Protein Alignment NtR and lgc-16

DIOPT Version :10

• Sequence 1: NP_651958.2
• Gene: NtR / 43935
• FlyBaseID: FBgn0029147
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_510027.2
• Gene: lgc-16 / 187975
• WormBaseID: WBGene00011358
• Length: 401
• Species: Caenorhabditis elegans
• Alignment Length: 475
• Identity: 87/475 - (18%)
• Similarity: 170/475 - (35%)
• Gaps: 108/475 - (22%)

  Fly   136 LVSLYDPTPIEIVQNQNGELFVYIPGFKKEPLLQFIDEAPLVINYLSFSSFGSNTARWFYDCGFD 200
            :|:|:..:.|....:..|   :|.||:               |:||:.....:|..       |.
 Worm     6 IVTLFSFSDISAFYHDPG---LYAPGW---------------IDYLNLQENLTNDL-------FA 45

  Fly   201 GYGSEIAPIVKEETKTEKLLSHLNIQAENASMPANLSSISFH---FQTRSLAYEQTSSLLQTRMH 262
            .|...|:.:..:....|.|       .:|   |..:...::.   :..:.:..::.:..:...:.
 Worm    46 NYDPTISTVYADIADWEPL-------GDN---PRTIDRWNYTILLYYLKLVEVQEPAEKVSVVLE 100

  Fly   263 MMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNV--LNGALQSMGQ--VLQSYELMVYANGS 323
            ::..|.|.||.|....:.::.:......::|.|.::.  :|..:....|  .|.|.:...|.|..
 Worm   101 LVERWYDPRLSWNISLYSNVSTIFARQEKVWSPTLSPFGVNEIIDFRDQDFRLISIDFTGYLNDY 165

  Fly   324 ITLYAQNLQLASWCVDSARNWPSERVTCDIELGL---NGQEGQENVALIYDDQRKPIAPNEHVNT 385
            :     ::::::.|......:|.:..||.|...|   |.::     ..|.::..:.|...:.:.|
 Worm   166 L-----SVRVSANCPMDVSRFPFDSQTCQIRFCLPIFNIRQ-----VKILNEIYEGILQEKIIKT 220

  Fly   386 --PSGWSFTQMSVVLVENDSQRRYNPK-GMMQKMTGDVAI-EFTLQRNRSFYMTVFYLPLIACQM 446
              .|.|..    |.|.....|.:|:.. |.|     |:|: |.|::||..:|:.:...|......
 Worm   221 MGNSEWKV----VSLTNRVEQLKYDDDYGNM-----DLAVFEITIRRNPLYYIYMIVFPSFVING 276

  Fly   447 FLILSFVLRSTRRSSLILIALLIAAWGLMYMTRY--ASPHYVP-----PMMTAYKVIMMTTTYCY 504
            ..|:...|:|..:.|.:.:.|.    .:|.||..  .....:|     |::..|.:|.:......
 Worm   277 ISIVGIFLKSADKMSKLNVGLT----NIMTMTFILGVMADKIPRTGSIPLLGIYIIINLLIMIIA 337

  Fly   505 ILHICII-----WLDLYPPRSKAPGWLVRVINSNVLRCILGLRFSDSTDYCDIQENPWHHMAKIL 564
            |..:.:|     |.   .||.|    |.:...|..|...||              :|..:...||
 Worm   338 ITVVVLITELRQWA---VPRLK----LKKSYMSRKLETFLG--------------SPIEYTCAIL 381

  Fly   565 NNL---SSILVIITFAIVDI 581
            ...   ::..|:|.|...|:
 Worm   382 LEFLTTANFFVMIGFWFEDL 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	89..191	CDD:463505	11/54 (20%)
		Neur_chan_LBD	212..429	CDD:460752	39/230 (17%)
lgc-16	NP_510027.2	LGIC_ECD_cation	77..259	CDD:349790	35/200 (18%)
		Cys-loop	174..188	CDD:349790	2/13 (15%)
		LGIC_TM	261..>317	CDD:476813	11/59 (19%)
		TM1 helix	265..284	CDD:349850	2/18 (11%)
		TM2 helix	291..315	CDD:349850	5/27 (19%)