Protein Alignment NtR and chrna5

DIOPT Version :10

• Sequence 1: NP_651958.2
• Gene: NtR / 43935
• FlyBaseID: FBgn0029147
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_001017885.1
• Gene: chrna5 / 550584
• ZFINID: ZDB-GENE-050417-440
• Length: 466
• Species: Danio rerio
• Alignment Length: 513
• Identity: 94/513 - (18%)
• Similarity: 171/513 - (33%)
• Gaps: 163/513 - (31%)

  Fly   175 PLVINYLSFSSFGSNTARWFYDCGFDGYGSEIAPIVKEETKTE-KLLSHLNIQAENASMPANLSS 238
            |||.:.:..|:.|                   .|::....||| ||..||....:....|  :..
Zfish    13 PLVCSAVLCSAIG-------------------PPMLSSYAKTEDKLFKHLFSNYQKWVRP--IED 56

  Fly   239 ISFHFQTR-SLAYEQ------TSSLLQTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPH 296
            ::...|.: .||..|      .:.|:.|.:.|...|.|.:|.|.|:.:..:.|...|...||.|.
Zfish    57 LNTTIQVKFGLAISQLVDVDEKNQLMTTNVWMKQEWTDLKLRWDPDHYLGITSIRVPSDSIWIPD 121

  Fly   297 MNVLNGALQSMGQVLQSYELMVYANGSITLYAQNLQLASWCVDSARNWPSERVTCDIELGLNGQE 361
            :.:.:.|..:....:.  :.:|..:|:|: :.......|.|......:|.:...|.::.|
Zfish   122 IVLYDNADGNFEATVT--KAVVRFDGTIS-WTPPANYKSACTIDVTFFPFDLQNCSMKFG----- 178

  Fly   362 GQENVALIYDDQRKPIAPNEHVNTPSGWSF--TQMSVVLVE-NDSQRRYNPKGMMQ--KMTGD-- 419
                                      .|::  :|:.::|.: :..:|.|...|..:  |.||:
Zfish   179 --------------------------SWTYDGSQVDILLEDVHVDKRDYFDNGEWEIVKATGNRG 217

  Fly   420 -----------VAIEFTLQRNRSFYMTVFYLPLIACQMFLILSFVLRST--RRSSL---ILIALL 468
                       :...|.::|...||.....:|.|......:|.|.|.|.  .:.||   :|::|.
Zfish   218 LRRDGTFFYPSITYSFIIRRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNGGEKISLCTSVLVSLT 282

  Fly   469 IAAWGLMYMTRYASPHYVPPMMTAYKVIMMTTTYCYILHICIIWLDLY-----PPRSKAPGWLVR 528
            :  :.|:......|...|.|::..|.|..|......|: |.:..::::     ...|.|| |:.|
Zfish   283 V--FLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIV-ITVFAINIHHRSSSTHHSMAP-WVRR 343

  Fly   529 VINSNVLRCI---------------------LGLRFSDSTDYCDIQEN----------------- 555
            :...::.|.:                     .|...|..|:..|.:.|
Zfish   344 IFLHHLPRLLCMRSHVDRYATSAGTRTGGLGYGKSLSQDTNQLDAEHNLQAALESIRYITRHVVK 408

  Fly   556 ---------PWHHMAKILNN-----------LSSILV----------IITFAIVDITS 583
                     .|..:|::|:.           |.|.|:          ||..:..:|||
Zfish   409 ENEVREVVQDWKFVAQVLDRVFLWAFLLVSLLGSALLFIPVIYKWASIIVPSYAEITS 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	89..191	CDD:463505	5/15 (33%)
		Neur_chan_LBD	212..429	CDD:460752	44/242 (18%)
chrna5	NP_001017885.1	LIC	12..448	CDD:455710	89/493 (18%)
		LGIC_ECD_nAChR_A5	34..240	CDD:349819	45/241 (19%)
		Cys-loop	159..173	CDD:349819	2/13 (15%)