DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and lgc-6

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_501410.3	Gene:	lgc-6 / 184621	WormBaseID:	WBGene00017544	Length:	425	Species:	Caenorhabditis elegans

Alignment Length:	403	Identity:	84/403 - (20%)
Similarity:	151/403 - (37%)	Gaps:	77/403 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 EETKTEKLLSHLNIQAENASM-PA-NLSSISFHFQT-RSLAYEQTSSLLQTRMHMMMHWRDSRLV 273
            |.:.||.||..|..|..:..| |: :|:.::....| ..|:.:||...:|.....::.|.|..|.
Worm    15 ETSNTETLLQQLFNQTYDVDMKPSDDLTMVTITPNTFILLSMDQTQETIQYSEEFLLRWYDPILH 79

  Fly   274 WKPEDFGSLESFEHPDLRI-----WKPHMNVLNGALQSMGQVLQSYELM--VYANGSITLYAQNL 331
            |..    |..|:|:..::|     |.|.:...||.  .|..:|.....|  :..||.|.. ::..
Worm    80 WNQ----SAVSYENDWIKISASRAWIPDVIFTNGI--DMDPLLDKDMQMADLRYNGEIRT-SRPA 137

  Fly   332 QLASWCVDSARNWPSERVTCDIELG--------LNGQEGQENVALIYDDQRKPIAPNEHVNTPSG 388
            .::|.|.....|:|.:...|:|.:|        |:.|.....:.    .|:.....|      |.
Worm   138 VVSSPCPLEIDNFPYDVQKCNISMGSWAFDRRFLSVQSSTIEIL----PQKGRFEGN------SE 192

  Fly   389 WSFTQMSVVLVENDSQRRYNPKGMMQKMTGDVAIEFTLQRNRSFYMTVFYLP-LIACQMFLILSF 452
            |..  :|::.|.:||   |:.  ::::...::....||:|...:|:.|...| .|.|.:.:...|
Worm   193 WEL--ISILTVRSDS---YDT--LLEEWFSEITYVVTLKRKPVYYVLVIQAPTFILCTITIFGLF 250

  Fly   453 VLRSTRRSSLILIALLIAAWGLMYMTRYASPHYVP-----PMMTAYKVI-MMTTTYCYILHICI- 510
            ...|.....|..:.|.:..:..:.|........:|     |::..|.:. :...|...|..|.|
Worm   251 TPNSNEDERLSKVELCLNMFAAISMMLQLVSDMMPKASRLPLLGNYIIAEIFVVTAATIASIIIQ 315

  Fly   511 -----IWLDLYPPRSKAPGWLVRVINSNVLRCIL-----GLRFS----DSTDYCDIQENPWHHMA 561
                 :......||.    |         |||::     ..|||    .:....|:.|:.....:
Worm   316 QTHHHVHTSAIRPRR----W---------LRCLVLCECRRRRFSISEASTVSSVDVPEHAIQSFS 367

  Fly   562 KILNNLSSILVII 574
            .:.::|....|::
Worm   368 ILKSSLHQTAVLV 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	53/234 (23%)
lgc-6	NP_501410.3	LIC	1..424	CDD:273305	84/403 (21%)
lgc-6	NP_501410.3	LGIC_ECD_cation	42..226	CDD:349790	43/207 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900