DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and Chrna5

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_058774.2	Gene:	Chrna5 / 25102	RGDID:	2347	Length:	467	Species:	Rattus norvegicus

Alignment Length:	406	Identity:	70/406 - (17%)
Similarity:	141/406 - (34%)	Gaps:	128/406 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 EQTSSLLQTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVL---NGALQSMGQVLQ 312
            ::.:.|:.|.:.:...|.|.:|.|.|:|:|.::....|...:|.|.:.:.   :|..:.     .
  Rat    87 DEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKIIRVPSDSLWIPDIVLFDNADGRFEG-----A 146

  Fly   313 SYELMVYANGSITLYAQNLQLASWCVDSARNWPSERVTCDIELGLNGQEGQENVALIYDDQRKPI 377
            |.:.:|..||::| :.|.....|.|......:|.:...|.::.|
  Rat   147 STKTVVRYNGTVT-WTQPANYKSSCTIDVTFFPFDLQNCSMKFG--------------------- 189

  Fly   378 APNEHVNTPSGWSF--TQMSVVLVENDSQRR-YNPKGMMQKMT-----GD----------VAIEF 424
                      .|::  :|:.::|.:.|..|. :...|..:.|:     |:          :...|
  Rat   190 ----------SWTYDGSQVDIILEDQDVDRTDFFDNGEWEIMSAMGSKGNRTDSCCWYPYITYSF 244

  Fly   425 TLQRNRSFYMTVFYLPLIACQMFLILSFVLRSTRRSSL-----ILIALLIAAWGLMYMTRYASPH 484
            .::|...||.....:|.|......::.|.|.|.....:     :|::|.:  :.|:......|..
  Rat   245 VIKRLPLFYTLFLIIPCIGLSFLTVVVFYLPSNEGEKISLCTSVLVSLTV--FLLVIEEIIPSSS 307

  Fly   485 YVPPMMTAYKVI--------MMTTTYCYILH-------------ICIIWLDLYPP----RSKAPG 524
            .|.|::..|.|.        :|.|.:...:|             :..|:|...|.    ||.|..
  Rat   308 KVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPWVRKIFLHKLPKLLCMRSHADR 372

  Fly   525 WL------------------------VRVINSNVLRCILGLRFSDSTDYCDIQENPWHHMAKILN 565
            :.                        :|.|..:|::         ..|..::.|: |..:|::|:
  Rat   373 YFTQREEAESGAGPKSRNTLEAALDCIRYITRHVVK---------ENDVREVVED-WKFIAQVLD 427

  Fly   566 NLSSILVIITFAIVDI 581
            .    :.:.||.:|.|
  Rat   428 R----MFLWTFLLVSI 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	33/198 (17%)
Chrna5	NP_058774.2	LIC	41..448	CDD:273305	70/406 (17%)
		Neur_chan_LBD	47..250	CDD:280998	34/199 (17%)
		Neur_chan_memb	257..446	CDD:280999	34/199 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900