Protein Alignment NtR and Chrne

DIOPT Version :10

• Sequence 1: NP_651958.2
• Gene: NtR / 43935
• FlyBaseID: FBgn0029147
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: XP_006532069.1
• Gene: Chrne / 11448
• MGIID: 87894
• Length: 494
• Species: Mus musculus
• Alignment Length: 379
• Identity: 79/379 - (20%)
• Similarity: 146/379 - (38%)
• Gaps: 64/379 - (16%)

  Fly   185 SFGSNTARWFYDCGFDGYGSEIAPIVK-EETKTEKLLSHLNIQAENASMPANLSSISFHFQTRSL 248
            |.|.|.....|...||.|..|..|:.: |:|.|..|...|          .||.|::
Mouse    18 SQGKNEELSLYHHLFDNYDPECRPVRRPEDTVTITLKVTL----------TNLISLN-------- 64

  Fly   249 AYEQTSSLLQTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQS 313
               :....|.|.:.:.:.|.|.||.:..:||..:.....|...:|.|.: ||...:.....|...
Mouse    65 ---EKEETLTTSVWIGIDWHDYRLNYSKDDFAGVGILRVPSEHVWLPEI-VLENNIDGQFGVAYD 125

  Fly   314 YELMVYANGSIT-----LYAQNLQLASWCVDSARNWPSERVTCDIELGLNGQEGQENVALIY--D 371
            ..::||..|.::     :|      .|.|......:|.:...|.: :..:.....|.|..|:  |
Mouse   126 SNVLVYEGGYVSWLPPAIY------RSTCAVEVTYFPFDWQNCSL-IFRSQTYNAEEVEFIFAVD 183

  Fly   372 DQRKPIAPNEHVNTPSGWSFTQMSVVLVENDSQRRYNPKGMMQKMTG---------DVAIEFTLQ 427
            |....|...: ::|.   :||:.....::      |.| ||:::..|         ||.....::
Mouse   184 DDGNTINKID-IDTA---AFTENGEWAID------YCP-GMIRRYEGGSTEGPGETDVIYTLIIR 237

  Fly   428 RNRSFYMTVFYLPLIACQMFLILSFVL--RSTRRSSLILIALLIAAWGLMYMTRYASPH--YVPP 488
            |...||:....:|.:.....::|::.|  ::..:...:.|.:|:|....:::.....|.  ...|
Mouse   238 RKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVP 302

  Fly   489 MMTAYKVIMMTTTYCYILHICIIWLD--LYPPRSKAPGWLVRVINSNVLRCILG 540
            ::..|.:.:|......::: |:|.|:  |..|.:.|....:|.|...:|..:||
Mouse   303 LLGRYLIFVMVVATLIVMN-CVIVLNVSLRTPTTHATSPRLRQILLELLPRLLG 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	89..191	CDD:463505	3/5 (60%)
		Neur_chan_LBD	212..429	CDD:460752	46/232 (20%)
Chrne	XP_006532069.1	LGIC_ECD_nAChR_E	49..239	CDD:349831	44/229 (19%)
		Cys-loop	148..162	CDD:349831	2/13 (15%)
		Neur_chan_memb	247..475	CDD:460753	21/110 (19%)