Protein Alignment NtR and lgc-14

DIOPT Version :10

• Sequence 1: NP_651958.2
• Gene: NtR / 43935
• FlyBaseID: FBgn0029147
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_510024.2
• Gene: lgc-14 / 187972
• WormBaseID: WBGene00011355
• Length: 400
• Species: Caenorhabditis elegans
• Alignment Length: 437
• Identity: 85/437 - (19%)
• Similarity: 158/437 - (36%)
• Gaps: 94/437 - (21%)

  Fly   177 VINYLSFSSFGSNTARWFYDCGFDGYGSEIAPIVKEETKTEKLLSHLNIQAENASMPANLSSISF 241
            |..|..|....:|..|..    |:||...::|:..:       :..|.....:...|...:....
 Worm    24 VPKYHDFIESQTNLTRDL----FNGYDPTVSPVYSK-------IDPLQPLGYDPDAPKRYNYSIM 77

  Fly   242 HFQTRSLAYEQTSSLLQTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQS 306
            .:..:.:...:.:..:...|.:|.:|.|.||.|....:..:::|......:|.|.::.. ||.:.
 Worm    78 LYSLKLVEVNEPAEKVAVVMEIMEYWYDIRLSWNASLYDDIDTFYTRQSNVWSPTLSAF-GADEL 141

  Fly   307 MGQVLQSYELM-VYANGSITLYAQNLQLASWCVDSARNWPSERVTCDIELGL---NGQE----GQ 363
            :......:.:: |.:||.|..|. :::::|.|..:...:|.:..||.|:..|   |..|    .:
 Worm   142 VDLRDPDFRMVCVNSNGYIYDYI-SVRVSSSCPMNVYKFPFDYQTCQIKFCLPIFNSVEIQIFNE 205

  Fly   364 ENVALIYDDQRKPIAPNEHVNTPSGWSFTQMSVVLVENDSQRRYNPKGMMQKMTG----DVAI-E 423
            ..|.::..|..:.:..:|       |..|.:|            |....:|...|    |:.| |
 Worm   206 IYVGVLMSDLWETMGNSE-------WKLTNLS------------NRVETLQYNDGFGNLDLGIFE 251

  Fly   424 FTLQRNRSFYMTVFYLPLIACQMFLILSFVLRSTRRSSLILIALLIAAWGLMYMTRY--ASPHYV 486
            .|::||..:|:.:...|.....:..|:...|:...:.|.:.:.|.    .:|.||..  .....:
 Worm   252 ITIKRNPLYYIYMIIFPSFIINVVSIIGVFLKGADKMSRLNVGLT----NIMTMTFILGVMADKI 312

  Fly   487 P-----PMMTAYKVIMMTTTYCYILHICIIWLDLYPPRSKAPGWLVRVINSN------VLRCILG 540
            |     ||:..|.::.        |.|.||.:.:....::...||...:..|      .|...:|
 Worm   313 PRTGTIPMLGVYIIVN--------LAIMIIAIGIVTMITELRHWLAPFLKRNETKFSRKLETFIG 369

  Fly   541 --LRFSDSTDYCDIQENPWHHMAKILNNLSSILVIITFAIVDITSGF 585
              |.|:     |.|                 ||.:.|.||..:..||
 Worm   370 PPLEFT-----CAI-----------------ILEVFTCAIFGVMIGF 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	89..191	CDD:463505	4/13 (31%)
		Neur_chan_LBD	212..429	CDD:460752	41/229 (18%)
lgc-14	NP_510024.2	LGIC_ECD_cation	75..257	CDD:349790	39/202 (19%)
		Cys-loop	172..186	CDD:349790	2/13 (15%)
		LGIC_TM	259..349	CDD:476813	17/101 (17%)
		TM1 helix	263..284	CDD:349850	3/20 (15%)
		TM2 helix	292..313	CDD:349850	4/24 (17%)
		TM3 helix	323..345	CDD:349850	5/29 (17%)