DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and lgc-19

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_502905.2	Gene:	lgc-19 / 190895	WormBaseID:	WBGene00013655	Length:	400	Species:	Caenorhabditis elegans

Alignment Length:	349	Identity:	67/349 - (19%)
Similarity:	120/349 - (34%)	Gaps:	80/349 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 LFVYIPGFKKEPLLQFIDEAPLVINYLSFSSFGSNTARWFYDCGFDGYGSEIAPIVKEETKTEKL 219
            :|:.|..|       |.|....|..|..|.....|..:..    |..|...::|:.   |..:
Worm     9 IFMPIDSF-------FFDPELYVPKYKDFLDVQRNLTKHI----FRDYDPTVSPVY---TWVD-- 57

  Fly   220 LSHLNIQAENASMPANLSSISFHFQTRSLAYEQTSSLLQTRMHMMMHWRDSRLVWKPEDFGSLES 284
             ..|.|..:|.: |...:...|.:..:.:..::....:...|.:|.:|.|:||.|....:.:...
Worm    58 -VDLPIGYDNEA-PKRYNYTIFLYYLKLVEVQEPQEKISVVMEIMEYWYDARLSWNASAWQNTTM 120

  Fly   285 FEHPDLRIWKPHMNVLNG--------------ALQSMGQVLQSYELMVYANGSITLYAQNLQLAS 335
            ......::|.|.::|...              .:::.|.:.....:.|.||
Worm   121 IYMKQDKVWSPTISVFGVNDIVDFRDNDNRLICIENTGFIWDYVSVRVSAN-------------- 171

  Fly   336 WCVDSARNWPSERVTCDIE--LGLNGQEGQENVALIYD---DQR--KPIAPNEHVNTPSGW---S 390
             |......:|.:...|.|.  |.:..:...:.:..||:   |:|  |.:..:|       |   :
Worm   172 -CEMDVSRFPFDTQICQIRFCLPIFYRVQVDILNEIYEEIMDERIFKTMGNSE-------WKLLN 228

  Fly   391 FTQMSVVLVENDSQRRYNPKGMMQKMTGDVAI-EFTLQRNRSFYMTVFYLPLIACQMFLILSFVL 454
            .|.....||.||:.      |.|     |:|| |.|::||..:|:.:...|........|:...|
Worm   229 LTNRVEALVYNDNM------GTM-----DLAIFEITIRRNPLYYIYMIVFPSFIINFVSIVGVFL 282

  Fly   455 RSTRRSSLILIALLIAAWGLMYMT 478
            ....:.|.:.:.|.    .:|.||
Worm   283 NGADKMSRLNVGLT----NIMTMT 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052	9/35 (26%)
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	44/241 (18%)
lgc-19	NP_502905.2	LGIC_ECD_cation	75..257	CDD:349790	39/214 (18%)
		LGIC_TM_cation	259..>346	CDD:349853	9/48 (19%)
		TM1 helix	263..284	CDD:349853	3/20 (15%)
		TM2 helix	292..313	CDD:349853	4/15 (27%)
		TM3 helix	323..346	CDD:349853
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810