Protein Alignment NtR and CHRNE

DIOPT Version :10

• Sequence 1: NP_651958.2
• Gene: NtR / 43935
• FlyBaseID: FBgn0029147
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_000071.1
• Gene: CHRNE / 1145
• HGNCID: 1966
• Length: 493
• Species: Homo sapiens
• Alignment Length: 373
• Identity: 72/373 - (19%)
• Similarity: 145/373 - (38%)
• Gaps: 56/373 - (15%)

  Fly   187 GSNTARWFYDCGFDGYGSEIAPIVK-EETKTEKLLSHLNIQAENASMPANLSSISFHFQTRSLAY 250
            |.|.....|...|:.|.....|:.: |:|.|             .|:...|:::        ::.
Human    20 GKNEELRLYHHLFNNYDPGSRPVREPEDTVT-------------ISLKVTLTNL--------ISL 63

  Fly   251 EQTSSLLQTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYE 315
            .:....|.|.:.:.:.|:|.||.:..:|||.:|:...|...:|.|.: ||...:.....|.....
Human    64 NEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEI-VLENNIDGQFGVAYDAN 127

  Fly   316 LMVYANGSIT-----LYAQNLQLASWCVDSARNWPSERVTCDI---ELGLNGQEGQENVALIYDD 372
            ::||..||:|     :|      .|.|......:|.:...|.:   ....|.:|.:...|:  |:
Human   128 VLVYEGGSVTWLPPAIY------RSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAV--DN 184

  Fly   373 QRKPIAP---NEHVNTPSG-WSFTQMSVVLVENDSQRRYNPKGMMQKMTGDVAIEFTLQRNRSFY 433
            ..|.|..   :....|.:| |:......|:      ||::..........||.....::|...||
Human   185 DGKTINKIDIDTEAYTENGEWAIDFCPGVI------RRHHGGATDGPGETDVIYSLIIRRKPLFY 243

  Fly   434 MTVFYLPLIACQMFLILSFVL--RSTRRSSLILIALLIAAWGLMYMTRYASPH--YVPPMMTAYK 494
            :....:|.:.....::|::.|  ::..:...:.|.:|:|....:::.....|.  ...|::..:.
Human   244 VINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFL 308

  Fly   495 VIMMTTTYCYILHICIIWLDL--YPPRSKAPGWLVRVINSNVLRCILG 540
            :.:|......::: |:|.|::  ..|.:.|....:|.:...:|..:||
Human   309 IFVMVVATLIVMN-CVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLG 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	89..191	CDD:463505	2/3 (67%)
		Neur_chan_LBD	212..429	CDD:460752	45/228 (20%)
CHRNE	NP_000071.1	LGIC_ECD_nAChR_E	49..239	CDD:349831	43/225 (19%)
		Cys-loop	148..162	CDD:349831	2/13 (15%)
		Neur_chan_memb	247..474	CDD:460753	18/110 (16%)