DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NtR and Chrna3

DIOPT Version :10

Sequence 1:NP_651958.2 Gene:NtR / 43935 FlyBaseID:FBgn0029147 Length:585 Species:Drosophila melanogaster
Sequence 2:NP_660111.3 Gene:Chrna3 / 110834 MGIID:87887 Length:499 Species:Mus musculus


Alignment Length:382 Identity:76/382 - (19%)
Similarity:143/382 - (37%) Gaps:48/382 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   176 LVINYLSFSSFGSNTARWFYDCGFDGYGSEIAPIVKEETKTEKLLSHLNIQAENASMPANLSSIS 240
            ||:..|..:| .|......:...|:.|...|.|:.                  |.|.|.   .|.
Mouse    15 LVLMLLPVAS-ASEAEHRLFQYLFEDYNEIIRPVA------------------NVSHPV---IIQ 57

  Fly   241 FHFQTRSLA-YEQTSSLLQTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGAL 304
            |......|. .::.:.:::|.:.:...|.|.:|.|||.|:..:|....|..:||||.:.:.|.| 
Mouse    58 FEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNA- 121

  Fly   305 QSMGQVLQSYELMVYANGSITLYAQNLQLASWCVDSARNWPSERVTCDIELGLNGQEGQENVALI 369
            ....||....:.::...|.:|.....: ..|.|......:|.:...|.::.|          :..
Mouse   122 DGDFQVDDKTKALLKYTGEVTWIPPAI-FKSSCKIDVTYFPFDYQNCTMKFG----------SWS 175

  Fly   370 YDDQR-KPIAPNEHVNTPSGWSFTQMSVVLVEN-DSQRRYNPKGMMQKMTGDVAIEFTLQRNRSF 432
            ||..: ..:.....:|....|...:.:::.... ..:.:||   ..:::..|:.....::|...|
Mouse   176 YDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHEIKYN---CCEEIYQDITYSLYIRRLPLF 237

  Fly   433 YMTVFYLPLIACQMFLILSFVLRST--RRSSLILIALLIAAWGLMYMTR-YASPHYVPPMMTAYK 494
            |.....:|.:......:|.|.|.|.  .:.:|.:..||.....|:.:|. ..|...|.|::..|.
Mouse   238 YTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYL 302

  Fly   495 VIMMTTTYCYILHICIIWLDLY---PPRSKAPGWLVRVINSNVLRCILGLRFSDSTD 548
            :..|......|: |.:..|:::   |.....|.| |:.:..|:|..::.:....||:
Mouse   303 LFTMIFVTLSIV-ITVFVLNVHYRTPTTHTMPTW-VKAVFLNLLPRVMFMTRPTSTE 357

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NtRNP_651958.2 Methyltransf_FA 89..191 CDD:463505 5/14 (36%)
Neur_chan_LBD 212..429 CDD:460752 38/219 (17%)
Chrna3NP_660111.3 LIC 24..490 CDD:455710 73/373 (20%)
LGIC_ECD_nAChR_A3 29..235 CDD:349817 43/241 (18%)
Cys-loop 153..167 CDD:349817 2/13 (15%)

Return to query results.
Submit another query.