Protein Alignment Ret and Lyn

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_110484.1
• Gene: Lyn / 81515
• RGDID: 621017
• Length: 512
• Species: Rattus norvegicus
• Alignment Length: 277
• Identity: 107/277 - (38%)
• Similarity: 157/277 - (56%)
• Gaps: 21/277 - (7%)

  Fly   764 WEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQE 828
            ||.|||.::|...||.|:||:|..|:..      ..|.||||.||.|:.|.:  |.|.|..|::.
  Rat   240 WEIPRESIKLVKKLGAGQFGEVWMGYYN------NSTKVAVKTLKPGTMSAQ--AFLEEANLMKT 296

  Fly   829 VSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAW 893
            :.|..:::|....|..|...:|.|:...|||..:|:            :|....|.:..::.|:.
  Rat   297 LQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLK------------SDEGSKVLLPKLIDFSA 349

  Fly   894 QICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPE 958
            ||.:||||:.....:||||.|.|||:::..:|||:||||.| |.||:.|..|...:.|:||.|||
  Rat   350 QIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLAR-VIEDNEYTAREGAKFPIKWTAPE 413

  Fly   959 SLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRT 1023
            ::....:|.||||||||:|.:|::|.|..||||....::.:.|..||||.|.|||.:.:|.|::.
  Rat   414 AINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRMENCPDELYDIMKM 478

  Fly  1024 CWADEPNGRPSFKFLAS 1040
            ||.:....||:|.:|.|
  Rat   479 CWKESAEERPTFDYLQS 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	102/271 (38%)
Lyn	NP_110484.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50
		SH3_Lyn	67..122	CDD:212937
		SH2_Src_Lyn	125..225	CDD:198227
		PTKc_Lyn	239..510	CDD:270657	107/277 (39%)