLANVD 74

  Fly   252 QTSSLLQTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYEL 316
            :.:.:::|.:.:...|.|.:|.|.|.::..:|:...|..:||||.:.:.|.|:... ||....:.
Human    75 EVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDF-QVEGKTKA 138

  Fly   317 MVYANGSITLYAQNLQLASWCVDSARNWPSERVTCDIELGLNGQEGQENVALIYDDQRKPIAPNE 381
            ::..||.|| :.......|.|......:|.:...|.::.|....:..|...||...:
Human   139 LLKYNGMIT-WTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSK-------- 194

  Fly   382 HVNTPSGWSFTQMSVVLVENDSQR-----RYNPKGMMQKMTGDVAIEFTLQRNRSFYMTVFYLPL 441
             |:....|..::..::    |:..     :||   ..:::..|:...|.::|...||.....:|.
Human   195 -VDMNDFWENSEWEII----DASGYKHDIKYN---CCEEIYTDITYSFYIRRLPMFYTINLIIPC 251

  Fly   442 IACQMFLILSFVLRST--RRSSLILIALLIAAWGLMYMTR-YASPHYVPPMMTAYKVIMMTTTYC 503
            :......:|.|.|.|.  .:.:|.:..||.....|:.:|. ..|...|.|::..|.:..|.....
Human   252 LFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTL 316

  Fly   504 YILHICIIWLDLY---PPRSKAPGWLVRVINSNVLRCILGLRF 543
            .|: :.:..|:::   |.....|.| |:.:...:|..:|.:|:
Human   317 SIV-VTVFVLNIHYRTPTTHTMPRW-VKTVFLKLLPQVLLMRW 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	49/227 (22%)
CHRNA6	NP_004189.1	Neur_chan_LBD	34..484	CDD:332142	76/349 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810