DRSC/TRiP Functional Genomics Resources

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Protein Alignment NtR and HTR3C

DIOPT Version :10

Sequence 1:NP_651958.2 Gene:NtR / 43935 FlyBaseID:FBgn0029147 Length:585 Species:Drosophila melanogaster
Sequence 2:NP_570126.2 Gene:HTR3C / 170572 HGNCID:24003 Length:447 Species:Homo sapiens


Alignment Length:362 Identity:69/362 - (19%)
Similarity:129/362 - (35%) Gaps:63/362 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   198 GFDGYGSEIAPIVKEETKTEKLLSHLNIQAENASMPANLSSISFHFQTRSLAYEQTSSLLQTRMH 262
            |||.:|  :.|.|.:.....|......    |.|:|..: :|||.. :..|..:....||.:.:.
Human    34 GFDQHG--VDPAVFQAVFDRKAFRPFT----NYSIPTRV-NISFTL-SAILGVDAQLQLLTSFLW 90

  Fly   263 MMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYELMVYANGSITLY 327
            |.:.|.:..:.|.|::...:.........:|.|.:.::..  ..:.|........:.:.|.|. |
Human    91 MDLVWDNPFINWNPKECVGINKLTVLAENLWLPDIFIVES--MDVDQTPSGLTAYISSEGRIK-Y 152

  Fly   328 AQNLQLASWCVDSARNWPSERVTCDIELGLNGQEGQENVALIYDDQRKPIAPNEHVNTPSGWSFT 392
            .:.:::.|.|......:|.::..|.....          :.:|......:..::.|     |..|
Human   153 DKPMRVTSICNLDIFYFPFDQQNCTFTFS----------SFLYTVDSMLLGMDKEV-----WEIT 202

  Fly   393 QMSVVLVENDSQ------RRYNPK-GMMQKMTGDVAIEFTLQRNRSFYMTVFYLPLIACQMFLI- 449
            ..|..:::...:      .:..|| .|...:...:.....::|..|.|:    :.|:....||: 
Human   203 DTSRKVIQTQGEWELLGINKATPKMSMGNNLYDQIMFYVAIRRRPSLYI----INLLVPSSFLVA 263

  Fly   450 ---LSFVL--RSTRRSSLILIALLIAAWGLMYMTRYASPHYVPPMMTAYKVIMM---------TT 500
               |||.|  .|..|:. ..|.||:.....:.|.....|....|:::.|..:.:         |.
Human   264 IDALSFYLPAESENRAP-FKITLLLGYNVFLLMMNDLLPASGTPLISVYFALCLSLMVVSLLETV 327

  Fly   501 TYCYILHICIIWLDLYPPRSKAPGWLVRVINSNVLRC 537
            ...|:||:.    ...||  ..|.||    :|.:|.|
Human   328 FITYLLHVA----TTQPP--PMPRWL----HSLLLHC 354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NtRNP_651958.2 Methyltransf_FA 89..191 CDD:463505
Neur_chan_LBD 212..429 CDD:460752 32/223 (14%)
HTR3CNP_570126.2 LGIC_ECD_5-HT3C_E 31..246 CDD:349814 38/237 (16%)
Cys-loop 162..176 CDD:349814 2/13 (15%)
LGIC_TM_5-HT3 248..446 CDD:349865 30/122 (25%)
TM1 helix 248..272 CDD:349865 8/27 (30%)
TM2 helix 280..301 CDD:349865 4/21 (19%)
TM3 helix 310..332 CDD:349865 2/21 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..405
HA-stretch, determines single-channel conductance in 5-HT3 receptors. /evidence=ECO:0000250|UniProtKB:P46098 401..423
TM4 helix 421..443 CDD:349865
Blue background indicates that the domain is not in the aligned region.

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