DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NtR and chrna4b

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001041528.1	Gene:	chrna4b / 556619	ZFINID:	ZDB-GENE-090505-3	Length:	627	Species:	Danio rerio

Alignment Length:	324	Identity:	70/324 - (21%)
Similarity:	132/324 - (40%)	Gaps:	31/324 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 EKLLSHLNIQAENASMP-ANLSSISF-HFQ---TRSLAYEQTSSLLQTRMHMMMHWRDSRLVWKP 276
            |:||..|.|.....|.| ||:|.:.. ||.   .:.:..::.:.::.|.:.:...|.|.:|.|.|
Zfish    32 ERLLQSLFINYNKLSRPVANISDVVLVHFGLSIAQLIDVDEKNQMMTTNVWVKQEWNDYKLRWNP 96

  Fly   277 EDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYELMVYANGSITLYAQNLQLASWCVDSA 341
            |::.::.|...|...||:|.:.:.|.|..... |....:..|:.||.|......:..:|..:| .
Zfish    97 EEYENVTSIRIPSEIIWRPDIVLYNNADGDFA-VTHLTKAQVFYNGRIKWKPPAIYKSSCSID-V 159

  Fly   342 RNWPSERVTCDIELGLNGQEGQENVALIYDDQR-KPIAPNEHVNTPSGWSFTQMSVVLVENDSQR 405
            ..:|.::..|.::.|          :..||..: ..|:....|:....|...:..::    ::..
Zfish   160 TFFPFDQQNCKMKFG----------SWTYDRAKIDLISMASDVDQMDYWESGEWVII----NAVG 210

  Fly   406 RYNPK--GMMQKMTGDVAIEFTLQRNRSFYMTVFYLP--LIACQMFLILSFVLRSTRRSSLILIA 466
            .||.|  ....::..|:...|.::|...||.....:|  ||:|...|:.........:.:|.:..
Zfish   211 TYNIKKYECCTEIYPDITYSFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECAEKITLCISV 275

  Fly   467 LLIAAWGLMYMTR-YASPHYVPPMMTAYKVIMMTTTYCYILHICIIWLDLYPPRSKA---PGWL 526
            ||.....|:.:|. ..|...|.|::..|.:..|......|: |.:..|:::...|:.   |.|:
Zfish   276 LLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSII-ITVFVLNVHHRSSRTHSMPHWV 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	46/219 (21%)
chrna4b	NP_001041528.1	Neur_chan_LBD	31..237	CDD:280998	47/220 (21%)
chrna4b	NP_001041528.1	Neur_chan_memb	244..618	CDD:280999	21/96 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810