Protein Alignment Ret and ntrk3a

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001243593.1
• Gene: ntrk3a / 568668
• ZFINID: ZDB-GENE-010126-3
• Length: 818
• Species: Danio rerio
• Alignment Length: 806
• Identity: 191/806 - (23%)
• Similarity: 285/806 - (35%)
• Gaps: 259/806 - (32%)

  Fly   426 DKDVSVYRS------AASNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQV 484
            |.|:.:|..      ...|.|.:|..:|.....||.|       .|....:|:.|..:| :|.|:
Zfish    94 DLDMELYTGLQRLNIVNCNLRTIQSRAFAKNPHLRYI-------NLSRNPLTTLSWQLF-QNLQL 150

  Fly   485 LEEAPETIYF---LNVTWID--QQRLSHVRVINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQ 544
            ||...|.:.|   .|:.||.  ||| ....:.|..|.        |   ....|:...|:...||
Zfish   151 LELKLEGVVFNCSCNIRWIQLWQQR-GEAGLHNQQLF--------C---FNGYSKIPLQLMNISQ 203

  Fly   545 C------VRYCGLATGGG-----SCQWRGSNSAMFGTRYGSCVPESRYCPDHVCDPLEELNPMAC 598
            |      |.:..|....|     :|  .||         |..|||
Zfish   204 CDFPEISVSHSNLTVTEGDRVMITC--NGS---------GIPVPE-------------------- 237

  Fly   599 PQDCTPAG-RIVGPHSSNENKRGIYSA-----------SG---TCICEDNGKCSCAPLD------ 642
             .|.|..| ..:..|.:|:....::|.           :|   |||.|:....:.|.:.
Zfish   238 -VDWTVGGLHSINTHQANQYPPNVHSINLTLVNVSRDDNGFMLTCIAENIVGMTNASIQLSVQFP 301

  Fly   643 ------EEPK--------------------------------------------------MKKPR 651
                  |||:                                                  .|.|.
Zfish   302 PAIINFEEPQKRHDTCMMFTVRANPLPTLHWSFKGEEIKATEYVHPEMEVYQDNLEGCLLFKNPT 366

  Fly   652 KRKN---ETEAEPLLGVRRGT-------PP-------------------NQPLQDPMLLGV-LNV 686
            :..|   ..||...|||...|       ||                   ::|.:|...:.: :.:
Zfish   367 QHNNGNYTLEARNYLGVAVKTVYAHFLHPPFEDYPDYVSPTPTAIPTMTHRPEEDTFGVSIAVGL 431

  Fly   687 AGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQ------SMTTSSKQALPESGGGD 745
            |||.|               |||::..::..:...:.:.|.:      |....|...|.....|.
Zfish   432 AGFAC---------------VLLVVMFVLINKYGRRSKFGMKGPVAVISGEEDSASPLHHVNHGI 481

  Fly   746 FALMPLQSG-------------------FRFESGDAK-----WEFPREKLQLDTVLGEGEFGQVL 786
            .....|.:|                   ||......|     ....|..:.|...||||.||:|.
Zfish   482 ITPCTLDAGPDAVVIGMTRIPVIENPQYFRHGHNCNKPATYVQHIKRRDIVLKRELGEGAFGKVF 546

  Fly   787 KGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQ----LLQEVSHPNVIKLLGACTSSEAP 847
            ......::.......||||.||..:     :|...:||    ||..:.|.:::|..|.|...:..
Zfish   547 LAECYNLSPTKDKMLVAVKTLKDPT-----LAARKDFQREAELLTNLQHEHIVKFYGVCVDGDPL 606

  Fly   848 LLIIEYARYGSLRSYLRLSRKIECAGVD---FADGVEP------VNVKMVLTFAWQICKGMAYLS 903
            :::.||.::|.|..:||      ..|.|   ..|| :|      :.:..:|..|.||..||.||.
Zfish   607 IMVFEYMKHGDLNKFLR------AHGPDAMILVDG-QPLQTNGELGLSQMLHIASQIASGMVYLG 664

  Fly   904 ELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSK 968
            ....||||||.||.|:.:|.:.||.|||::||:|..|.|.......:|::||.|||:....:|::
Zfish   665 SQHFVHRDLATRNCLVGNGLLVKIGDFGMSRDIYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTE 729

  Fly   969 SDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRP 1033
            ||||||||:.||:.|.|..|:..:|...:...:..|..::||..|.:.||.|:..||..||..|.
Zfish   730 SDVWSFGVILWEIFTYGKQPWFQLANNEVIECITQGRVLERPRLCPKEVYDIMLGCWQREPQQRL 794

  Fly  1034 SFKFLASEFEKLLGNNAK----YIDL 1055
            :.|    :.:|:|....|    |:|:
Zfish   795 NIK----DIQKILFALGKATPVYLDI 816

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	98/291 (34%)
ntrk3a	NP_001243593.1	LRR	<46..>153	CDD:443914	17/66 (26%)
		LRR_8	101..157	CDD:404697	15/63 (24%)
		leucine-rich repeat	103..126	CDD:275378	4/22 (18%)
		leucine-rich repeat	127..150	CDD:275378	8/30 (27%)
		LRRCT_2	161..205	CDD:465313	13/55 (24%)
		Ig_3	207..285	CDD:464046	20/109 (18%)
		Ig	301..393	CDD:472250	12/91 (13%)
		Ig strand B	316..320	CDD:409353	0/3 (0%)
		Ig strand C	329..333	CDD:409353	0/3 (0%)
		Ig strand E	358..362	CDD:409353	0/3 (0%)
		Ig strand F	372..377	CDD:409353	0/4 (0%)
		Ig strand G	385..388	CDD:409353	0/2 (0%)
		PTKc_TrkC	525..811	CDD:270676	100/301 (33%)