DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and HTR3C

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_570126.2	Gene:	HTR3C / 170572	HGNCID:	24003	Length:	447	Species:	Homo sapiens

Alignment Length:	362	Identity:	69/362 - (19%)
Similarity:	129/362 - (35%)	Gaps:	63/362 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 GFDGYGSEIAPIVKEETKTEKLLSHLNIQAENASMPANLSSISFHFQTRSLAYEQTSSLLQTRMH 262
            |||.:|  :.|.|.:.....|......    |.|:|..: :|||.. :..|..:....||.:.:.
Human    34 GFDQHG--VDPAVFQAVFDRKAFRPFT----NYSIPTRV-NISFTL-SAILGVDAQLQLLTSFLW 90

  Fly   263 MMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYELMVYANGSITLY 327
            |.:.|.:..:.|.|::...:.........:|.|.:.::..  ..:.|........:.:.|.|. |
Human    91 MDLVWDNPFINWNPKECVGINKLTVLAENLWLPDIFIVES--MDVDQTPSGLTAYISSEGRIK-Y 152

  Fly   328 AQNLQLASWCVDSARNWPSERVTCDIELGLNGQEGQENVALIYDDQRKPIAPNEHVNTPSGWSFT 392
            .:.:::.|.|......:|.::..|.....          :.:|......:..::.|     |..|
Human   153 DKPMRVTSICNLDIFYFPFDQQNCTFTFS----------SFLYTVDSMLLGMDKEV-----WEIT 202

  Fly   393 QMSVVLVENDSQ------RRYNPK-GMMQKMTGDVAIEFTLQRNRSFYMTVFYLPLIACQMFLI- 449
            ..|..:::...:      .:..|| .|...:...:.....::|..|.|:    :.|:....||:
Human   203 DTSRKVIQTQGEWELLGINKATPKMSMGNNLYDQIMFYVAIRRRPSLYI----INLLVPSSFLVA 263

  Fly   450 ---LSFVL--RSTRRSSLILIALLIAAWGLMYMTRYASPHYVPPMMTAYKVIMM---------TT 500
               |||.|  .|..|:. ..|.||:.....:.|.....|....|:::.|..:.:         |.
Human   264 IDALSFYLPAESENRAP-FKITLLLGYNVFLLMMNDLLPASGTPLISVYFALCLSLMVVSLLETV 327

  Fly   501 TYCYILHICIIWLDLYPPRSKAPGWLVRVINSNVLRC 537
            ...|:||:.    ...||  ..|.||    :|.:|.|
Human   328 FITYLLHVA----TTQPP--PMPRWL----HSLLLHC 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	32/223 (14%)
HTR3C	NP_570126.2	Neur_chan_LBD	43..445	CDD:332142	64/351 (18%)
HTR3C	NP_570126.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..405
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900