Protein Alignment NtR and lgc-4

DIOPT Version :10

• Sequence 1: NP_651958.2
• Gene: NtR / 43935
• FlyBaseID: FBgn0029147
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_509556.4
• Gene: lgc-4 / 181155
• WormBaseID: WBGene00017580
• Length: 635
• Species: Caenorhabditis elegans
• Alignment Length: 559
• Identity: 108/559 - (19%)
• Similarity: 190/559 - (33%)
• Gaps: 175/559 - (31%)

  Fly    12 YCCL---CLLLILIDPAESGQL---STRFNVSFAQLDSCETYSVPNTGYGYRRFYMLRELSNNNR 70
            |.||   .||.|...|.....:   :|:..|.|:.|||                   |:.::.|
 Worm     5 YSCLTVSILLTIKFVPCRFAGIEHQNTKSRVHFSLLDS-------------------RQENDTN- 49

  Fly    71 KAGERLHLKFYVLTAMDAHILLSVTNHPRPNDRVYEIVIGAGGNTFSAIRNAMGMRRVATNQEPN 135
                              |..::.....:|::.                .|.:|
 Worm    50 ------------------HFEIAEAKFQKPHNE----------------ENTIG----------- 69

  Fly   136 LVSLYDPTPIEIVQNQNGELFVYIPGFKKEPLLQFIDEAPLVINYLSFSSFGSNTARWFYDCGFD 200
            .::.:.|:    ||.|:....:.:|.|.:..|     |..|.|.       ||          .|
 Worm    70 TITKFAPS----VQEQHSSAVIPMPHFDQNRL-----EQALRIK-------GS----------ID 108

  Fly   201 GYGSEIAPIVKEETKTEKLLSHLNIQAE-----NASMPANLSSISFHFQTRSLA-YEQTSSLLQT 259
            |         .||.....||.|...:.:     :.|.|.|   ::|.|....:. .::.:..|.|
 Worm   109 G---------TEEALYRSLLDHTVYEKDVRPCIHHSQPTN---VTFGFLLNQIVEMDERNQALTT 161

  Fly   260 RMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYELMVYANGSI 324
            |..:.::|.|.||.|....:..:::...|..|||||.:.::|.|::.....|.|.::||.::|::
 Worm   162 RSWLNINWMDPRLSWNESLWSEIKAIYIPHARIWKPDIILVNNAIREYYASLVSTDVMVTSDGNV 226

  Fly   325 TLYAQNLQLASWCVDSARNWPSERVTCD------------IELGLNGQEGQENVALIYDDQRKPI 377
            |.....| ..|.|....|.:|.:...||            |.||||..:|.
 Worm   227 TWLFSAL-FRSSCPIRVRYYPFDDQQCDLKFASWSHDITEINLGLNTDKGD-------------- 276

  Fly   378 APNEHVNTPSGWSFTQMS----VVLVENDSQRRYNPKGMMQKMTGDVAIEFTLQRNRSFYMTVFY 438
             .:.::|. |.:....|:    ||...:|:...:          ..:.|...:.|...||:....
 Worm   277 -LSSYMNN-SEFDLVDMTAVREVVTFPSDTNSDW----------PIIVIRIHMHRRPLFYVFNHI 329

  Fly   439 LPLIACQMFLILSFVL--RSTRRSSLILIALLIAAWGLMYMTRYASPHYVPPMMTAYKVIMM--- 498
            :|.:......:|.|::  .:..:.::|:..||.....|..:|     ..:||......:|.|
 Worm   330 VPCVLISSMAVLGFLMPPETGEKINMIITTLLSMGVYLQSIT-----ESIPPTSEGVPLIGMYYV 389

  Fly   499 TTTYCYILHICIIWLDLYPPRSKA-------PGWLVRVI 530
            ::.....|..|:..:.|...|:.|       |.|:.:.|
 Worm   390 SSLLMVCLATCVNVITLNMHRNGAANQGRHVPAWMQKWI 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	89..191	CDD:463505	16/101 (16%)
		Neur_chan_LBD	212..429	CDD:460752	52/238 (22%)
lgc-4	NP_509556.4	LGIC_ECD_nAChR	138..320	CDD:349798	45/211 (21%)
		Cys-loop	238..252	CDD:349798	3/13 (23%)
		LGIC_TM_cation	322..>409	CDD:349853	17/91 (19%)
		TM1 helix	322..346	CDD:349853	5/23 (22%)
		TM2 helix	354..375	CDD:349853	5/25 (20%)
		TM3 helix	386..408	CDD:349853	4/21 (19%)