Protein Alignment Rok and rock1

DIOPT Version :10

• Sequence 1: NP_536796.2
• Gene: Rok / 43916
• FlyBaseID: FBgn0026181
• Length: 1390
• Species: Drosophila melanogaster
• Sequence 2: XP_002934180.3
• Gene: rock1 / 100496057
• XenbaseID: XB-GENE-984661
• Length: 1360
• Species: Xenopus tropicalis
• Alignment Length: 1414
• Identity: 598/1414 - (42%)
• Similarity: 857/1414 - (60%)
• Gaps: 133/1414 - (9%)

  Fly    21 RANTLEREMRDPTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQLRMNVE 85
            |...::..:|||.|..|.|||||.:.|:|.|.|..::|:.|||:.:..:||....::..|||..:
 Frog    10 RCGRIDGILRDPKSEVNTDCLLDGLDAMVYDLDFPAMRKNKNIDNFLNRYKDTMSKVRDLRMKAD 74

  Fly    86 DFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQL 150
            |:..:|:||.||||||||||||||.:|||||.|||.||:||.|||||||||.|||.|||.|:|||
 Frog    75 DYEVVKVIGRGAFGEVQLVRHKSSRKVYAMKLLSKLEMIKRSDSAFFWEERDIMAFANSPWVVQL 139

  Fly   151 HFAFQDAKYLYMVMDFMPGGDIVSLMGDYDIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNM 215
            .:||||.:||||||::|||||:|:||.:||:|||||.|||.|||||||.||:|||:|||||||||
 Frog   140 FYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNM 204

  Fly   216 LLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLY 280
            |||..||||||||||||:|...|.|....|||||||||||||:|||.|..|||||||||||:|||
 Frog   205 LLDKSGHLKLADFGTCMKMNREGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLY 269

  Fly   281 EMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKA 345
            |||.|:||||||||||||.|||:|||||:||.:.:||::||.||.||||||..||||.|:|:||.
 Frog   270 EMLVGDTPFYADSLVGTYSKIMNHKNSLTFPEDSDISKEAKNLICAFLTDREVRLGRNGVEEIKR 334

  Fly   346 HPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERDEKPEEVFPVPKGFDGNHLPFIGFTY 410
            ||||:||.|:::.:|::|.||||:|:||.||.||:|:|.|:..||.||:||.|.||.|||:||||
 Frog   335 HPFFKNDQWAWETLRDTVAPVVPDLTSDIDTSNFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTY 399

  Fly   411 TGDYQLL-----------SSDTVD---AESKEANVANSGAASNNHGHGHNHRHRPSNSNELKRLE 461
            ..:.|.|           ||.|||   .|:.:.|:                          .:||
 Frog   400 YSNRQYLDDPSANPNDNRSSSTVDKNLVENLQKNI--------------------------YQLE 438

  Fly   462 ALLERERGRSEALEQQDAGLRQQIELITK-------REAELQRIASEYEKDLALRQHNYKVAMQK 519
            ..|..|....:.:||:......:::.|.|       :...|:.:.::.||:..:.||......:|
 Frog   439 EQLHNEMQLKDEMEQKCRMSNIKLDKIMKELDEEGNQRKNLESLVAQTEKEKIMLQHRINEYQRK 503

  Fly   520 VEQEIELRKKTEALLVETQRNLENEQKTRARDLNINDKVVSLEKQLLEMEQSYKTETENTQKLKK 584
            .|||.|.|:..|..:...:..||:.:|........|:|:..|:|||.|.....:||::...:|:|
 Frog   504 AEQESEKRRNVENEVSTLKDQLEDFKKISQTSHITNEKIAQLQKQLEEANDLLRTESDTAVRLRK 568

  Fly   585 HNAELDFTVKSQEEKVRDMVDMIDTLQKHKEELGQENAELQALVVQEKNLRSQLKEMHKEAENKM 649
            ...|:..||...|...|::.|....|:..|.::.::...|||.:..|:..|||..||..:.:.:|
 Frog   569 SQTEMSKTVSQLEALNRELQDRCRLLESSKSQVEKDYFHLQAALDSERRDRSQGSEMIGDLQARM 633

  Fly   650 QTLINDIERTMCREQKAQEDNRALLEKISDLEK----AHAGLDFELKAAQGRYQQEVKAHQETEK 710
            .:|..:::......:.|:.:.:...:.:::.||    ....|:::||..|...:||:..|:.| |
 Frog   634 ASLQEELKHVKNNLEMAESERKRAQDLLNNSEKEKNNLEIDLNYQLKTLQQMLEQEINEHKVT-K 697

  Fly   711 SRLVSREEANLQEVKA-----LQSKLNEEKSARIKADQHSQEKERQLSMLSVDYRQIQLRLQKLE 770
            :||..|.: :.:|.|:     ::.|:..|::|:.||:....|.|:|.|||..|.:|.:.:::...
 Frog   698 ARLSDRHQ-SFEEEKSVAMCEMEMKVKGERAAKEKAENRRVEIEKQCSMLEFDLKQSRQKMEHFT 761

  Fly   771 GECRQESEKVAALQSQLDQEHSKRNALLSELSLHSSEVAHLRSRENQLQKELSTQREAKRRFEED 835
            .:..:..|:|..|..||:.|..||....:||:.|:..|..|:..|.||::|::|..||||..|.:
 Frog   762 QQRERLEEEVKQLTLQLEHETKKRIVTQNELNQHAGLVDTLKGSEKQLKQEINTLLEAKRLLEFE 826

  Fly   836 LTQLKSTHHEALANNRELQAQLEAEQCFSRLYKTQANENREESAERL-------SKIEDLEEERV 893
            |.||...:.......||||.||||||.||.|||||..|.:||..|:.       .::.:|..::.
 Frog   827 LGQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVRELKEEVEEKTKHSHELEKRVHELYNDKD 891

  Fly   894 SLKHQVQVAVARADSEALARSIAEETVADL----------------EKEKTIKELELKDFVMKHR 942
            :|..|:.:|..:|:||.|||::.||...::                ||:.||::||       ..
 Frog   892 TLTAQLDLAETKAESEQLARTLLEEQYFEVNQENKKLSARSWQDNTEKDHTIRKLE-------ET 949

  Fly   943 NEINAKEAALATLKEAENELHKKLGQKAAEYEDLVQQHKKQQEELALMRSSKDEEITKLLDKCKN 1007
            |....|:  :.||.:|..|    |.:||.:.|   |::|:::||:..:|:|.::.|       ..
 Frog   950 NSTLTKD--VQTLTKANEE----LSEKARKLE---QEYKEKEEEIYNLRNSYEKAI-------NT 998

  Fly  1008 EVLLKQVAVNKLAEVMNRRDSDLPKQKNKARSTAELRKKEKEMRRLQQELSQERDKFNQLLLKHQ 1072
            |..||..|||||||:|||:|..|.::|   .:|.:|||||||.|:||.:|:||::|:||::.|:|
 Frog   999 EKTLKTQAVNKLAEIMNRKDFKLDRKK---ANTQDLRKKEKENRKLQLDLNQEKEKYNQMVAKYQ 1060

  Fly  1073 -----DLQQLCAEEQQLKQKMVMEIDCKATEIENLQSKLNETA----SLSSADNDPEDSQHSSLL 1128
                 .|.|| .||...|.::.|::|.|.::||.|:::|.:..    |.|.|...|:|:.
 Frog  1061 KELDETLMQL-TEESNYKNELQMQLDSKESDIEQLRARLADLQLRMDSTSVASLQPDDTD----- 1119

  Fly  1129 SLTQDSVFEGWLSVPNKQNRRRGHGWKRQYVIVSSRKIIFYNSDIDKHNTTDAVLILDLSKVYHV 1193
            .:..:|..|||||:||:.|.:| :|||:|||:|||:||:|||.:.:|..::.: ::||:.|::||
 Frog  1120 GIIGESRIEGWLSIPNRGNIKR-YGWKKQYVVVSSKKILFYNDEQNKEQSSPS-MVLDIDKLFHV 1182

  Fly  1194 RSVTQGDVIRADAKEIPRIFQLLYAGEGASHRPDEQSQLDVSVLHGNCNEERPGTIVHKGHEFVH 1258
            |:||||||.||:.:|||||||:|||.||...:..|...:.        ..|:...:.||||||:.
 Frog  1183 RAVTQGDVYRANTEEIPRIFQILYANEGECRKDVELEPVQ--------QTEKTNFLNHKGHEFIP 1239

  Fly  1259 ITYHMPTACEVCPKPLWHMFKPPAAYECKRCRNKIHKEHVDKHDPL-APCKLNHDPRSARDMLLL 1322
            ..||.|..||.|.|||||:||||.|.||:||..|.||:|:||.:.| :|||:::|..||||||||
 Frog  1240 TLYHFPANCEACAKPLWHVFKPPPALECRRCHVKCHKDHLDKKEELISPCKVSYDVTSARDMLLL 1304

  Fly  1323 AATPEDQSLWVARLLKRIQKSGYKAASYNNNSTDGSKISPSQSTRSSYK 1371
            |.|.|:|:.||:.|:|:|.|:........|..|..::.|.:||.|...|
 Frog  1305 ACTQEEQTKWVSHLVKKIPKTPPPTLVRGNQRTMSTRSSTNQSFRKPAK 1353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	239/349 (68%)
		Smc	527..>1121	CDD:440809	199/634 (31%)
		ROCK_SBD	849..920	CDD:409019	33/77 (43%)
		PH_ROCK	1134..1250	CDD:269948	53/115 (46%)
		C1_ROCK	1247..1310	CDD:410363	36/63 (57%)
rock1	XP_002934180.3	STKc_ROCK1	2..406	CDD:270772	257/395 (65%)
		SMC_prok_B	<414..1107	CDD:274008	220/747 (29%)
		HR1_ROCK1	491..556	CDD:212029	19/64 (30%)
		ROCK_SBD	838..918	CDD:409019	33/79 (42%)
		PH_ROCK	1125..1231	CDD:269948	53/115 (46%)
		C1_ROCK1	1228..1296	CDD:410424	37/67 (55%)