Protein Alignment NtR and Chrna9

DIOPT Version :10

• Sequence 1: NP_651958.2
• Gene: NtR / 43935
• FlyBaseID: FBgn0029147
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_001074573.1
• Gene: Chrna9 / 231252
• MGIID: 1202403
• Length: 479
• Species: Mus musculus
• Alignment Length: 395
• Identity: 83/395 - (21%)
• Similarity: 145/395 - (36%)
• Gaps: 79/395 - (20%)

  Fly   187 GSNTARWFYDCGFDGYGSEIAPIVKEETKTEKLLSHLNIQAENASMPANLSSISFHFQTRSLAYE 251
            |....:.|.|. |:.|.:.:.|:    ..|:.:|        |.::...||.|.        ..:
Mouse    28 GKYAQKLFSDL-FEDYSNALRPV----EDTDAVL--------NVTLQVTLSQIK--------DMD 71

  Fly   252 QTSSLLQTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYEL 316
            :.:.:|...:.:...|.|:.|.|..:.:..|:|...|...:|:|.:.:.|.|.....:.:.:..:
Mouse    72 ERNQILTAYLWIRQTWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVV 136

  Fly   317 MVYANGSITLYAQNLQLASWCVDSARNWPSERVTCDIELG---LNGQEGQENVALIYDDQRKPIA 378
            :.| :|.||..:..:..:| ||.....:|.:...|::..|   .||.:.....||...|....|.
Mouse   137 LRY-DGLITWDSPAITKSS-CVVDVTYFPFDSQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIE 199

  Fly   379 PNEHVNTPSGWSFTQMSVVLVENDSQRRYNPKGMMQKMTGDVAIEFTLQRNRSFYMTVFYLPLIA 443
            ..|       |....|..|       :.....|...:...||.....|:|..|||:....:|.:.
Mouse   200 DVE-------WEVQGMPAV-------KNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVL 250

  Fly   444 CQMFLILSFVL--RSTRRSSL-ILIALLIAAWGLMYMTRYASPHYVPPMMTAYKVIMMTTTYCYI 505
            ......|||.|  .|..:.|| :.|.|.:..:.||          |..:|.|.:.:.:...| ||
Mouse   251 ISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLM----------VAEIMPASENVPLIGKY-YI 304

  Fly   506 LHICIIWLDLYPPRSKAPGWLVRVINSNVLRCILGLRFSDSTDYCDIQENPWHHMAK--ILNNLS 568
            ..:.:|        :.:....:.|:|.:               :|..:..|..|.||  ||..:|
Mouse   305 ATMALI--------TASTALTIMVMNIH---------------FCGAEARPVPHWAKVVILKYMS 346

  Fly   569 SILVI 573
            .||.:
Mouse   347 RILFV 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	89..191	CDD:463505	1/3 (33%)
		Neur_chan_LBD	212..429	CDD:460752	42/219 (19%)
Chrna9	NP_001074573.1	LIC	10..474	CDD:455710	83/395 (21%)
		LGIC_ECD_nAChR_A9	31..237	CDD:349823	48/242 (20%)
		Cys-loop	155..169	CDD:349823	3/13 (23%)