Protein Alignment NtR and CHRND

DIOPT Version :10

• Sequence 1: NP_651958.2
• Gene: NtR / 43935
• FlyBaseID: FBgn0029147
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_000742.1
• Gene: CHRND / 1144
• HGNCID: 1965
• Length: 517
• Species: Homo sapiens
• Alignment Length: 327
• Identity: 61/327 - (18%)
• Similarity: 129/327 - (39%)
• Gaps: 40/327 - (12%)

  Fly   201 GYGSEIAPIVKEETKTEKLLSHLNIQAENASMPANLSSISFHFQTRSLAYEQTSSLLQTRMHMMM 265
            ||..|:.|:..:|            ::.:.::...||::        ::.::....|.|.:.:..
Human    37 GYNKELRPVAHKE------------ESVDVALALTLSNL--------ISLKEVEETLTTNVWIEH 81

  Fly   266 HWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYELMVYANGSITLYAQN 330
            .|.|:||.|..|:||::.....|...:|.|.: ||........|:..|..::||..|.: .:...
Human    82 GWTDNRLKWNAEEFGNISVLRLPPDMVWLPEI-VLENNNDGSFQISYSCNVLVYHYGFV-YWLPP 144

  Fly   331 LQLASWCVDSARNWPSERVTCDIELGLNGQEGQENVALIYDDQRKPIAPNEHVNTPSGW------ 389
            ....|.|..|...:|.:...|.::........:|....:..|.:      |:...|..|
Human   145 AIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAK------ENRTYPVEWIIIDPE 203

  Fly   390 SFTQMSV-VLVENDSQRRYNPKGMMQKMT-GDVAIEFTLQRNRSFYMTVFYLPLIACQMFLILSF 452
            .||:... .:|...::...:|:..:...: .|:.....::|...||:....:|.:.....:.|.|
Human   204 GFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVF 268

  Fly   453 VL--RSTRRSSLILIALLI-AAWGLMYMTRYASPHYVPPMMTAYKVIMMTTTYCYILHICIIWLD 514
            .|  .|..::|:.:..||. :.:.|:...|..:.....|::..:.:..|......:: ||:|.|:
Human   269 YLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVV-ICVIVLN 332

  Fly   515 LY 516
            ::
Human   333 IH 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	89..191	CDD:463505
		Neur_chan_LBD	212..429	CDD:460752	38/224 (17%)
CHRND	NP_000742.1	LGIC_ECD_nAChR_D	26..246	CDD:349829	43/236 (18%)
		Cys-loop	151..165	CDD:349829	3/13 (23%)
		Neur_chan_memb	253..489	CDD:460753	16/83 (19%)