DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and lgc-15

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_510025.2	Gene:	lgc-15 / 187973	WormBaseID:	WBGene00011356	Length:	399	Species:	Caenorhabditis elegans

Alignment Length:	436	Identity:	78/436 - (17%)
Similarity:	138/436 - (31%)	Gaps:	132/436 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 FDGYGSEIAPIVKEETKTEKLLSHLNIQAENASMPANLSSISFHFQTRSLAYEQTSSLLQTRMHM 263
            |.||.:.|:|:..:...|:.|       ..:...|...:.....|..:.:...:....:...|.:
Worm    43 FSGYDATISPVYTKVDPTQPL-------GHDPDAPGRWNYTLLLFSLKLVEVTEPQEKVSVVMEV 100

  Fly   264 MMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGA--------------LQSMGQVLQSY 314
            |.:|.|:||.|..||:..:.|.......:|.|.::....:              :.|.|.|....
Worm   101 MEYWFDARLTWNKEDYDDIASIYTRQANVWSPTLSAFGVSELVDLRDTDFRLVGITSYGMVNTYV 165

  Fly   315 ELMVYANGSITLYAQNLQLASWCVDSARNWPSERVTCDIELGLNGQEGQENVALIYDDQRKPIAP 379
            .::|.||..:.:|               .:|.:..||.|...:                  |:..
Worm   166 SVLVSANCPMDVY---------------KFPFDYQTCQIRFCI------------------PVFT 197

  Fly   380 NEHVNTPSGWSFTQM-SVVLVENDSQRRYNPKGMMQKMTGDV---------------AIEFTLQR 428
            :..|..     |.:: :.||..|..:...|.:..:..:|..|               ..|..::|
Worm   198 SYEVEI-----FNEIYAGVLTSNAWKTMGNSEWNLVNLTHRVETLKYDDGFANLDLGTFEIKIRR 257

  Fly   429 NRSFYMTVFYLPLIACQMFLILSFVLRSTRRSSLILIALLIAAWGLMYMTRY--ASPHYVP---- 487
            |..:|:.:...|.....:..|:...|:...:.|.:.:.|.    .:|.||..  .....:|
Worm   258 NPLYYIYMIIFPSFIINVVSIIGVFLKGADKMSKLNVGLT----NIMTMTFILGVMADKIPRTGT 318

  Fly   488 -PMMTAYKVIMMTTTYCYILHICIIWLDLYPPRSKAPGWLVRVINSNVLRCILGLRFSDSTDYCD 551
             |::..|.:     |...|:.|.|              .:|.||| .:.||...:.....|
Worm   319 IPLLGVYII-----TNLVIMLIAI--------------GIVTVIN-ELRRCASPVLKRKQT---- 359

  Fly   552 IQENPWHHMAKILNNLSS------------ILVIITFAIVDITSGF 585
                      |:...|.|            ||.::|||...|..||
Worm   360 ----------KLSRKLESFIGTPLEYTCAAILELLTFANFAIMIGF 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	37/246 (15%)
lgc-15	NP_510025.2	LGIC_ECD_cation	74..258	CDD:349790	34/221 (15%)
		LGIC_TM_cation	260..>343	CDD:349853	17/105 (16%)
		TM1 helix	264..285	CDD:349853	3/20 (15%)
		TM2 helix	293..314	CDD:349853	4/24 (17%)
		TM3 helix	324..343	CDD:349853	6/37 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900