Protein Alignment NtR and CHRNA6

DIOPT Version :10

• Sequence 1: NP_651958.2
• Gene: NtR / 43935
• FlyBaseID: FBgn0029147
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_004189.1
• Gene: CHRNA6 / 8973
• HGNCID: 15963
• Length: 494
• Species: Homo sapiens
• Alignment Length: 368
• Identity: 79/368 - (21%)
• Similarity: 147/368 - (39%)
• Gaps: 44/368 - (11%)

  Fly   193 WFYDCGFDGYGSEIAPIVKEETKTEKLLSHLN---IQAENASMPANLSSISFHFQ---TRSLAYE 251
            |.  |.|..:.........||....||.||.|   ...||.|.|     ::.||:   |:....:
Human    17 WL--CVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDP-----VTVHFEVAITQLANVD 74

  Fly   252 QTSSLLQTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYEL 316
            :.:.:::|.:.:...|.|.:|.|.|.::..:|:...|..:||||.:.:.|.|:... ||....:.
Human    75 EVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDF-QVEGKTKA 138

  Fly   317 MVYANGSITLYAQNLQLASWCVDSARNWPSERVTCDIELGLNGQEGQENVALIYDDQRKPIAPNE 381
            ::..||.|| :.......|.|......:|.:...|.::.|....:..|...||...:
Human   139 LLKYNGMIT-WTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSK-------- 194

  Fly   382 HVNTPSGWSFTQMSVVLVENDSQR-----RYNPKGMMQKMTGDVAIEFTLQRNRSFYMTVFYLPL 441
             |:....|..::..::    |:..     :||   ..:::..|:...|.::|...||.....:|.
Human   195 -VDMNDFWENSEWEII----DASGYKHDIKYN---CCEEIYTDITYSFYIRRLPMFYTINLIIPC 251

  Fly   442 IACQMFLILSFVLRST--RRSSLILIALLIAAWGLMYMTR-YASPHYVPPMMTAYKVIMMTTTYC 503
            :......:|.|.|.|.  .:.:|.:..||.....|:.:|. ..|...|.|::..|.:..|.....
Human   252 LFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTL 316

  Fly   504 YILHICIIWLDLY---PPRSKAPGWLVRVINSNVLRCILGLRF 543
            .|: :.:..|:::   |.....|.| |:.:...:|..:|.:|:
Human   317 SIV-VTVFVLNIHYRTPTTHTMPRW-VKTVFLKLLPQVLLMRW 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	89..191	CDD:463505
		Neur_chan_LBD	212..429	CDD:460752	49/227 (22%)
CHRNA6	NP_004189.1	LIC	34..484	CDD:455710	76/349 (22%)
		LGIC_ECD	34..240	CDD:475126	50/228 (22%)