DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and HTR3E

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001243543.1	Gene:	HTR3E / 285242	HGNCID:	24005	Length:	482	Species:	Homo sapiens

Alignment Length:	380	Identity:	62/380 - (16%)
Similarity:	112/380 - (29%)	Gaps:	144/380 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 NASMPANLSSISFHFQTRSLAYEQTSSLLQTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIW 293
            |.|:|..: :|||          ..|::|.      :.|.:..:.|.||:...:.........:|
Human    74 NISVPTQV-NISF----------AMSAILD------VVWDNPFISWNPEECEGITKMSMAAKNLW 121

  Fly   294 KPHMNVLN------------------------GALQSMGQVLQSYELMVYANGSITLYAQNLQLA 334
            .|.:.::.                        |.|..:.:..:.....|...|.|. |.:.:::.
Human   122 LPDIFIIELCVSRAGQREVPSPGSHRDHSLPLGPLMDVDKTPKGLTAYVSNEGRIR-YKKPMKVD 185

  Fly   335 SWCVDSARNWPSERVTCDIELGLNGQEGQENVALIYD------DQRKPIAPNEHVNTPSGWSFTQ 393
            |.|......:|.::..|.:...          :.:|.      |..|.:           |..|.
Human   186 SICNLDIFYFPFDQQNCTLTFS----------SFLYTVDSMLLDMEKEV-----------WEITD 229

  Fly   394 MSVVLVENDSQRRYNPKGMMQKMTGDVAIEFTLQRNRSFY-MTVFYLPLIACQMFLILSFVLRST 457
            .|..:::...:         .::.|.......|.|..:.| ..|||:.:               .
Human   230 ASRNILQTHGE---------WELLGLSKATAKLSRGGNLYDQIVFYVAI---------------R 270

  Fly   458 RRSSLILIAL------LIAAWGLMYMTRYASPHYVP---PMMTAYKVIMM--------------- 498
            ||.||.:|.|      |:|...|.:.....|.:.||   .::..|.|.::
Human   271 RRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSGTPLIG 335

  Fly   499 ----------------TTTYCYILHICIIWLDLYPPRSKAPGWLVRVINSNVLRC 537
                            |....::||:.    ...||  ..|.||    :|.:|.|
Human   336 VYFALCLSLMVGSLLETIFITHLLHVA----TTQPP--PLPRWL----HSLLLHC 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	32/229 (14%)
HTR3E	NP_001243543.1	Neur_chan_LBD	70..273	CDD:280998	38/261 (15%)
HTR3E	NP_001243543.1	Neur_chan_memb	280..>379	CDD:280999	18/108 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900