DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and lgc-17

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_510028.2	Gene:	lgc-17 / 187976	WormBaseID:	WBGene00011359	Length:	401	Species:	Caenorhabditis elegans

Alignment Length:	422	Identity:	86/422 - (20%)
Similarity:	156/422 - (36%)	Gaps:	110/422 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 LSHLNIQAEN------ASMPANLSSI---SF-----HFQTRS--------LAY-----------E 251
            :.:||.| :|      |:....:||:   ||     |..||:        |.|           |
Worm    30 IDYLNHQ-DNLTRDLFANYDPTISSVYSSSFDYEPSHNHTRTVDRWNYTILLYYLKLVEVQEPEE 93

  Fly   252 QTSSLLQTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVL----Q 312
            :.|.:|:    ::..|.|.||.|....:.::.:......::|.|.::..     .:.:::    |
Worm    94 KVSVVLE----LVEQWYDPRLSWNSSLYSNIPTVFVRQEKVWSPTLSAF-----GVNEIIDFRDQ 149

  Fly   313 SYELMVYAN-GSITLYAQNLQLASWCVDSARNWPSERVTCDIELGL---NGQEGQENVALIYDDQ 373
            .:.::...: |.|..|. :::::|.|......:|.:..||.|...|   |.::     ..|.::.
Worm   150 DFRIVSIDDIGYIQDYL-SVRVSSNCPMDVSRFPFDSQTCQICFCLPIFNIRQ-----VKILNEI 208

  Fly   374 RKPIAPNEHVNT--PSGWSFTQMSVVLVENDSQRRYNPK-GMMQKMTGDVAI-EFTLQRNRSFYM 434
            .:.|...:.:.|  .|.|..    |.|.....|.:|:.. |.|     |:|: |.|::||..:|:
Worm   209 YEGILQEKIIKTMGNSEWKV----VSLTNRVEQLKYDDDYGNM-----DLAVFEITIRRNPLYYI 264

  Fly   435 TVFYLPLIACQMFLILSFVLRSTRRSSLILIALLIAAWGLMYMTRY--ASPHYVP-----PMMTA 492
            .:...|........|:...|:|..:.|.:.:.|.    .:|.||..  .....:|     |::..
Worm   265 YMIVFPSFVINGISIVGIFLKSADKMSKLNVGLT----NIMTMTFILGVMADKIPRTGSIPLLGI 325

  Fly   493 YKVIMMTTTYCYILHICII-----WLDLYPPRSKAPGWLVRVINSNVLRCILGLRFSDSTDYCDI 552
            |.:|.:......|..:.:|     |.   .||.|    |.:...|..|...||
Worm   326 YIIINLLIMIIAITVVVLITELRQWA---VPRLK----LKKSYISRKLETFLG------------ 371

  Fly   553 QENPWHHMAKILNNL---SSILVIITFAIVDI 581
              :|..:...||...   ::..|||.|...|:
Worm   372 --SPIEYTCAILLEFLTTANFFVIIGFWFEDL 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	51/253 (20%)
lgc-17	NP_510028.2	LGIC_ECD_cation	77..259	CDD:349790	39/205 (19%)
		LGIC_TM	261..>317	CDD:365787	11/59 (19%)
		TM1 helix	261..286	CDD:349850	4/24 (17%)
		TM2 helix	294..315	CDD:349850	4/24 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810