DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rok and rock1

DIOPT Version :9

Sequence 1:	NP_536796.2	Gene:	Rok / 43916	FlyBaseID:	FBgn0026181	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	XP_002934180.3	Gene:	rock1 / 100496057	XenbaseID:	XB-GENE-984661	Length:	1360	Species:	Xenopus tropicalis

Alignment Length:	1414	Identity:	598/1414 - (42%)
Similarity:	857/1414 - (60%)	Gaps:	133/1414 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RANTLEREMRDPTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQLRMNVE 85
            |...::..:|||.|..|.|||||.:.|:|.|.|..::|:.|||:.:..:||....::..|||..:
Frog    10 RCGRIDGILRDPKSEVNTDCLLDGLDAMVYDLDFPAMRKNKNIDNFLNRYKDTMSKVRDLRMKAD 74

  Fly    86 DFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQL 150
            |:..:|:||.||||||||||||||.:|||||.|||.||:||.|||||||||.|||.|||.|:|||
Frog    75 DYEVVKVIGRGAFGEVQLVRHKSSRKVYAMKLLSKLEMIKRSDSAFFWEERDIMAFANSPWVVQL 139

  Fly   151 HFAFQDAKYLYMVMDFMPGGDIVSLMGDYDIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNM 215
            .:||||.:||||||::|||||:|:||.:||:|||||.|||.|||||||.||:|||:|||||||||
Frog   140 FYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNM 204

  Fly   216 LLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLY 280
            |||..||||||||||||:|...|.|....|||||||||||||:|||.|..|||||||||||:|||
Frog   205 LLDKSGHLKLADFGTCMKMNREGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLY 269

  Fly   281 EMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKA 345
            |||.|:||||||||||||.|||:|||||:||.:.:||::||.||.||||||..||||.|:|:||.
Frog   270 EMLVGDTPFYADSLVGTYSKIMNHKNSLTFPEDSDISKEAKNLICAFLTDREVRLGRNGVEEIKR 334

  Fly   346 HPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERDEKPEEVFPVPKGFDGNHLPFIGFTY 410
            ||||:||.|:::.:|::|.||||:|:||.||.||:|:|.|:..||.||:||.|.||.|||:||||
Frog   335 HPFFKNDQWAWETLRDTVAPVVPDLTSDIDTSNFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTY 399

  Fly   411 TGDYQLL-----------SSDTVD---AESKEANVANSGAASNNHGHGHNHRHRPSNSNELKRLE 461
            ..:.|.|           ||.|||   .|:.:.|:                          .:||
Frog   400 YSNRQYLDDPSANPNDNRSSSTVDKNLVENLQKNI--------------------------YQLE 438

  Fly   462 ALLERERGRSEALEQQDAGLRQQIELITK-------REAELQRIASEYEKDLALRQHNYKVAMQK 519
            ..|..|....:.:||:......:::.|.|       :...|:.:.::.||:..:.||......:|
Frog   439 EQLHNEMQLKDEMEQKCRMSNIKLDKIMKELDEEGNQRKNLESLVAQTEKEKIMLQHRINEYQRK 503

  Fly   520 VEQEIELRKKTEALLVETQRNLENEQKTRARDLNINDKVVSLEKQLLEMEQSYKTETENTQKLKK 584
            .|||.|.|:..|..:...:..||:.:|........|:|:..|:|||.|.....:||::...:|:|
Frog   504 AEQESEKRRNVENEVSTLKDQLEDFKKISQTSHITNEKIAQLQKQLEEANDLLRTESDTAVRLRK 568

  Fly   585 HNAELDFTVKSQEEKVRDMVDMIDTLQKHKEELGQENAELQALVVQEKNLRSQLKEMHKEAENKM 649
            ...|:..||...|...|::.|....|:..|.::.::...|||.:..|:..|||..||..:.:.:|
Frog   569 SQTEMSKTVSQLEALNRELQDRCRLLESSKSQVEKDYFHLQAALDSERRDRSQGSEMIGDLQARM 633

  Fly   650 QTLINDIERTMCREQKAQEDNRALLEKISDLEK----AHAGLDFELKAAQGRYQQEVKAHQETEK 710
            .:|..:::......:.|:.:.:...:.:::.||    ....|:::||..|...:||:..|:.| |
Frog   634 ASLQEELKHVKNNLEMAESERKRAQDLLNNSEKEKNNLEIDLNYQLKTLQQMLEQEINEHKVT-K 697

  Fly   711 SRLVSREEANLQEVKA-----LQSKLNEEKSARIKADQHSQEKERQLSMLSVDYRQIQLRLQKLE 770
            :||..|.: :.:|.|:     ::.|:..|::|:.||:....|.|:|.|||..|.:|.:.:::...
Frog   698 ARLSDRHQ-SFEEEKSVAMCEMEMKVKGERAAKEKAENRRVEIEKQCSMLEFDLKQSRQKMEHFT 761

  Fly   771 GECRQESEKVAALQSQLDQEHSKRNALLSELSLHSSEVAHLRSRENQLQKELSTQREAKRRFEED 835
            .:..:..|:|..|..||:.|..||....:||:.|:..|..|:..|.||::|::|..||||..|.:
Frog   762 QQRERLEEEVKQLTLQLEHETKKRIVTQNELNQHAGLVDTLKGSEKQLKQEINTLLEAKRLLEFE 826

  Fly   836 LTQLKSTHHEALANNRELQAQLEAEQCFSRLYKTQANENREESAERL-------SKIEDLEEERV 893
            |.||...:.......||||.||||||.||.|||||..|.:||..|:.       .::.:|..::.
Frog   827 LGQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVRELKEEVEEKTKHSHELEKRVHELYNDKD 891

  Fly   894 SLKHQVQVAVARADSEALARSIAEETVADL----------------EKEKTIKELELKDFVMKHR 942
            :|..|:.:|..:|:||.|||::.||...::                ||:.||::||       ..
Frog   892 TLTAQLDLAETKAESEQLARTLLEEQYFEVNQENKKLSARSWQDNTEKDHTIRKLE-------ET 949

  Fly   943 NEINAKEAALATLKEAENELHKKLGQKAAEYEDLVQQHKKQQEELALMRSSKDEEITKLLDKCKN 1007
            |....|:  :.||.:|..|    |.:||.:.|   |::|:::||:..:|:|.::.|       ..
Frog   950 NSTLTKD--VQTLTKANEE----LSEKARKLE---QEYKEKEEEIYNLRNSYEKAI-------NT 998

  Fly  1008 EVLLKQVAVNKLAEVMNRRDSDLPKQKNKARSTAELRKKEKEMRRLQQELSQERDKFNQLLLKHQ 1072
            |..||..|||||||:|||:|..|.::|   .:|.:|||||||.|:||.:|:||::|:||::.|:|
Frog   999 EKTLKTQAVNKLAEIMNRKDFKLDRKK---ANTQDLRKKEKENRKLQLDLNQEKEKYNQMVAKYQ 1060

  Fly  1073 -----DLQQLCAEEQQLKQKMVMEIDCKATEIENLQSKLNETA----SLSSADNDPEDSQHSSLL 1128
                 .|.|| .||...|.::.|::|.|.::||.|:::|.:..    |.|.|...|:|:.
Frog  1061 KELDETLMQL-TEESNYKNELQMQLDSKESDIEQLRARLADLQLRMDSTSVASLQPDDTD----- 1119

  Fly  1129 SLTQDSVFEGWLSVPNKQNRRRGHGWKRQYVIVSSRKIIFYNSDIDKHNTTDAVLILDLSKVYHV 1193
            .:..:|..|||||:||:.|.:| :|||:|||:|||:||:|||.:.:|..::.: ::||:.|::||
Frog  1120 GIIGESRIEGWLSIPNRGNIKR-YGWKKQYVVVSSKKILFYNDEQNKEQSSPS-MVLDIDKLFHV 1182

  Fly  1194 RSVTQGDVIRADAKEIPRIFQLLYAGEGASHRPDEQSQLDVSVLHGNCNEERPGTIVHKGHEFVH 1258
            |:||||||.||:.:|||||||:|||.||...:..|...:.        ..|:...:.||||||:.
Frog  1183 RAVTQGDVYRANTEEIPRIFQILYANEGECRKDVELEPVQ--------QTEKTNFLNHKGHEFIP 1239

  Fly  1259 ITYHMPTACEVCPKPLWHMFKPPAAYECKRCRNKIHKEHVDKHDPL-APCKLNHDPRSARDMLLL 1322
            ..||.|..||.|.|||||:||||.|.||:||..|.||:|:||.:.| :|||:::|..||||||||
Frog  1240 TLYHFPANCEACAKPLWHVFKPPPALECRRCHVKCHKDHLDKKEELISPCKVSYDVTSARDMLLL 1304

  Fly  1323 AATPEDQSLWVARLLKRIQKSGYKAASYNNNSTDGSKISPSQSTRSSYK 1371
            |.|.|:|:.||:.|:|:|.|:........|..|..::.|.:||.|...|
Frog  1305 ACTQEEQTKWVSHLVKKIPKTPPPTLVRGNQRTMSTRSSTNQSFRKPAK 1353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	239/349 (68%)
		S_TKc	87..349	CDD:214567	194/261 (74%)
		SbcC	484..1088	CDD:223496	200/647 (31%)
		Rho_Binding	963..1027	CDD:286056	24/63 (38%)
		PH_ROCK	1134..1250	CDD:269948	53/115 (46%)
		C1	1254..1307	CDD:197519	30/53 (57%)
rock1	XP_002934180.3	STKc_ROCK1	2..406	CDD:270772	257/395 (65%)
		Smc	<424..1107	CDD:224117	215/737 (29%)
		HR1_ROCK1	491..556	CDD:212029	19/64 (30%)
		ROCK_SBD	838..918	CDD:409019	33/79 (42%)
		PH_ROCK	1125..1231	CDD:269948	53/115 (46%)
		C1_ROCK1	1228..1296	CDD:410424	37/67 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	416	1.000	Domainoid score	I653
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1059	1.000	Inparanoid score	I254
OMA	1	1.010	-	-		QHG46537
OrthoDB	1	1.010	-	-		D36370at33208
OrthoFinder	1	1.000	-	-		FOG0001986
OrthoInspector	1	1.000	-	-		otm49226
Panther	1	1.100	-	-	LDO	PTHR22988
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1475
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080