DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and chrnb1

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001240739.1	Gene:	chrnb1 / 100006941	ZFINID:	ZDB-GENE-070821-4	Length:	492	Species:	Danio rerio

Alignment Length:	368	Identity:	77/368 - (20%)
Similarity:	149/368 - (40%)	Gaps:	51/368 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 CGFDGYGSEIAPIVKEETKTEKLLSHLNIQAENASMP-----ANLSSISFHFQTRSLAYEQTSSL 256
            |...|.|:.......|:...:||.|..|.:...|..|     ..:..|...|.:.::..|:.:::
Zfish    11 CCLCGLGAMTGATEMEDKLMKKLFSAYNSKVRPARNPEERVVVRIGMILSSFVSLNMKDEEMNTI 75

  Fly   257 LQTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYELMVYAN 321
            :.    |.:.|.|.||.|.|:|:|.::.......::|.|.:.::|......|..||.: :..|:|
Zfish    76 VM----MNLEWNDYRLSWNPKDYGGVDVLRISSGKVWLPDIVLINNNDGVFGVALQVH-VQAYSN 135

  Fly   322 GSIT-----LYAQNLQLA------SW--CVDSARNWPSERVTCDIELGLNGQEGQENVALIYDDQ 373
            |.:|     ||..:..:.      .|  |....|::..:....|::..|: :.|:|...:|.|
Zfish   136 GRVTWTPPALYKSSCGVKVTYFPFDWQNCTMVFRSYTYDSSEVDLQHALD-KRGKEIKEIILD-- 197

  Fly   374 RKPIAPNEHVNTPSGWSFTQMSVVLVENDSQRRYNPKGMMQKMTGDVAIEFTLQRNRSFYMTVFY 438
                         :|:|.:.      |...:.:.:.|.:.:.:..|:.....::|...||:....
Zfish   198 -------------TGFSESG------EWHIRHKVSRKNVREDLYEDITFYLIIERKPMFYVVNIV 243

  Fly   439 LPLIACQMFLILSFVL---RSTRRSSLILIALLIAAWGLMYMTRYASPHYVPPMMTAYKVI-MMT 499
            ||.|...:..|.:|.|   ...:....|.:.|.:..:.|:...:........|::..|.:| |:.
Zfish   244 LPCILITIIAIFNFYLPPDAGEKMGLSINVLLTLTVFLLLLANKIPETSLGVPIIVNYLMITMIL 308

  Fly   500 TTYCYILHICIIWLDLYPPRS-KAPGWLVRVINSNVLRCILGL 541
            .|:..||.:.::.|....|.: :.|.| ||.|..::|...||:
Zfish   309 VTFSVILSVVVLNLHHRSPNTHQMPLW-VRKIFIHMLPPYLGM 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	45/234 (19%)
chrnb1	NP_001240739.1	LIC	6..479	CDD:273305	77/368 (21%)
		Neur_chan_LBD	26..235	CDD:280998	46/235 (20%)
		Neur_chan_memb	242..478	CDD:280999	26/110 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810