DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fal and samhd1

DIOPT Version :9

Sequence 1:	NP_001137974.1	Gene:	fal / 43927	FlyBaseID:	FBgn0028380	Length:	368	Species:	Drosophila melanogaster
Sequence 2:	NP_001153405.1	Gene:	samhd1 / 553453	ZFINID:	ZDB-GENE-090313-386	Length:	622	Species:	Danio rerio

Alignment Length:	449	Identity:	106/449 - (23%)
Similarity:	180/449 - (40%)	Gaps:	140/449 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LIEDEVHGVIELSSHIQEIVEHPLFQRLKHVHQLGLLPWAIDKKADHKRYDHCLGAYKSAQDHLR 66
            :..|.:||.|||...:...::.|.||||:|:.||| ..:.:...|.|.|::|.:|....|...::
Zfish    96 VFNDPIHGHIELHPLLLHFIDTPQFQRLRHIKQLG-GTYLVFPGASHNRFEHSIGVGYLAGCLVK 159

  Fly    67 AI-ERNSH-YEPKLPDWCRQAVEIAALLHDIGHGPMSH--------------AW--ELVTHHEFD 113
            |: ||... :..|....|   |:||.|.||:||||.||              .|  |:.:...||
Zfish   160 ALNERQPELFITKQDILC---VQIAGLCHDLGHGPFSHMFDGMFIPKARPADKWKHEIASVQMFD 221

  Fly   114 H--EENAMACVDKIFKDALNQELVSLRDDGGGRGVQLIKALILGSSENLPFPMLGH----TYIFD 172
            |  |.|.:..|.......|.::|:.:::...|.    :::.:|..|:   :|..|.    :::::
Zfish   222 HLVEVNGLEAVMLHHGMRLPEDLIFIKEQIAGP----LESAVLDQSQ---WPYKGRPVEKSFLYE 279

  Fly   173 IVHNRRCGLDVDKWDYLRRDNKRLKILSSAEMDFDDVFLQARI-SPDGQR-IEYRYADYHRVYRL 235
            :|.|:|.|:|||||||..||...|.|.::  .|:......||: ...|:: |..|..:...:|.:
Zfish   280 VVANKRNGIDVDKWDYFARDCYHLGIQNN--FDYQRFLRFARVCEVKGRKHICTRDKEVGNLYDM 342

  Fly   236 FEARSLLHVKAYQ-------------------------------YPLTCAM----------DVIF 259
            |..|:.||.:|||                               :.::.|:          |.||
Zfish   343 FHTRNCLHRRAYQHKVGNIIETMITEAFLKADPHIQIQGSSGRIFTISSAIEDMEAYSKLTDHIF 407

  Fly   260 VSVVQRIAPELLSIRS----------------------------KDPKWLE-------------- 282
            ..::....|||...|:                            |...|.:
Zfish   408 EQILYSSGPELSEARAILQNIICRRLYKCVGQTTSETNVDVSQEKLLDWAKELARSKPTGTEGNL 472

  Fly   283 LTDEYVLNVI-------EKDPISR---YVK-EPHRLVEVPSNDCS-------GSDIIRV 323
            :.:::|::||       ||:||:.   |.| :|.:.:::.....|       ...:|||
Zfish   473 IAEDFVVSVIHMDYGMKEKNPINNVHFYCKNDPTKAIKIHKKQVSKLLPERFAEQLIRV 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fal	NP_001137974.1	HDc	48..210	CDD:238032	53/185 (29%)
samhd1	NP_001153405.1	SAM_HD	22..89	CDD:188907
		SAM	23..86	CDD:197735
		YdhJ	94..>459	CDD:224004	92/375 (25%)
		HDc	139..>242	CDD:214679	32/105 (30%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9Y3Z3	289..295		5/5 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9Y3Z3	350..355		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	571..622
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573540
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1078
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	113	1.000	Inparanoid score	I4827
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D426111at33208
OrthoFinder	1	1.000	-	-		FOG0002596
OrthoInspector	1	1.000	-	-		otm24655
orthoMCL	1	0.900	-	-		OOG6_100615
Panther	1	1.100	-	-	LDO	PTHR11373
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2947
SonicParanoid	1	1.000	-	-		X1701
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.790