DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and chrna2

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_004914998.2	Gene:	chrna2 / 100495873	XenbaseID:	XB-GENE-1013893	Length:	510	Species:	Xenopus tropicalis

Alignment Length:	342	Identity:	70/342 - (20%)
Similarity:	135/342 - (39%)	Gaps:	34/342 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 EETKT---EKLLSHLNIQAENASMPANLSS----ISFHFQTRSLA-YEQTSSLLQTRMHMMMHWR 268
            |.|:|   |:|...|.......|.|...:|    :.|......|. .::.:.::.|.:.:...|.
Frog    25 ERTRTHAEERLFKRLFTGYNRWSRPVPNTSDVVIVKFGLSIAQLIDVDEKNQMMTTNVWLKQEWN 89

  Fly   269 DSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYELMVYANGSITLYAQNLQL 333
            |.:|.|.|.|:.::.|...|...||.|.:.:.|.| .....:....:..::.||.:......:..
Frog    90 DYKLRWNPADYDNVTSIRVPSEMIWIPDIVLYNNA-DGEFAITHMTKAHLFHNGKVKWVPPAIYK 153

  Fly   334 ASWCVDSARNWPSERVTCDIELGLNGQEGQENVALIYDDQRKPIAPNE-HVNTPSGWSFTQMSVV 397
            :|..:| ...:|.::.:|.::.|          :..||.....:...| :|:....|...:.::|
Frog   154 SSCSID-VTFFPFDQQSCKMKFG----------SWTYDKAWLDLESMERNVDLKDYWESGEWAIV 207

  Fly   398 LVENDSQRRYNPK--GMMQKMTGDVAIEFTLQRNRSFYMTVFYLPLIACQMFLILSFVLRST--R 458
                ::..:||.|  ....::..|:...|.::|...||.....:|.:......:|.|.|.|.  .
Frog   208 ----NAVGKYNSKKYDCCTEIYPDITYYFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGE 268

  Fly   459 RSSLILIALLIAAWGLMYMTR-YASPHYVPPMMTAYKVIMMTTTYCYILHICIIWLDLY---PPR 519
            :.:|.:..||.....|:.:|. ..|...|.|::..|.:..|......|: |.:..|:::   |..
Frog   269 KITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIV-ITVFVLNVHHRSPST 332

  Fly   520 SKAPGWLVRVINSNVLR 536
            .|.|.|:..|...::.|
Frog   333 HKMPLWVRSVFLDHIPR 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	43/227 (19%)
chrna2	XP_004914998.2	LIC	9..503	CDD:273305	70/342 (20%)
chrna2	XP_004914998.2	LGIC_ECD_nAChR_A2	32..238	CDD:349816	41/221 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910