Protein Alignment Ret and BTK

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001274273.1
• Gene: BTK / 695
• HGNCID: 1133
• Length: 693
• Species: Homo sapiens
• Alignment Length: 281
• Identity: 100/281 - (35%)
• Similarity: 143/281 - (50%)
• Gaps: 22/281 - (7%)

  Fly   760 GDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQ 824
            |...||...:.|.....||.|:||.|..|      ...|...||:||:|:||.|.:  ..:.|.:
Human   425 GYGSWEIDPKDLTFLKELGTGQFGVVKYG------KWRGQYDVAIKMIKEGSMSED--EFIEEAK 481

  Fly   825 LLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVL 889
            ::..:||..:::|.|.||......:|.||...|.|.:|||..|             .....:.:|
Human   482 VMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMR-------------HRFQTQQLL 533

  Fly   890 TFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKW 954
            .....:|:.|.||...:.:||||||||.|:.|..:.|:|||||:|.|. ||.|......:.||:|
Human   534 EMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVL-DDEYTSSVGSKFPVRW 597

  Fly   955 MAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYS 1019
            ..||.|....::||||:|:||||.||:.:||..||...........:..|.|:.||...||.||:
Human   598 SPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYT 662

  Fly  1020 IVRTCWADEPNGRPSFKFLAS 1040
            |:.:||.::.:.||:||.|.|
Human   663 IMYSCWHEKADERPTFKILLS 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	97/271 (36%)
BTK	NP_001274273.1	PH_Btk	40..200	CDD:269944
		SH3_BTK	251..305	CDD:212839
		SH2_Tec_Btk	308..413	CDD:198260
		PTKc_Btk_Bmx	431..686	CDD:173657	97/275 (35%)