Protein Alignment NtR and Chrne

DIOPT Version :10

• Sequence 1: NP_651958.2
• Gene: NtR / 43935
• FlyBaseID: FBgn0029147
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: XP_017452660.1
• Gene: Chrne / 29422
• RGDID: 2353
• Length: 547
• Species: Rattus norvegicus
• Alignment Length: 380
• Identity: 82/380 - (21%)
• Similarity: 149/380 - (39%)
• Gaps: 64/380 - (16%)

  Fly   185 SFGSNTARWFYDCGFDGYGSEIAPIVK-EETKTEKLLSHLNIQAENASMPANLSSISFHFQTRSL 248
            |.|.|.....|...||.|..|..|:.: |:|.|..|...|          .||.|::
  Rat    71 SQGKNEELSLYHHLFDNYDPECRPVRRPEDTVTITLKVTL----------TNLISLN-------- 117

  Fly   249 AYEQTSSLLQTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQS 313
               :....|.|.:.:.:.|:|.||.:..:||..:|....|...:|.|.: ||...:.....|...
  Rat   118 ---EKEETLTTSVWIGIEWQDYRLNFSKDDFAGVEILRVPSEHVWLPEI-VLENNIDGQFGVAYD 178

  Fly   314 YELMVYANGSIT-----LYAQNLQLASWCVDSARNWPSERVTCDIELGLNGQEGQENVALIY--D 371
            ..::||..||::     :|      .|.|......:|.:...|.: :..:.....|.|..|:  |
  Rat   179 CNVLVYEGGSVSWLPPAIY------RSTCAVEVTYFPFDWQNCSL-IFRSQTYNAEEVEFIFAVD 236

  Fly   372 DQRKPIAPNEHVNTPSGWSFTQMSVVLVENDSQRRYNPKGMMQKMTG---------DVAIEFTLQ 427
            |....|...: ::|.   :||:.....::      |.| ||::...|         ||.....::
  Rat   237 DDGNAINKID-IDTA---AFTENGEWAID------YCP-GMIRHYEGGSTEDPGETDVIYTLIIR 290

  Fly   428 RNRSFYMTVFYLPLIACQMFLILSFVL--RSTRRSSLILIALLIAAWGLMYMTRYASPH--YVPP 488
            |...||:....:|.:.....::|::.|  ::..:...:.|.:|:|....:::.....|.  ...|
  Rat   291 RKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVP 355

  Fly   489 MMTAYKVIMMTTTYCYILHICIIWLD--LYPPRSKAPGWLVRVINSNVLRCILGL 541
            ::..|.:.:|......::: |:|.|:  |..|.:.|....:|.|...:|..:|||
  Rat   356 LLGRYLIFVMVVATLIVMN-CVIVLNVSLRTPTTHATSPRLRQILLELLPRLLGL 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	89..191	CDD:463505	3/5 (60%)
		Neur_chan_LBD	212..429	CDD:460752	48/232 (21%)
Chrne	XP_017452660.1	LGIC_ECD_nAChR_E	102..292	CDD:349831	46/229 (20%)
		Cys-loop	201..215	CDD:349831	2/13 (15%)
		Neur_chan_memb	300..528	CDD:460753	22/111 (20%)